Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2011

Open Access 01-12-2011 | Research

Is interleukin-18 associated with polycystic ovary syndrome?

Authors: Yan Yang, Jie Qiao, Rong Li, Mei-Zhi Li

Published in: Reproductive Biology and Endocrinology | Issue 1/2011

Login to get access

Abstract

Background

Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation.

Methods

To investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin resistance (IR). Sixty consecutive women with PCOS and thirty controls were recruited. Serum level of IL-18 and fasting blood glucose, fasting insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were measured.

Results

Serum levels of IL-18 was significantly higher in the PCOS group than in the control group. Serum level of IL-18 was higher in the PCOS group with IR than in the PCOS group without IR. Serum level of IL-18 was higher in obese PCOS patients than in lean PCOS patients. Serum level of IL-18 was higher in lean PCOS patients than in the lean control group. Serum level of IL-18 in the PCOS group was positively related to BMI, IR index and T.

Conclusion

IL-18 level was increased in PCOS patients, and correlated with insulin resistance, obesity and hyperandrogenism.
Appendix
Available only for authorised users
Literature
1.
Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF: A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab. 2000, 85: 2434-2438. 10.1210/jc.85.7.2434.PubMed
2.
Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R: Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998, 83: 3078-3082. 10.1210/jc.83.9.3078.PubMed
3.
Dunaif A: Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev. 1997, 18: 774-800. 10.1210/er.18.6.774.PubMed
4.
Legro RS, Kunselman AR, Dodson WC, Dunaif A: Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab. 1999, 84: 165-169. 10.1210/jc.84.1.165.PubMed
5.
Conn JJ, Jacobs HS, Conway GS: The prevalence of polycystic ovaries in women with type 2 diabetes mellitus. Clin Endocrinol. 2000, 52: 81-86. 10.1046/j.1365-2265.2000.00884.x.CrossRef
6.
Nestler JE, Clore JN, Blackard WG: The central role of obesity (hyperinsulinemia) in the pathogenesis of the polycystic ovary syndrome. Am J Obstet Gynecol. 1989, 161: 1095-1097.CrossRefPubMed
7.
Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N: Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab. 2001, 86: 2453-2455. 10.1210/jc.86.6.2453.CrossRefPubMed
8.
Amato G, Conte M, Mazziotti G, Lalli E, Vitolo G, Tucker AT, Bellastella A, Carella C, Izzo A: Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles. Obstet Gynecol. 2003, 101: 1177-82. 10.1016/S0029-7844(03)00233-3.CrossRefPubMed
9.
Okamura H, Tsutsui H, Kashiwamura S, Yoshimoto T, Nakanishi K: Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv Immunol. 1998, 70: 281-312. full_text.CrossRefPubMed
10.
Stephens JM, Butts MD, Pekala PH: Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumour necrosis factor-a. J Mol Endocrinol. 1992, 9: 61-72. 10.1677/jme.0.0090061.CrossRefPubMed
11.
Heinrich PC, Castell JV, Andus T: Interleukin-6 and the acute phase response. Biochem J. 1990, 265: 621-636.CrossRefPubMed
12.
Blankenberg S, Tiret L, Bickel C, Peetz D, Cambien F, Meyer J, Rupprecht HJ: Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina. Circulation. 2002, 106: 24-30. 10.1161/01.CIR.0000020546.30940.92.CrossRefPubMed
13.
Hart R, Hickey M, Franks S: Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2004, 18: 671-683. 10.1016/j.bpobgyn.2004.05.001.CrossRefPubMed
14.
The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004, 81: 19-25.
15.
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome(PCOS). Hum Reprod. 2004, 19: 41-47. 10.1093/humrep/deh098.CrossRef
16.
Xing XY, Yang WY, Yang ZJ: The diagnostic significance of homeostasis model assessment of insulin resistance in metabolic syndrome among subjects with different glucose tolerance. Chin J Diabetes. 2004, 2: 182-6.
17.
Tai ES, Lim SC, Chew SK, Tan BY, Tan CE: Homeostasis model assessment in a population with mixed ethnicity: the 1992 Singapore National Health Survey. Diabetes Res Clin Pract. 2000, 49: 159-68. 10.1016/S0168-8227(00)00152-2.CrossRefPubMed
18.
