Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Thrombosis Journal
Published in: Thrombosis Journal 1/2007

Open Access 01-12-2007 | Review

Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications

Authors: Massimo Franchini, Franco Capra, Giovanni Targher, Martina Montagnana, Giuseppe Lippi

Published in: Thrombosis Journal | Issue 1/2007

Login to get access

Abstract

Although a number of studies have demonstrated the influence of ABO blood group on plasma levels of von Willebrand factor (VWF), the nature of this association and its clinical importance is still largely unknown.
In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed.
Literature
1.
Ruggeri ZM, Zimmerman TS: The complex multimeric composition of factor VIII/vWF. Blood 1981, 57: 1140-1143.PubMed
2.
Sadler JE: von Willebrand factor. Ann Rev Biochem 1998, 67: 395-424. 10.1146/annurev.biochem.67.1.395CrossRefPubMed
3.
Ruggeri ZM: Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation. Best Pract ResClinical Haematol 2001, 14: 257-259. 10.1053/beha.2001.0133CrossRef
4.
Vlot AJ, Koppelman SJ, Bouma BN, Sixma JJ: Factor VIII and von Willebrand Factor. Thromb Haemost 1998, 79: 456-465.PubMed
5.
Ruggeri ZM, Zimmerman TS: von Willebrand factor and von Willebrand disease. Blood 1987, 70: 895-904.PubMed
6.
Whincup PH, Danesh J, Walker M, Lennon L, Thomson A, Appleby P, Rumley A, Lowe GD: von Willebrand factor and coronary heart disease: prospective study and meta-analysis. Eur Heart J 2002, 23: 1764-1770. 10.1053/euhj.2001.3237CrossRefPubMed
7.
Franchini M, Lippi G: Von Willebrand factor and thrombosis. Ann Hematol 2006, 85: 415-423. 10.1007/s00277-006-0085-5CrossRefPubMed
8.
O'Donnell JS, Lasffan MA: The relationship between ABO histo-blood group, factor VIII and von Willebrand factor. Transfus Med 2001, 11: 343-351. 10.1046/j.1365-3148.2001.00315.xCrossRefPubMed
9.
Jenkins PV, O'Donnell JS: ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? Transfusion 2006, 46: 1836-1844. 10.1111/j.1537-2995.2006.00975.xCrossRefPubMed
10.
Lowe J: The blood group-specific human glycosyltransferases. Baillieres Clin Haematol 1993, 6: 465-490. 10.1016/S0950-3536(05)80155-6CrossRefPubMed
11.
Gastineau DA, Moore SB: How important are ABO-related variations in coagulation factor levels? Transfusion 2001, 41: 4-5. 10.1046/j.1537-2995.2001.41010004.xCrossRefPubMed
12.
McCallum CJ, Peake IR, Newcombe RG, Bloom AL: Factor VIII levels and blood group antigens. Thromb Haemost 1983, 50: 757.PubMed
13.
Mohanty D, Ghosh K, Marwaha N, Kaur S, Chauhan AP, Das KC: Major blood group antigens – a determinant of factor VIII levels in blood? Thromb Haemost 1984, 51: 414.PubMed
14.
Orstavik KH, Magnus P, Reisner H, Berg K, Graham JB, Nance W: Factor VIII and factor IX in a twin population: evidence for a major effect of ABO locus on factor VIII level. Am J Hum Genet 1985, 37: 89-101.PubMedCentralPubMed
15.
Gill JC, Endres-Brooks J, Bauer PJ, Marks WJ Jr, Montgomery RR: The effect of ABO blood group on the diagnosis of von Willebrand disease. Blood 1987, 69: 1691-1695.PubMed
16.
Nitu-Whalley IC, Lee CA, Griffioen A, Jenkins PV, Pasi KJ: Type 1 von Willebrand disease – a clinical retrospective study of the diagnosis, the influence of the ABO blood group and the role of the bleeding history. Br J Haematol 2000, 108: 259-264. 10.1046/j.1365-2141.2000.01830.xCrossRefPubMed
17.
Moeller A, Weippert-Kretschmer M, Prinz H, Kretschmer V: Influence of ABO blood groups on primary hemostasis. Transfusion 2001, 41: 56-60. 10.1046/j.1537-2995.2001.41010056.xCrossRefPubMed
18.
Miller CH, Haff E, Platt SJ, Rawlins P, Drews CD, Dilley AB, Evatt B: Measurement of von Willebrand factor activity: relative effects of ABO blood type and race. J Thromb Haemost 2003, 1: 2191-2197. 10.1046/j.1538-7836.2003.00367.xCrossRefPubMed
19.
Shima M, Fujimura Y, Nishiyama T, Tsujiuchi T, Narita N, Matsui T, Titani K, Katayama M, Yamamoto F, Yoshioka A: ABO blood group genotype and plasma von Willebrand factor in normal individuals. Vox Sang 1995, 68: 236-240.CrossRefPubMed
20.
