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Published in: Immunity & Ageing 1/2007

Open Access 01-12-2007 | Review

Role of persistent CMV infection in configuring T cell immunity in the elderly

Authors: Sonya Vasto, Giuseppina Colonna-Romano, Anis Larbi, Anders Wikby, Calogero Caruso, Graham Pawelec

Published in: Immunity & Ageing | Issue 1/2007

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Abstract

Ageing is associated with declines in many physiological parameters, including multiple immune system functions. The rate of acceleration of the frequency of death due to cardiovascular disease or cancer seems to increase with age from middle age up to around 80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are often associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have been suggested as biomarkers of immune system aging. Thus, the manner in which CMV and the host immune system interact is critical in determining the "age" of specific immunity. We may therefore consider immunosenescence in some respects as an infectious state. This implies that interventions aimed at the pathogen may improve the organ system affected. Hence, CMV-directed anti-virals or vaccination may have beneficial effects on immunity in later life.
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Metadata
Title
Role of persistent CMV infection in configuring T cell immunity in the elderly
Authors
Sonya Vasto
Giuseppina Colonna-Romano
Anis Larbi
Anders Wikby
Calogero Caruso
Graham Pawelec
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2007
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/1742-4933-4-2

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