Kanazawa M, Yoshiike N, Osaka T, Numba Y, Zimmet P, Inoue S: Criteria and classification of obesity in Japan and Asia-Oceania. Asia Pac J Clin Nutr. 2002, 11 (Suppl): 732-737. 10.1046/j.1440-6047.11.s8.19.x.CrossRef
19.
El-Mezzein RE: Matsumoto mononuclear cells of patients with bronchial asthma and atopic dermatitis. Clin Exp Immunol. 2001, 126: 193-198. 10.1046/j.1365-2249.2001.01664.x.CrossRefPubMed
20.
Higashi N, Gesser B, Kawana S: Thestrup-Pedersen K. Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic dermatitis. J Allergy Clin Immunol. 2001, 108: 607-614. 10.1067/mai.2001.118601.CrossRefPubMed
21.
Escobar-Morreale HF, Botella-Carretero JI, Villuendas G, Sancho J, San Millan JL: Serum Interleukin-18 Concentrations Are Increased in the Polycystic Ovary Syndrome: Relationship to Insulin Resistance and to Obesity. J Clin Endocrinol Metab. 2004, 89: 806-811. 10.1210/jc.2003-031365.CrossRefPubMed
22.
Huang X, Huang H, Dong M, Yao Q, Wang H: Serum and placental interleukin-18 are elevated in preeclampsia. J Reprod Immunol. 2005, 65: 77-87. 10.1016/j.jri.2004.09.003.CrossRefPubMed
23.
Ida A, Tsuji Y, Muranaka J, Kanazawa R, Nakata Y, Adachi S, Okamura H, Koyama K: IL-18 in preganacy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies. J Reprod Immunol. 2000, 47: 65-74. 10.1016/S0165-0378(00)00058-9.CrossRefPubMed
24.
Mallat Z, Corbaz A, Scoazec A, Besnard S, Leseche G, Chvatchko Y, Tedgui A: Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability. Circulation. 2001, 104: 1598-1603. 10.1161/hc3901.096721.CrossRefPubMed
25.
Kawasaki D, Tsujino T, Morimoto S, Fujioka Y, Naito Y, Okumura T, Masutani M, Shimizu H, Yuba M, Ueda A, Ohyanagi M, Kashiwamura S, Okamura H, Iwasaki T: Usefulness of circulating interleukin-18 concentration in acute myocardial infarction as a risk factor for late restenosis after emergency coronary angioplasty. Am J Cardiol. 2003, 91: 1258-1261. 10.1016/S0002-9149(03)00279-0.CrossRefPubMed
26.
Esposito K, Pontillo A, Ciotola M, Di Palo C, Grella E, Nicoletti G, Giugliano D: Weight loss reduces interleukin-18 levels in obese women. J Clin Endocrinol Metab. 2002, 87: 3864-3866. 10.1210/jc.87.8.3864.CrossRefPubMed
27.
Legro RS: Polycystic ovary syndrome and cardiovascular disease: a premature association?. Endocr Rev. 2003, 24: 302-312. 10.1210/er.2003-0004.CrossRefPubMed
28.
Solomon CG: The epidemiology of polycystic ovary syndrome. Prevalence and associated disease risks. Endocrinol Metab Clin North Am. 1999, 28: 247-263. 10.1016/S0889-8529(05)70069-4.CrossRefPubMed
29.
Christian RC, Dumesic DA, Behrenbeck T, Oberg AL, Sheedy PF, Fitzpatrick LA: Prevalence and predictors of coronary artery calcification in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003, 88: 2562-2568. 10.1210/jc.2003-030334.CrossRefPubMed
30.
Talbott EO, Guzick DS, Sutton-Tyrrell K, McHugh-Pemu KP, Zborowski JV, Remsberg KE, Kuller LH: Evidence for association between polycystic ovary syndrome and premature carotid atherosclerosis in middle-aged women. Arteriosclerosis Thromb Vasc Biol. 2000, 20: 2414-2421.CrossRef
31.
Lakhani K, Seifalian AM, Hardiman P: Impaired carotid viscoelastic properties in women with polycystic ovaries. Circulation. 2002, 106: 81-85. 10.1161/01.CIR.0000020681.19400.8A.CrossRefPubMed
Metadata
Title
Is interleukin-18 associated with polycystic ovary syndrome?
Authors
Yan Yang
Jie Qiao
Rong Li
Mei-Zhi Li
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2011
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-9-7

Other articles of this Issue 1/2011

Reproductive Biology and Endocrinology 1/2011 Go to the issue

Research

Examination of relaxin and its receptors expression in pig gametes and embryos

Methodology

In vivo monitoring of fetoplacental Vegfr2 gene activity in a murine pregnancy model using a Vegfr2-luc reporter gene and bioluminescent imaging

Methodology

Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure

Review

Aromatase inhibitors in men: effects and therapeutic options

Research

Site-specific endometrial injury improves implantation and pregnancy in patients with repeated implantation failures

Research

The spatiotemporal expression of multiple coho salmon ovarian connexin genes and their hormonal regulation in vitro during oogenesis