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Open Access 01-12-2007 | Short paper

Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging

Authors: Susanne Brummelte, Gertraud Teuchert-Noodt

Published in: Behavioral and Brain Functions | Issue 1/2007

Abstract

Mesencephalic dopamine (DA) projections are essential for cognitive and behavioral functions and believed to play a critical role during development and aging. The dopaminergic afferents of the rodent prefrontal cortex (PFC) show an extremely prolonged maturation which is very sensitive to epigenetic challenges. However, less is known about the long-term maturation and aging of these DA axons. Therefore, immunohistochemically stained DA fibres were quantitatively examined in the PFC of the Mongolian gerbil (Meriones unguiculatus) ranging from 6 to 24 months of age. Results show a decrease in DA fibre densities in the superficial layers of the PFC in 24 month old animals compared to 6 and 12 months.

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Title: Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging
Authors: Susanne Brummelte
Gertraud Teuchert-Noodt
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Behavioral and Brain Functions / Issue 1/2007
Electronic ISSN: 1744-9081
DOI: https://doi.org/10.1186/1744-9081-3-14

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Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging

Abstract

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