Published in:
Open Access
01-12-2008 | Research
The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome
Authors:
Ahlam Al-Ghamdi, Serdar Coskun, Saad Al-Hassan, Rafat Al-Rejjal, Khalid Awartani
Published in:
Reproductive Biology and Endocrinology
|
Issue 1/2008
Login to get access
Abstract
Background
To evaluate the relationship between endometrial thickness on day of human chorionic gonadotrophin administration (hCG) and pregnancy outcome in a large number of consecutive in vitro fertilization and embryo transfer (IVF-ET) cycles.
Methods
A retrospective cohort study including all patients who had IVF-ET from January 2003–December 2005 conducted at a tertiary center.
Results
A total of 2464 cycles were analysed. Pregnancy rate (PR) was 35.8%. PR increased linearly (r = 0.864) from 29.4% among patients with a lining of less than or equal to 6 mm, to 44.4% among patients with a lining of greater than or equal to 17 mm. ROC showed that endometrial thickness is not a good predictor of PR, so a definite cut-off value could not be established (AUC = 0.55).
Conclusion
There is a positive linear relationship between the endometrial thickness measured on the day of hCG injection and PR, and is independent of other variables. Hence aiming for a thicker endometrium should be considered.