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Head & Face Medicine

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Open Access 01-12-2013 | Research

Current state of orthodontic patients under Bisphosphonate therapy

Authors: Elena Krieger, Collin Jacobs, Christian Walter, Heinrich Wehrbein

Published in: Head & Face Medicine | Issue 1/2013

Abstract

Background

Bisphosphonates are a common medication for the prevention and therapy of osteoporosis, but are also applied for tumor diseases. They affect bone metabolism, and therefore also orthodontic treatments, but how it does has yet not been definitively clarified. Therefore, the aim of this research was to evaluate and demonstrate the reported effects and the current state of scientific research regarding orthodontic treatment and bisphosphonate medication exclusively in humans.

Material and methods

A systematic research of the literature for selected keywords in the Medline database (Pubmed) as well as a manual search was conducted. The following search terms were used: ‘Bisphosphonate’ in combination with: orthodontic, orthodontic treatment, tooth movement.

Findings

To date, only nine reported patients (case reports/series) and one original article (retrospective cohort study) regarding orthodontic treatment under bisphosphonate medication in humans have been published. Decelerated tooth movement with increased side effects (especially in high-risk patients) and longer treatment duration was reported in some articles. Patients with initial spacing or extraction cases had a higher risk of incomplete space closure and poor root parallelism.

Conclusions

Orthodontic tooth movement under bisphosphonate medication is possible, especially in low-risk patients (low dose and short period of intake). But the treatment is still not predictable, especially in high-risk patients. Therefore, the altered bone metabolism and higher extent of side effects should be considered in treatment planning, especially in extraction cases or high-risk patients. Regardless, longer treatment duration, decelerated tooth movement, and more side effects, e.g., incomplete space closure and poor root parallelism, should be expected, especially in extraction cases or space closure.

Zahrowski JJ: Bisphosphonate treatment: an orthodontic concern calling for a proactive approach. Am J Orthod Dentofacial Orthop. 2007, 131: 311-20. 10.1016/j.ajodo.2006.09.035.CrossRefPubMed

Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, Koutsoukou V, Gika D, Anagnostopoulos A, Papadimitriou C, Terpos E, Dimopoulos MA: Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol. 2005, 23: 8580-7. 10.1200/JCO.2005.02.8670.CrossRefPubMed

Abu-Id MH, Açil Y, Gottschalk J, Kreusch T: Bisphosphonate-associated osteonecrosis of the jaw [Article in German]. Mund Kiefer Gesichtschir. 2006, 10: 73-81. 10.1007/s10006-005-0670-0.CrossRefPubMed

American Dental Association Council of Scientific Affairs: Dental management of patients receiving oral bisphosphonate therapy. J Am Dent Assoc. 2006, 137: 1144-50.CrossRef

Grötz KA, Kreusch T: Zahnärztliche Betreuung von Patienten unter/nach Bisphosphonat-Medikation. Wissenschaftliche Stellungnahme der DGZMK. 2006, Version 1.0. DZZ 60 (10); http://www.dgzmk.de/uploads/tx_szdgzmkdocuments/Zahnaerztliche_Betreuung_von_Patienten_unternach_Bisphosphonat-Medikation.pdf

Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B: American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws—2009 Update. J Oral Maxillofac Surg. 2009, 67: 2-12.CrossRefPubMed

Ruggiero SL: Bisphosphonate-related osteonecrosis of the jaw: an overview. Ann N Y Acad Sci. 2011, 1218: 38-46. 10.1111/j.1749-6632.2010.05768.x.CrossRefPubMed

Walter C, Al-Nawas B, Frickhofen N, Gamm H, Beck J, Reinsch L, Blum C, Grötz KA, Wagner W: Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients. Head Face Med. 2010, 8 (6): 11-CrossRef

Vitral RW, da Silva Campos MJ, de Andrade Vitral JC, Santiago RC, Fraga MR: Orthodontic distalization with rigid plate fixation for anchorage after bone grafting and maxillary sinus lifting. Am J Orthod Dentofacial Orthop. 2009, 136: 109-14. 10.1016/j.ajodo.2007.07.024.CrossRefPubMed

10.

Kodama Y, Ogose A, Oguri Y, Ubaidus S, Iizuka T, Takagi R: Alveolar bone grafting in association with polyostotic fibrous dysplasia and bisphosphonate-induced abnormal bone turnover in a bilateral cleft lip and palate patient: a case report. J Oral Maxillofac Surg. 2012, 70: e500-8. 10.1016/j.joms.2012.05.015.CrossRefPubMed

11.

Smidt A, Lipovetsky-Adler M, Sharon E: Forced eruption as an alternative to tooth extraction in long-term use of oral bisphosphonates: Review, risks and technique. J Am Dent Assoc. 2012, 143: 1303-12.CrossRefPubMed

12.

