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Open Access 01-12-2011 | Methodology

Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli

Authors: Munehiro Yuhki, Takashi Kajitani, Takakazu Mizuno, Yuko Aoki, Tetsuo Maruyama

Published in: Reproductive Biology and Endocrinology | Issue 1/2011

Abstract

Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phenotype to primary endometrial stromal cells. KC02-44D would be useful for studies of human endometrial function and its associated pathologies.

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Title: Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli
Authors: Munehiro Yuhki
Takashi Kajitani
Takakazu Mizuno
Yuko Aoki
Tetsuo Maruyama
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2011
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/1477-7827-9-104

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Springer Medicine

Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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