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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2011

Open Access 01-12-2011 | Research

Family association study between INSR gene polymorphisms and PCOS in Han Chinese

Authors: Xinghua Xu, Han Zhao, Yuhua Shi, Li You, Yuehong Bian, Yueran Zhao, Zi-Jiang Chen

Published in: Reproductive Biology and Endocrinology | Issue 1/2011

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Abstract

Background

Polycystic ovary syndrome (PCOS) is a complex disease having both genetic and environmental components. Candidate genes with insulin metabolism have been hypothesized to be involved in the etiology of this syndrome. In the present study, we investigated the genetic association between polymorphisms in the insulin receptor (INSR) gene and PCOS.

Methods

A total of 260 family trios were recruited and performed a family-based analysis to assess linkage and association between four single nucleotide polymorphisms (SNPs) (rs1799817, rs2059807, rs8108622 and rs10500204) of INSR gene and PCOS.

Results

Using the transmission disequilibrium test (TDT), we failed to find that rs1799817 (p = 0.486), rs2059807 (p = 0.195), rs8108622 (p = 0.866) and rs10500204 (p = 1.0) were significantly overtransmitted to PCOS offspring from their parents.

Conclusion

No significant evidence of association or linkage was found in the four tested markers, indicating that our family samples did not support susceptibility of the INSR gene to PCOS.
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Metadata
Title
Family association study between INSR gene polymorphisms and PCOS in Han Chinese
Authors
Xinghua Xu
Han Zhao
Yuhua Shi
Li You
Yuehong Bian
Yueran Zhao
Zi-Jiang Chen
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2011
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-9-76

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