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Open Access 01-12-2006 | Research

Salivary flow rate, pH, and concentrations of calcium, phosphate, and sIgA in Brazilian pregnant and non-pregnant women

Authors: Maria I Rockenbach, Sandra A Marinho, Elaine B Veeck, Laura Lindemann, Rosemary S Shinkai

Published in: Head & Face Medicine | Issue 1/2006

Abstract

Background

Studies on salivary variables and pregnancy in Latin America are scarce. This study aimed to compare salivary flow rate, pH, and concentrations of calcium, phosphate, and sIgA of unstimulated whole saliva in pregnant and non-pregnant Brazilians.

Methods

Cross-sectional study. Sample was composed by 22 pregnant and 22 non-pregnant women attending the Obstetrics and Gynecology Clinics, São Lucas Hospital, in Porto Alegre city, South region of Brazil. Unstimulated whole saliva was collected to determine salivary flow rate, pH, and biochemical composition. Data were analyzed by Student t test and ANCOVA (two-tailed α = 0.05).

Results

No difference was found for salivary flow rates and concentrations of total calcium and phosphate between pregnant and non-pregnant women (p > 0.05). Pregnant women had lower pH (6.7) than non-pregnant women (7.5) (p < 0.001), but higher sIgA level (118.9 mg/L) than the latter (90.1 mg/L) (p = 0.026).

Conclusion

Some of the tested variables of unstimulated whole saliva were different between pregnant and non-pregnant Brazilians in this sample. Overall, the values of the tested salivary parameters were within the range of international references of normality.

Salvolini E, Di Giorgio R, Curatola A, Mazzanti L, Fratto G: Biochemical modifications of human whole saliva induced by pregnancy. Br J Obstet Gynaecol. 1998, 105: 656-660.CrossRefPubMed

Rudney JD: Does variability in salivary protein concentrations influence oral microbial ecology and oral health?. Crit Rev Oral Biol Med. 1995, 6: 343-367.CrossRefPubMed

Laine MA: Effect of pregnancy on periodontal and dental health. Acta Odontol Scand. 2002, 60: 257-264. 10.1080/00016350260248210.CrossRefPubMed

Choe JK, Khan-Dawood FS, Dawood MY: Progesterone and estradiol in the saliva and plasma during the menstrual cycle. Am J Obstet Gynecol. 1983, 147: 557-562.CrossRefPubMed

Laine M, Leimola-Virtanen R: Effect of hormone replacement therapy on salivary flow rate, buffer effect and pH on perimenopausal and postmenopausal women. Arch Oral Biol. 1996, 41: 91-96. 10.1016/0003-9969(95)00085-2.CrossRefPubMed

Edgar WM: Saliva: its secretion, composition and functions. Br Dent J. 1992, 172: 305-312.CrossRefPubMed

Pedersen AM, Bardow A, Jensen SB, Nauntofte B: Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 2002, 8: 117-129. 10.1034/j.1601-0825.2002.02851.x.CrossRefPubMed

Thylstrup A, Fejerskov O: Textbook of Clinical Cariology. 1994, Copenhagen: Munksgaard

González M, Montes de Oca L, Jiménez G: [Changes in saliva composition of pregnant and non-pregnant patients]. Perinatol reprod hum. 2001, 15: 195-201. Spanish

10.

D'Alessandro S, Curbelo HM, Tumilasci OR, Tessler JA, Houssay AB: Changes in human parotid salivary protein and sialic acid levels during pregnancy. Arch Oral Biol. 1989, 34: 829-831. 10.1016/0003-9969(89)90035-6.CrossRefPubMed

11.

Atkinson JC: The role of salivary measurements in the diagnosis of salivary autoimmune diseases. Ann N Y Acad Sci. 1993, 694: 238-251.CrossRefPubMed

12.

Shannon IL: Reference for human parotid saliva collected at varying levels of exogenous stimulation. J Dent Res. 1973, 52: 1157-PubMed

13.

Banderas-Tarabay JA, Gonzalez-Begne M, Sanchez-Garduno M, Millan-Cortez E, Lopez-Rodriguez A, Vilchis-Velazquez A: [The flow and concentration of proteins in human whole saliva]. Salud Publica Mex. 1997, 39: 433-441. SpanishCrossRefPubMed

14.

Gitelman HJ: An improved automated procedure for the determination of calcium in biological specimens. Anal Biochem. 1967, 18: 521-531. 10.1016/0003-2697(67)90110-8.CrossRef

15.

Daly JA, Ertingshausen G: Direct method for determining inorganic phosphate in serum with the "CentrifiChem". Clin Chem. 1972, 18: 263-265.PubMed

16.

Mancini G, Carbonara AO, Heremans JF: Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965, 2: 235-254. 10.1016/0019-2791(65)90004-2.CrossRefPubMed

17.

Sreebny LM: Saliva in health and disease: an appraisal and update. Int Dent J. 2000, 50: 140-161.CrossRefPubMed

18.

Kivela J, Laine M, Parkkila S, Rajaniemi H: Salivary carbonic anhydrase VI and its relation to salivary flow rate and buffer capacity in pregnant and non-pregnant women. Arch Oral Biol. 2003, 48: 547-551. 10.1016/S0003-9969(03)00096-7.CrossRefPubMed

19.

Scully C, Bagan JV: Adverse drug reactions in the orofacial region. Crit Rev Oral Biol Med. 2004, 15: 221-239.CrossRefPubMed

20.

Laine M, Pienihakkinen K, Ojanotko-Harri A, Tenovuo J: Effects of low-dose oral contraceptives on female whole saliva. Arch Oral Biol. 1991, 36: 549-552. 10.1016/0003-9969(91)90151-J.CrossRefPubMed

21.

Streckfus CF, Baur U, Brown LJ, Bacal C, Metter J, Nick T: Effects of estrogen status and aging on salivary flow rates in healthy Caucasian women. Gerontology. 1998, 44: 32-39. 10.1159/000021980.CrossRefPubMed

22.

Laine M, Pienihäkkinen K: Salivary buffer effect in relation to late pregnancy and postpartum. Acta Odontol Scand. 2000, 58: 8-10. 10.1080/000163500429361.CrossRefPubMed

23.

Laine M, Tenovuo J, Lehtonen OP, Ojanotko-Harri A, Vilja P, Tuohimaa P: Pregnancy-related changes in human whole saliva. Arch Oral Biol. 1988, 33: 913-917. 10.1016/0003-9969(88)90022-2.CrossRefPubMed

24.

Widerstrom L, Bratthall D: Increased IgA levels in saliva during pregnancy. Scand J Dent Res. 1984, 92: 33-37.PubMed

25.

Mandel ID: Sialochemistry in diseases and clinical situations affecting salivary glands. Crit Rev Clin Lab Sci. 1980, 12: 321-366.CrossRefPubMed

26.

Dawes C: Factors influencing salivary flow rate and composition. Saliva and oral health. Edited by: Edgar M, Dawes C, O'Mullane D. 2004, London: British Dental Association, 32-49. 3

27.

Teeuw W, Bosch JA, Veerman EC, Amerongen AV: Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health. Biol Chem. 2004, 385: 1137-1146. 10.1515/BC.2004.147.CrossRefPubMed

28.

Lawrence HP: Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health. J Can Dent Assoc. 2002, 68: 170-174.PubMed

Title: Salivary flow rate, pH, and concentrations of calcium, phosphate, and sIgA in Brazilian pregnant and non-pregnant women
Authors: Maria I Rockenbach
Sandra A Marinho
Elaine B Veeck
Laura Lindemann
Rosemary S Shinkai
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: Head & Face Medicine / Issue 1/2006
Electronic ISSN: 1746-160X
DOI: https://doi.org/10.1186/1746-160X-2-44

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Salivary flow rate, pH, and concentrations of calcium, phosphate, and sIgA in Brazilian pregnant and non-pregnant women

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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