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BMC Medicine
Published in: BMC Medicine 1/2011

Open Access 01-12-2011 | Review

Clinical trials for stem cell therapies

Authors: Alan Trounson, Rahul G Thakar, Geoff Lomax, Don Gibbons

Published in: BMC Medicine | Issue 1/2011

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Abstract

In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. Early results from these trials have produced mixed results often showing minor or transitory improvements that may be attributed to extracellular factors. More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. At the same time, the first three trials using cells derived from pluripotent cells have begun.
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Metadata
Title
Clinical trials for stem cell therapies
Authors
Alan Trounson
Rahul G Thakar
Geoff Lomax
Don Gibbons
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2011
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-9-52

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