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Journal of Occupational Medicine and Toxicology
Published in: Journal of Occupational Medicine and Toxicology 1/2013

Open Access 01-12-2013 | Research

Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease

Authors: Jochen Springer, Frank R Scholz, Christian Peiser, Q Thai Dinh, Axel Fischer, David Quarcoo, David A Groneberg

Published in: Journal of Occupational Medicine and Toxicology | Issue 1/2013

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Abstract

Background

Tobacco is a leading environmental factor in the initiation of respiratory diseases and causes chronic obstructive pulmonary disease (COPD). Suppressor of cytokine signaling (SOCS) family members are involved in the pathogenesis of many inflammatory diseases and SOCS-3 has been shown to play an important role in the regulation, onset and maintenance of airway allergic inflammation indicating that SOCS-3 displays a potential therapeutic target for anti-inflammatory respiratory drugs development. Since chronic obstructive pulmonary disease (COPD) is also characterized by inflammatory changes and airflow limitation, the present study assessed the transcriptional expression of SOCS-3 in COPD.

Methods

Real-time PCR was performed to assess quantitative changes in bronchial biopsies of COPD patients in comparison to unaffected controls.

Results

SOCS-3 was significantly down-regulated in COPD at the transcriptional level while SOCS-4 and SOCS-5 displayed no change.