Krieger E, d´Hoedt B, Scheller H, Jacobs C, Walter C, Wehrbein H: Orthodontic treatment under Bisphoshonate therapy – A case report. J Orofac Orthop. 2012, 74: 28-39.CrossRef

13.

Rinchuse DJ, Rinchuse DJ, Sosovicka MF, Robison JM, Pendleton R: Orthodontic treatment of patients using bisphosphonates: a report of 2 cases. Am J Orthod Dentofacial Orthop. 2007, 131: 321-6. 10.1016/j.ajodo.2006.11.002.CrossRefPubMed

14.

Zahrowski JJ: Optimizing orthodontic treatment in patients taking bisphosphonates for osteoporosis. Am J Orthod Dentofacial Orthop. 2009, 135: 361-74. 10.1016/j.ajodo.2008.08.017.CrossRefPubMed

15.

Lotwala RB, Greenlee GM, Ott SM, Hall SH, Huang GJ: Bisphosphonates as a risk factor for adverse orthodontic outcomes: a retrospective cohort study. Am J Orthod Dentofacial Orthop. 2012, 142: 625-634. 10.1016/j.ajodo.2012.05.019.CrossRefPubMed

16.

Bartzela T, Türp JC, Motschall E, Maltha JC: Medication effects on the rate of orthodontic tooth movement: a systematic literature review. Am J Orthod Dentofacial Orthop. 2009, 135: 16-26. 10.1016/j.ajodo.2008.08.016.CrossRefPubMed

17.

Walter C, Pabst A, Ziebart T, Klein M, Al-Nawas B: Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro. Oral Dis. 2011, 17: 194-9. 10.1111/j.1601-0825.2010.01720.x.CrossRefPubMed

18.

Alatli I, Hellsing E, Hammarström L: Orthodontically induced root resorption in rat molars after 1-hydroxyethylidene-1.1-bisphosphonate injection. Acta Odontol Scand. 1996, 54: 102-8. 10.3109/00016359609006013.CrossRefPubMed

19.

Choi J, Baek SH, Lee JI, Chang YI: Effects of clodronate on early alveolar bone remodeling and root resorption related to orthodontic forces: a histomorphometric analysis. Am J Orthod Dentofacial Orthop. 2010, 138 (548): e1-8.

20.

Fujimura Y, Kitaura H, Yoshimatsu M, Eguchi T, Kohara H, Morita Y, Yoshida N: Influence of bisphosphonates on orthodontic tooth movement in mice. Eur J Orthod. 2009, 31: 572-7. 10.1093/ejo/cjp068.CrossRefPubMed

21.

Igarashi K, Mitani H, Adachi H, Shinoda H: Anchorage and retentive effects of a bisphosphonate (AHBuBP) on tooth movements in rats. Am J Orthod Dentofacial Orthop. 1994, 106: 279-89. 10.1016/S0889-5406(94)70048-6.CrossRefPubMed

22.

Igarashi K, Adachi H, Mitani H, Shinoda H: Inhibitory effect of the topical administration of a bisphosphonate (risedronate) on root resorption incident to orthodontic tooth movement in rats. J Dent Res. 1996, 75: 1644-9. 10.1177/00220345960750090501.CrossRefPubMed

23.

Liu L, Igarashi K, Haruyama N, Saeki S, Shinoda H, Mitani H: Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats. Eur J Orthod. 2004, 26: 469-73. 10.1093/ejo/26.5.469.CrossRefPubMed

24.

Sirisoontorn I, Hotokezaka H, Hashimoto M, Gonzales C, Luppanapornlarp S, Darendeliler MA, Yoshida N: Orthodontic tooth movement and root resorption in ovariectomized rats treated by systemic administration of zoledronic acid. Am J Orthod Dentofacial Orthop. 2012, 141: 563-73. 10.1016/j.ajodo.2011.11.016.CrossRefPubMed

25.

Karras JC, Miller JR, Hodges JS, Beyer JP, Larson BE: Effect of alendronate on orthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop. 2009, 136: 843-7. 10.1016/j.ajodo.2007.11.035.CrossRefPubMed

Title: Current state of orthodontic patients under Bisphosphonate therapy
Authors: Elena Krieger
Collin Jacobs
Christian Walter
Heinrich Wehrbein
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: Head & Face Medicine / Issue 1/2013
Electronic ISSN: 1746-160X
DOI: https://doi.org/10.1186/1746-160X-9-10

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Current state of orthodontic patients under Bisphosphonate therapy

Abstract

Background

Material and methods

Findings

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Material and methods

Findings

Conclusions

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