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Open Access 01-12-2007 | Review

p38 MAPK, microglial signaling, and neuropathic pain

Authors: Ru-Rong Ji, Marc R Suter

Published in: Molecular Pain | Issue 1/2007

Abstract

Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We will discuss the upstream mechanisms causing p38 activation in spinal microglia after nerve injury. We will also discuss the downstream mechanisms by which p38 produces inflammatory mediators. Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management.

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Title: p38 MAPK, microglial signaling, and neuropathic pain
Authors: Ru-Rong Ji
Marc R Suter
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Molecular Pain / Issue 1/2007
Electronic ISSN: 1744-8069
DOI: https://doi.org/10.1186/1744-8069-3-33

Keynote webinar | Spotlight on medication adherence

Springer Medicine

p38 MAPK, microglial signaling, and neuropathic pain

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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