Conclusions

It can be concluded that the presently observed inhibition of SOCS-3 mRNA expression may be related to the dysbalance of cytokine signaling observed in COPD.
Appendix
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Literature
1.
2.
3.
4.
Baur X, Barbinova L: Occupational airborne exposure, specific sensitization and the atopic status: evidence of a complex interrelationship. J Occup Med Toxicol 2013, 8: 2.PubMedCentralCrossRefPubMed
5.
Alexopoulos EC, Bouros D, Dimadi M, Serbescu A, Bakoyannis G, Kokkinis FP: Comparative analysis of induced sputum and bronchoalveolar lavage fluid (BALF) profile in asbestos exposed workers. J Occup Med Toxicol 2011, 6: 23.PubMedCentralCrossRefPubMed
6.
Nienhaus A, Costa JT: Screening for tuberculosis and the use of a borderline zone for the interpretation of the interferon-gamma release assay (IGRA) in Portuguese healthcare workers. J Occup Med Toxicol 2013, 8: 1.PubMedCentralCrossRefPubMed
7.
Moucaut A, Nienhaus A, Courtois B, Nael V, Longuenesse C, Ripault B, Rucay P, Moisan S, Roquelaure Y, Tripodi D: The effect of introducing IGRA to screen French healthcare workers for tuberculosis and potential conclusions for the work organisation. J Occup Med Toxicol 2013, 8: 12.PubMedCentralCrossRefPubMed
8.
Baur X, Bakehe P, Vellguth H: Bronchial asthma and COPD due to irritants in the workplace - an evidence-based approach. J Occup Med Toxicol 2012, 7: 19.PubMedCentralCrossRefPubMed
9.
Chung KF, Groneberg DA: Effects of cigarette smoke on pulmonary homeostasis. Am J Respir Cell Mol Biol 2005, 32: 167.CrossRefPubMed
10.
11.
Chung KF: Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl 2001, 34: 50s-59s.CrossRefPubMed
12.
Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A: SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem 2004, 385: 649–653.CrossRefPubMed
13.
Groneberg DA, Witt H, Adcock IM, Hansen G, Springer J: Smads as intracellular mediators of airway inflammation. Exp Lung Res 2004, 30: 223–250.CrossRefPubMed
14.
Dalpke A, Heeg K: Suppressors of cytokine signaling proteins in innate and adaptive immune responses. Arch Immunol Ther Exp (Warsz) 2003, 51: 91–103.
15.
Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A: A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. Embo J 1995, 14: 2816–2826.PubMedCentralPubMed
16.
Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ: A family of cytokine-inducible inhibitors of signalling. Nature 1997, 387: 917–921.CrossRefPubMed
17.
Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, et al.: Cloning and characterization of novel CIS family genes. Biochem Biophys Res Commun 1997, 239: 439–446.CrossRefPubMed
18.
19.
Shouda T, Yoshida T, Hanada T, Wakioka T, Oishi M, Miyoshi K, Komiya S, Kosai K, Hanakawa Y, Hashimoto K, et al.: Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest 2001, 108: 1781–1788.PubMedCentralCrossRefPubMed
20.
Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, Kubo M, Yamashita A, Okabe M, Takeda K, et al.: CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001, 193: 471–481.PubMedCentralCrossRefPubMed
21.
Gao H, Ward PA: STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses. Expert Opin Ther Targets 2007, 11: 869–880.CrossRefPubMed
22.
Groneberg DA, Peiser C, Eynott PR, Welker P, Erbes R, Witt C, Chung KF, Fischer A: Transcriptional down-regulation of neurotrophin-3 in chronic obstructive pulmonary disease. Biol Chem 2005, 386: 53–59.CrossRefPubMed
23.
Gomez FP, Rodriguez-Roisin R: Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for chronic obstructive pulmonary disease. Curr Opin Pulm Med 2002, 8: 81–86.CrossRefPubMed
24.
Pauwels RA, Buist AS, Ma P, Jenkins CR, Hurd SS: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: National Heart, Lung, and Blood Institute and World Health Organization Global Initiative for Chronic Obstructive Lung Disease (GOLD): executive summary. Respir Care 2001, 46: 798–825.PubMed
25.
Lim S, Groneberg D, Fischer A, Oates T, Caramori G, Mattos W, Adcock I, Barnes PJ, Chung KF: Expression of heme oxygenase isoenzymes 1 and 2 in normal and asthmatic airways: effect of inhaled corticosteroids. Am J Respir Crit Care Med 2000, 162: 1912–1918.CrossRefPubMed
26.
Fischer TC, Dinh QT, Peiser C, Loser C, Fischer A, Groneberg DA: Simultaneous detection of receptor mRNA and ligand protein in human skin tissues. J Cutan Pathol 2002, 29: 65–71.CrossRefPubMed
27.
Groneberg DA, Heppt W, Welker P, Peiser C, Dinh QT, Cryer A, Zweng M, Witt C, Fischer A: Aspirin-sensitive rhinitis associated changes in upper airway innervation. Eur Respir J 2003, 22: 986–991.CrossRefPubMed
28.
Fischer TC, Hartmann P, Loser C, Springer J, Peiser C, Dinh QT, Fischer A, Groneberg DA: Abundant expression of vasoactive intestinal polypeptide receptor VPAC2 mRNA in human skin. J Invest Dermatol 2001, 117: 754–756.CrossRefPubMed
29.
Groneberg DA, Peiser C, Dinh QT, Springer J, Fischer A: Abundant expression of c-Jun in guinea pig sympathetic ganglia under basal conditions and allergen challenge. Lung 2002, 180: 221–228.CrossRefPubMed
30.
Grosse-Siestrup C, Wiemer PM, Fischer TC, Fehrenberg C, Unger V, Fischer A, Groneberg DA: Isolated hemoperfused porcine skin as a valid model to assess percutaneous absorption. J Invest Dermatol 2002, 119: 197–199.CrossRefPubMed
31.
Groneberg DA, Heppt W, Cryer A, Wussow A, Peiser C, Zweng M, Dinh QT, Witt C, Fischer A: Toxic rhinitis-induced changes of human nasal mucosa innervation. Toxicol Pathol 2003, 31: 326–331.CrossRefPubMed
32.
Lagente V, Advenier C: Tachykinins and airway function. Pulm Pharmacol Ther 1998, 11: 331–340.CrossRef
33.
Heppt W, Thai Dinh Q, Cryer A, Zweng M, Noga O, Peiser C, Melvan M, Witt C, Fischer A, Groneberg DA: Phenotypic alteration of neuropeptide-containing nerve fibres in seasonal intermittent allergic rhinitis. Clin Exp Allergy 2004, 34: 1105–1110.CrossRefPubMed