Souto JC, Almasy L, Muniz-Diaz E, Soria JM, Borrell M, Bayen L, Mateo J, Madoz P, Stone W, Blangero J, Fontcuberta J: Functional effects of the ABO locus polymorphism on plasma levels of von Willebrand factor, factor VIII, and activated partial thromboplastin time. Arterioscler Thromb Vasc Biol 2000, 20: 2024-2028.CrossRefPubMed
21.
Sousa CM, Anicchino-Bizzacchi JM, Locatelli MF, Catsro V, Barjas-Castro L: The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor. Haematologica 2007, 92: 236-239.CrossRefPubMed
22.
O'Donnell J, Boulton FE, Manning RA, Laffan MA: Genotype at the secretor blood group locus is a determinant of plasma von Willebrand factor level. Br J Haematol 2002, 116: 350-356. 10.1046/j.1365-2141.2002.03270.xCrossRefPubMed
23.
Matsui T, Titani K, Mizuochi T: Structures of the asparagine-linked oligosaccharide chains of human von Willebrand factor. Occurrence of blood group A, B, and H(O) structures. J Biol Chem 1992, 267: 8723-8731.PubMed
24.
Mohlke KL, Purkayastha AA, Westrick RJ, Smith PL, Petryniak B, Lowe JB, Ginsburg D: Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Cell 1999, 96: 111-120. 10.1016/S0092-8674(00)80964-2CrossRefPubMed
25.
O'Donnell J, Boulton FE, Manning RA, Laffan MA: Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels. Arterioscler Thromb Vasc Biol 2002, 22: 335-341. 10.1161/hq0202.103997CrossRefPubMed
26.
Morelli VM, de Visser MC, van Tilburg NH, Vos HL, Eikenboom JC, Rosendaal FR, Bertina RM: ABO blood group genotypes, plasma von Willebrand factor levels and loading of von Willebrand factor with A and B antigens. Thromb Haemost 2007, 97: 534-541.PubMed
27.
Sarode R, Goldstein J, Sussman II, Nagel RL, Tsai HM: Role of A and B blood group antigens in the expression of adhesive activity of von Willebrand factor. Br J Haematol 2000, 109: 857-64. 10.1046/j.1365-2141.2000.02113.xCrossRefPubMed
28.
Lenting PJ, van Schooten CJM, Denis CV: Clearance mechanisms of von Willebrand factor and factor VIII. J Thromb Haemost 2007, 5: 1353-1360. 10.1111/j.1538-7836.2007.02572.xCrossRefPubMed
29.
Brown SA, Eldridge A, Collins PW, Bowen DJ: Increased clearance of von Willebrand factor antigen post-DDAVP in Type 1 von Willebrand disease: is it a potential pathogenic process? J Thromb Haemost 2003, 1: 1714-1717. 10.1046/j.1538-7836.2003.00359.xCrossRefPubMed
30.
Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD: Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci USA 2002, 99: 10042-10047. 10.1073/pnas.142005099PubMedCentralCrossRefPubMed
31.
Sodetz JM, Pizzo SV, McKee PA: Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein. J Biol Chem 1977, 252: 5538-5546.PubMed
32.
Nossent AY, van Marion V, van Tilburg NH, Rosendaal FR, Bertina RM, van Mourik JA, Eikenboom HC: von Willebrand factor and its propeptide: the influence of secretion and clearance on protein levels and the risk of venous thrombosis. J Thromb Haemost 2006, 4: 2256-2262. 10.1111/j.1538-7836.2006.02273.xCrossRef
33.
Vlot AJ, Mauser-Bunschoten EP, Zarkova AG, Haan E, Kruitwagen CL, Sixma JJ, van den Berg HM: The half-life of infused factor VIII is shorter in hemophiliac patients with blood group O than in those with blood group A. Thromb Haemost 2000, 83: 65-69.PubMed
34.
O'Donnell JS, McKinnon TA, Crawley JT, Lane DA, Laffan MA: Bombay phenotype is associated with reduced plasma-VWF levels and an increased susceptibility to ADAMTS13 proteolysis. Blood 2005, 106: 1988-1991. 10.1182/blood-2005-02-0792CrossRefPubMed
35.
Bowen DJ: An influence of ABO blood group on the rate of proteolysis of von Willebrand factor by ADAMTS13. J Thromb Haemost 2003, 1: 33-40. 10.1046/j.1538-7836.2003.00007.xCrossRefPubMed
36.
Federici AB, Elder JH, De Marco L, Ruggeri ZM, Zimmerman TS: Carbohydrate moiety of von Willebrand factor is not necessary for maintaining multimeric structure and ristocetin cofactor activity but protects from proteolytic degradation. J Clin Invest 1984, 74: 2049-2055.PubMedCentralCrossRefPubMed
37.
38.
Evans D, Horwich L, McConnell R, Bullen M: Influence of the ABO blood groups and secretor status on bleeding and on perforation of duodenal ulcer. Gut 1968, 9: 319-322. 10.1136/gut.9.3.319PubMedCentralCrossRefPubMed
39.
