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Open Access 01-12-2012 | Research

Laminin-5 is a biomarker of invasiveness in cervical adenocarcinoma

Authors: Johji Imura, Yoshiaki Uchida, Kazuhiro Nomoto, Kazuhito Ichikawa, Shigeki Tomita, Tatsuo Iijima, Takahiro Fujimori

Published in: Diagnostic Pathology | Issue 1/2012

Abstract

Background

Glandular lesions are often problematic for diagnostic cervical pathology. The survival of patients with adenocarcinoma is significantly poorer than that of patient with squamous cell carcinoma. One reason for this increased risk is the aggressive invasiveness of adenocarcinoma. Therefore additional biomarkers, to supplement morphological diagnosis of adenocarcinoma, are necessary. We have assessed the diagnostic utility of Laminin-5 (Laminin γ2 chain): Lam-5 in the diagnosis of the invasiveness of cervical adenocarcinoma and related glandular lesions.

Methods

Lam-5 immunohistochemistry was performed on archival specimens from 8 patients with uterine leiomyoma as a negative control group, 6 patients with endocervical gland hyperplasia, 6 patients with adenocarcinoma in situ, 6 patients with microinvasive adenocarcinoma and 24 patients with invasive adenocarcinoma.

Results

The expression of Lam-5 was not detected in normal mucosa, but was seen along the basement membrane in endocervical gland hyperplasia and adenocarcinoma in situ and was observed in the cytoplasm of tumor cells in microinvasive and invasive adenocarcinoma.

Conclusion

We conclude that Lam-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma.

Virtual slides

The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/7316562925827381

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Title: Laminin-5 is a biomarker of invasiveness in cervical adenocarcinoma
Authors: Johji Imura
Yoshiaki Uchida
Kazuhiro Nomoto
Kazuhito Ichikawa
Shigeki Tomita
Tatsuo Iijima
Takahiro Fujimori
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2012
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-7-105

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Laminin-5 is a biomarker of invasiveness in cervical adenocarcinoma

Abstract

Background

Methods

Results

Conclusion

Virtual slides

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Virtual slides

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