34.
35.
Eynott PR, Groneberg DA, Caramori G, Adcock IM, Donnelly LE, Kharitonov S, Barnes PJ, Chung KF: Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. Eur J Pharmacol 2002, 452: 123–133.CrossRefPubMed
36.
Eynott PR, Paavolainen N, Groneberg DA, Noble A, Salmon M, Nath P, Leung SY, Chung KF: Role of nitric oxide in chronic allergen-induced airway cell proliferation and inflammation. J Pharmacol Exp Ther 2003, 304: 22–29.CrossRefPubMed
37.
Nicosia S, Capra V, Rovati GE: Leukotrienes as mediators of asthma. Pulm Pharmacol Ther 2001, 14: 3–19.CrossRefPubMed
38.
Groneberg DA, Fischer A: Endogenous opioids as mediators of asthma. Pulm Pharmacol Ther 2001, 14: 383–389.CrossRefPubMed
39.
Huang HY, Lai YL: Lipopolysaccharide induces preprotachykinin gene expression. Am J Respir Cell Mol Biol 2003, 29: 606–612.CrossRefPubMed
40.
Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ: Tissue-specific induction of SOCS gene expression by PRL. Endocrinology 2001, 142: 5015–5026.CrossRefPubMed
41.
Arakawa S, Hatano Y, Katagiri K: Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis. Clin Exp Immunol 2004, 135: 505–510.PubMedCentralCrossRefPubMed
42.
Nasreen N, Khodayari N, Sukka-Ganesh B, Peruvemba S, Mohammed KA: Fluticasone propionate and Salmeterol combination induces SOCS-3 expression in airway epithelial cells. Int Immunopharmacol 2012, 12: 217–225.CrossRefPubMed
43.
Seki Y, Inoue H, Nagata N, Hayashi K, Fukuyama S, Matsumoto K, Komine O, Hamano S, Himeno K, Inagaki-Ohara K, et al.: SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med 2003, 9: 1047–1054.CrossRefPubMed
44.
Saetta M, Baraldo S, Corbino L, Turato G, Braccioni F, Rea F, Cavallesco G, Tropeano G, Mapp CE, Maestrelli P, et al.: CD8 + ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999, 160: 711–717.CrossRefPubMed
45.
Saetta M, Di Stefano A, Maestrelli P, Ferraresso A, Drigo R, Potena A, Ciaccia A, Fabbri LM: Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am Rev Respir Dis 1993, 147: 301–306.CrossRefPubMed
46.
Saetta M, Di Stefano A, Turato G, Facchini FM, Corbino L, Mapp CE, Maestrelli P, Ciaccia A, Fabbri LM: CD T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998, 157: 822–826.CrossRefPubMed
47.
Stanescu D, Sanna A, Veriter C, Kostianev S, Calcagni PG, Fabbri LM, Maestrelli P: Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils. Thorax 1996, 51: 267–271.PubMedCentralCrossRefPubMed
48.
Majo J, Ghezzo H, Cosio MG: Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. Eur Respir J 2001, 17: 946–953.CrossRefPubMed
49.
Retamales I, Elliott WM, Meshi B, Coxson HO, Pare PD, Sciurba FC, Rogers RM, Hayashi S, Hogg JC: Amplification of inflammation in emphysema and its association with latent adenoviral infection. Am J Respir Crit Care Med 2001, 164: 469–473.CrossRefPubMed
50.
O'Shaughnessy TC, Ansari TW, Barnes NC, Jeffery PK: Inflammation in bronchial biopsies of subjects with chronic bronchitis: Inverse relationship of CD8 T lymphocytes with FEV1. Am J Respir Crit Care Med 1997, 155: 852–857.CrossRefPubMed
51.
Sutherland ER, Martin RJ: Airway inflammation in chronic obstructive pulmonary disease*1: Comparisons with asthma. J Allergy Clin Immunol 2003, 112: 819–827.CrossRefPubMed
52.
Fabbri LM, Romagnoli M, Corbetta L, Casoni G, Busljetic K, Turato G, Ligabue G, Ciaccia A, Saetta M, Papi A: Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003, 167: 418–424.CrossRefPubMed
53.
Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN: SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell 1999, 98: 617–627.CrossRefPubMed
54.
Roberts AW, Robb L, Rakar S, Hartley L, Cluse L, Nicola NA, Metcalf D, Hilton DJ, Alexander WS: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A 2001, 98: 9324–9329.PubMedCentralCrossRefPubMed
55.
Peiser C, Springer J, Groneberg DA, McGregor GP, Fischer A, Lang RE: Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus. Neurosci Lett 2002, 320: 41–44.CrossRefPubMed
56.
Groneberg DA, Doring F, Nickolaus M, Daniel H, Fischer A: Expression of PEPT2 peptide transporter mRNA and protein in glial cells of rat dorsal root ganglia. Neurosci Lett 2001, 304: 181–184.CrossRefPubMed
57.
Groneberg DA, Eynott PR, Doring F, Dinh QT, Oates T, Barnes PJ, Chung KF, Daniel H, Fischer A: Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax 2002, 57: 55–60.PubMedCentralCrossRefPubMed
58.
Dinh QT, Groneberg DA, Peiser C, Mingomataj E, Joachim RA, Witt C, Arck PC, Klapp BF, Fischer A: Substance P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung. Respir Physiol Neurobiol 2004, 144: 15–24.CrossRefPubMed
59.
Rost B, Hanf G, Ohnemus U, Otto-Knapp R, Groneberg DA, Kunkel G, Noga O: Monocytes of allergics and non-allergics produce, store and release the neurotrophins NGF, BDNF and NT-3. Regul Pept 2005, 124: 19–25.CrossRefPubMed
60.
de Vries A, Engels F, Henricks PA, Leusink-Muis T, McGregor GP, Braun A, Groneberg DA, Dessing MC, Nijkamp FP, Fischer A: Airway hyper-responsiveness in allergic asthma in guinea-pigs is mediated by nerve growth factor via the induction of substance P: a potential role for trkA. Clin Exp Allergy 2006, 36: 1192–1200.CrossRefPubMed
Metadata
Title
Transcriptional down-regulation of suppressor of cytokine signaling (SOCS)-3 in chronic obstructive pulmonary disease
Authors
Jochen Springer
Frank R Scholz
Christian Peiser
Q Thai Dinh
Axel Fischer
David Quarcoo
David A Groneberg
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Journal of Occupational Medicine and Toxicology / Issue 1/2013
Electronic ISSN: 1745-6673
DOI
https://doi.org/10.1186/1745-6673-8-29

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