Ionescu DA, Ghitescu M, Marcu I, Xenakis A: Erythrocyte rheology in acute cerebral thrombosis. Effects of ABO blood groups. Blut 1979, 39: 351-357. 10.1007/BF01014198CrossRefPubMed
40.
Meade TW, Cooper JA, Stirling Y, Howarth DJ, Ruddock V, Miller GJ: Factor VIII, ABO blood group and the incidence of ischaemic heart disease. Br J Haematol 1994, 88: 601-607.CrossRefPubMed
41.
42.
Garrison RJ, Havlik RJ, Harris RB, Feinleib M, Kannel WB, Padgett SJ: ABO blood group and cardiovacular disease: the Framingham study. Atheroslerosis 1976, 25: 311-318. 10.1016/0021-9150(76)90036-8CrossRef
43.
Jager A, van Hinsbergh VW, Kostense PJ, Emeis JJ, Yudkin JS, Nijpels G, Dekker JM, Heine RJ, Bouter LM, Stehouwer CD: von Willebrand factor, C-reactive protein, and 5-year mortality in diabetic and nondiabetic subjects: the Hoorn Study. Arterioscler Thromb Vasc Biol 1999, 19: 3071-3078.CrossRefPubMed
44.
Jick H, Slone D, Westerholm B, Inman WH, Vessey MP, Shapiro S, Lewis GP, Worcester J: Venous thromboembolic disease and ABO blood type. A cooperative study. Lancet 1969, 1: 539-542. 10.1016/S0140-6736(69)91955-2CrossRefPubMed
45.
Wautrecht JC, Galle C, Motte S, Dereume JP, Dramaix M: The role of ABO blood groups in the incidence of deep vein thrombosis. Thromb Haemost 1998, 79: 668-669.
46.
Larsen TB, Johnsen SP, Gislum M, Moller CA, Larsen H, Sorensen HT: ABO blood groups and risk of venous thromboembolism during pregnancy and the puerperium. A population-based, nested case-control study. J Thromb Haemost 2005, 3: 300-304. 10.1111/j.1538-7836.2005.01195.xCrossRefPubMed
47.
Schleef M, Strobel E, Dick A, Frank J, Schramm W, Spannagl M: Relationship between ABO and Secretor genotype with plasma levels of factor VIII and von Willebrand factor in thrombosis patients and control individuals. Br J Haematol 2004, 128: 100-107. 10.1111/j.1365-2141.2004.05249.xCrossRef
48.
Morelli VM, De Visser MC, Vos HL, Bertina RM, Rosendaal FR: ABO blood group genotypes and the risk of venous thrombosis: effect of factor V Leiden. Thromb Haemost 2005, 3: 183-185. 10.1111/j.1538-7836.2004.01071.xCrossRef
49.
Koster T, Blann AD, Briet E, Vandenbroucke JP, Rosendaal FR: Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995, 345: 152-155. 10.1016/S0140-6736(95)90166-3CrossRefPubMed
50.
Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE: Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 1997, 96: 1102-1108.CrossRefPubMed
51.
Vischer UM: Von Willebrand factor, endothelial dysfunction, and cardiovascular disease. J Thromb Haemost 2006, 4: 1186-1193. 10.1111/j.1538-7836.2006.01949.xCrossRefPubMed
52.
Tirado I, Mateo J, Soria JM, Oliver A, Martinez-Sanchez E, Vallve C, Borrell M, Urrutia T, Fontcuberta J: The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism. Thromb Haemost 2005, 93: 468-474.PubMed
53.
Ohira T, Cushman M, Tsai MY, Zhang Y, Heckbert SR, Zakai NA, Rosamond WD, Folsom AR: ABO blood group, other risk factors and incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE). J Thromb Haemost 2007, 5: 1455-1461. 10.1111/j.1538-7836.2007.02579.xCrossRefPubMed
Metadata
Title
Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications
Authors
Massimo Franchini
Franco Capra
Giovanni Targher
Martina Montagnana
Giuseppe Lippi
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Thrombosis Journal / Issue 1/2007
Electronic ISSN: 1477-9560
DOI
https://doi.org/10.1186/1477-9560-5-14

Other articles of this Issue 1/2007

Thrombosis Journal 1/2007 Go to the issue

Original clinical investigation

Evaluation of the TEG® platelet mapping™ assay in blood donors

Original basic research

Histological composition and progression of carotid plaque

Editorial

Antithrombotic prevention in vascular disease: bases for a new strategy in antithrombotic therapy

Case report

Percutaneous mechanical thrombectomy for the treatment of acute massive pulmonary embolism: case report

Review

Clopidogrel in Orthopaedic patients: a review of current practice in Scotland

Original clinical investigation

Hyperhomocysteinemia in women with unexplained sterility or recurrent early pregnancy loss from Southern Italy: a preliminary report
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits