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Diagnostic Pathology

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Open Access 01-12-2010 | Research

Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue

Authors: Peng Su, Qinghui Zhang, Qifeng Yang

Published in: Diagnostic Pathology | Issue 1/2010

Abstract

Background

Metadherin (MTDH) has been reported to be associated with cancer progression in various types of human cancers including breast cancer. Whether MTDH contributes to carcinogenesis of breast cancer is still unknown. In the present study, we investigated the expression of MTDH in normal, UDH (usual ductal hyperplasia), ADH (atypical ductal hyperplasia), DCIS (ductal carcinoma in situ) and invasive cancer to explore the possible role of MTDH for breast cancer carcinogenesis.

Methods

Immunohistochemistry was employed on paraffin sections of surgical removed breast samples.

Results

The immunohistochemical results showed almost no staining in normal tissue, moderate staining in ADH and UDH, intense MTDH stains in DCIS and cancer. Statistical analysis demonstrated significant different MTDH expression between proliferative and cancerous breast lesions (p < 0.001). MTDH was positively correlated with the histological differentiation of DCIS (p = 0.028). In breast cancer, statistical analysis revealed a significant correlation between MTDH expression with patients' age (p = 0.042), ER status (p = 0.018) and p53 status (p = 0.001). We also examined the effect of MTDH on cell proliferation in DCIS and cancer, and we found that MTDH overexpression was significantly correlated with high Ki67 index (p = 0.008 and p = 0.036, respectively).

Conclusions

MTDH overexpression could be identified in proliferative breast lesions and may contribute to breast cancer progression.

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Title: Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue
Authors: Peng Su
Qinghui Zhang
Qifeng Yang
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2010
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-5-38

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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