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Health and Quality of Life Outcomes

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Open Access 01-12-2007 | Research

Validation of two generic patient-reported outcome measures in patients with type 2 diabetes

Authors: Louis S Matza, Kristina S Boye, Nicole Yurgin

Published in: Health and Quality of Life Outcomes | Issue 1/2007

Abstract

Background

Prior to using a generic patient-reported outcome measure (PRO), the measure should be validated within the target population. The purpose of the current study was to validate two generic measures in patients with type 2 diabetes.

Methods

Patients with type 2 diabetes in Scotland and England completed two generic measures: EQ-5D and Psychological General Well-Being Index (PGWB). Two diabetes-specific measures were administered: ADS and DSC-R. Analyses assessed reliability and validity.

Results

There were 130 participants (53 Scotland; 77 England; 64% male; mean age = 55.7 years). Responses on the EQ-5D and PGWB reflected moderate impairment consistent with previous diabetes samples: mean EQ-5D Index score, 0.75; EQ-5D VAS, 68.8; PGWB global score, 67.9. All scales of the PGWB demonstrated good internal consistency reliability (Cronbach's alpha = 0.77 to 0.97). The EQ-5D and PGWB demonstrated convergent validity through significant correlations with the ADS (r = 0.48 to 0.61), DSC-R scales (r = 0.33 to 0.81 except ophthalmology subscale), and Body Mass Index (r = 0.15 to 0.38). The EQ-5D and PGWB discriminated between groups of patients known to differ in diabetes-related characteristics (e.g., history of hypoglycemia).

Conclusion

Results support the use of the EQ-5D and PGWB among patients with type 2 diabetes, possibly in combination with condition-specific measures.

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Title: Validation of two generic patient-reported outcome measures in patients with type 2 diabetes
Authors: Louis S Matza
Kristina S Boye
Nicole Yurgin
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Health and Quality of Life Outcomes / Issue 1/2007
Electronic ISSN: 1477-7525
DOI: https://doi.org/10.1186/1477-7525-5-47

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Validation of two generic patient-reported outcome measures in patients with type 2 diabetes

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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