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Diagnostic Pathology
Published in: Diagnostic Pathology 1/2009

Open Access 01-12-2009 | Review

Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited

Authors: Yashwant Kumar, Alka Bhatia, Ranjana Walker Minz

Published in: Diagnostic Pathology | Issue 1/2009

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Abstract

It has been more than 50 years since antinuclear antibodies were first discovered and found to be associated with connective tissue diseases. Since then different methods have been described and used for their detection or confirmation. For many decades immunofluorescent antinuclear antibody test has been the "gold standard" in the diagnosis of these disorders. However to increase the sensitivity and specificity of antinuclear antibody detection further approaches were explored. Today a battery of newer techniques are available some of which are now considered better and are competing with the older methods. This article provides an overview on advancement in antinuclear antibody detection methods, their future prospects, advantages, disadvantages and guidelines for use of these tests.
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Metadata
Title
Antinuclear antibodies and their detection methods in diagnosis of connective tissue diseases: a journey revisited
Authors
Yashwant Kumar
Alka Bhatia
Ranjana Walker Minz
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2009
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/1746-1596-4-1

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