Published in:
Open Access
01-09-2014 | Poster presentation
Elicitation of expert prior opinion: application to the mypan trial in childhood polyarteritis nodosa
Authors:
Lisa Hampson, John Whitehead, Despina Eleftheriou, Catherine Tudur-Smith, Rachel Jones, David Jayne, Helen Hickey, Paul Brogan, MYPAN vasculitis expert group
Published in:
Pediatric Rheumatology
|
Special Issue 1/2014
Login to get access
Excerpt
A major challenge in rare diseases is conducting clinical trials with sufficient power to inform best clinical practice when anticipated sample sizes are small. Historically, this has been a major barrier in rare paediatric autoimmune diseases. Bayesian methodology can be used to augment the sparse therapeutic data obtained from clinical trials in these circumstances. …