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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2004

Open Access 01-12-2004 | Review

Trophoblast-uterine interactions at implantation

Authors: John D Aplin, Susan J Kimber

Published in: Reproductive Biology and Endocrinology | Issue 1/2004

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Abstract

Implantation of the embryo in the uterus is a critical and complex event and its failure is widely considered an impediment to improved success in assisted reproduction. Depending on whether placentation is invasive or superficial (epitheliochorial), the embryo may interact transiently or undergo a prolonged adhesive interaction with the uterine epithelium. Numerous candidate interactions have been identified, and there is good progress on identifying gene networks required for early placentation. However no molecular mechanisms for the epithelial phase are yet firmly established in any species. It is noteworthy that gene ablation in mice has so far failed to identify obligatory initial molecular events.
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Metadata
Title
Trophoblast-uterine interactions at implantation
Authors
John D Aplin
Susan J Kimber
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2004
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-2-48

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