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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2003

Open Access 01-12-2003 | Research

Health related quality of life in 3 and 4 year old children and their parents: preliminary findings about a new questionnaire

Authors: Anne F Klassen, Jeanne M Landgraf, Shoo K Lee, Morris Barer, Parminder Raina, Herbert WP Chan, Derek Matthew, David Brabyn

Published in: Health and Quality of Life Outcomes | Issue 1/2003

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Abstract

Background

Few measures of health related quality of life exist for use with preschool aged children. The objective of this study was to assess reliability and validity of a new multidimensional generic measure of health-related quality of life developed for use with preschool children.

Methods

Cross-sectional survey sent to parents as their child turned 3 1/2 years of age. The setting was the province of British Columbia, Canada. Patients included all babies admitted to tertiary level neonatal intensive care units (NICU) at birth over a 16-month period, and a consecutive sample of healthy babies. The main outcome measure was a new full-length questionnaire consisting of 3 global items and 10 multi-item scales constructed to measure the physical and emotional well-being of toddlers and their families.

Results

The response rate was 67.9%. 91% (NICU) and 84% (healthy baby) of items correlated with their own domain above the recommended standard (0.40). 97% (NICU) and 87% (healthy baby) of items correlated more highly (≥ 2 S.E.) with their hypothesized scale than with other scales. Cronbach's alpha coefficients varied between .80 and .96. Intra-class correlation coefficients were above .70. Correlations between scales in the new measure and other instruments were moderate to large, and were stronger than between non-related domains. Statistically significant differences in scale scores were observed between the NICU and healthy baby samples, as well as between those diagnosed with a health problem requiring medical attention in the past year versus those with no health problems.

Conclusions

Preliminary results indicate the new measure demonstrates acceptable reliability and construct validity in a sample of children requiring NICU care and a sample of healthy children. However, further development work is warranted.
Literature
1.
2.
Varni JW, Seid M, Kurtin PS: PedsQL 4.0: reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care 2001, 39: 800–812. 10.1097/00005650-200108000-00006PubMedCrossRef
3.
Eiser C, Mohay H, Morse R: The measurement of quality of life in young children. Child Care Health Dev 2000, 26: 401–414. 10.1046/j.1365-2214.2000.00154.xPubMedCrossRef
4.
Eiser C, Morse R: Can parents rate their child's health-related quality of life? Results of a systematic review. Qual Life Res 2001, 10: 347–357. 10.1023/A:1012253723272PubMedCrossRef
5.
Schmidt LJ, Garratt AM, Fitzpatrick R: Child/parent-assessed population health outcome measures: a structured review. Child Care Health Dev 2002, 28: 227–237. 10.1046/j.1365-2214.2002.00266.xPubMedCrossRef
6.
Connolly MA, Johnson JA: Measuring Quality of life in Paediatric Patients. Pharmacoeconomics 1999, 16: 605–625.PubMedCrossRef
7.
Pal DK: Quality of life assessment in children: a review of conceptual and methodological issues in multidimensional health status measures. J Epidemiol Community Health 1996, 50: 391–396.PubMedCentralPubMedCrossRef
8.
Spieth LE, Harris CV: Assessment of health-related quality of life in children and adolescents: an integrative review. J Pediatr Psych 1996, 21: 175–193.CrossRef
9.
Abetz L: The Infant/toddler Quality of Life Questionnaire: Conceptual framework, logic, content, and preliminary psychometric results Final Report to Schering-Plough Laboratories and Health Technology Associates. New England Medical Center 1994.
10.
Langraf JM, Abetz L, Ware JE: The Child Health Questionnaire (CHQ): A User's Manual 2nd Printing Boston MA: HealthAct 1999.
11.
World Health Organization: Constitution of the World Health Organization. WHO Basic Documents Geneva 1948.
12.
Caplan F: The first twelve months of life: your baby's growth month by months Toronto, Canada: Bantam Books 1975.
13.
Fekkes M, Theunissen NCM, Brugman E, Veen S, Verrips EGH, Koopman HM, Vogels T, Wit JM, Verloove-Vanhorick SP: Development and psychometric evaluation of the TAPQOL: a health-related quality of life instrument for 1–5-year-old children. Qual Life Res 2000, 9: 961–972. 10.1023/A:1008981603178PubMedCrossRef
14.
Veen S, Feekes M, Koopman HM, Zwinderman KA, Brugman E, Wit JM: Quality of life in preschool children born preterm. Dev Med Child Neurol 2001, 43: 460–465.PubMedCrossRef
15.
Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJ: Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA 2002, 288: 728–737. 10.1001/jama.288.6.728PubMedCrossRef
16.
Lorenz JM, Wooliever DE, Jetton JR, Paneth N: A quantitative review of mortality and developmental disability in extremely premature newborns. Arch Pediatr Adolesc Med 1998, 152: 425–435.PubMedCrossRef
17.
Escobar GJ, Littenberg B, Petitti DB: Outcome among surviving very low birthweight infants: a meta-analysis. Archives of Disease in Childhood 1991, 66: 204–211.PubMedCentralPubMedCrossRef
18.
Aylward GP, Pfeiffer SI, Wright A, Verhulst SJ: Outcome studies of low birth weight infants published in the last decade: A metaanalysis. The Journal of Pediatrics 1989, 115: 515–520.PubMedCrossRef
19.
Saigal S: Perception of health status and quality of life of extremely low-birth weight survivors. The consumer, the provider, and the child. Clin Perinatol 2000, 27: 403–419.PubMedCrossRef
20.
Hack M, Flannery DJ, Schluchter M, Cartar L, Borawski E, Klein N: Outcomes in young adulthood for very-low-birth-weight infants. NEJM 2002, 346: 149–157. 10.1056/NEJMoa010856PubMedCrossRef
21.
Victorian Infant Collaborative Study Group: Improved outcome into the 1990s for infants weighing 500–999 g at birth. The Victorian Infant Collaborative Study Group. Arch Dis Child Fetal Neonatal Ed 1997, 77: F91–94.CrossRef
22.
Wolke D, Meyer R: Cognitive status, language attainment and prereading skills of 6-year-old very preterm children and their peers: the Bavarian Longitudinal Study. Dev Med Child Neurol 1999, 41: 94–109. 10.1017/S0012162299000201PubMedCrossRef
23.
Vohr BR, Wright LL, Dusick AM, Mele L, Verter J, Steichen JJ, Simon NP, Wilson DC, Broyles S, Bauer CR, Delaney-Black V, Yolton KA, Fleisher BE, Papile LA, Kaplan MD: Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993–4. Pediatrics 2000, 105: 1216–26.PubMedCrossRef
24.
Walther FJ, den Ouden AL, Verloove-Vanhorick SP: Looking back in time: outcome of a national cohort of very preterm infants born in The Netherlands in 1983. Early Hum Dev 2000, 59: 175–91. 10.1016/S0378-3782(00)00094-3PubMedCrossRef
25.
Grunau RE, Whitfield MF, Davis C: Pattern of learning disabilities in children with extremely low birth weight and broadly average intelligence. Arch Pediatr Adolesc Med 2002, 156: 615–20.PubMedCrossRef
26.
Siagal S, Stoskopf BL, Streiner DL, Burrow E: Physical growth and current health status of infants who were of extremely low birth weight and controls as adolescence. Pediatrics 2001, 108: 407–415.CrossRef
27.
Stjernqvist K, Svenningsen NW: Ten-year follow-up of children born before 29 gestational weeks: health, cognitive development, behaviour and school achievement. Acta Paediatr 1999, 88: 557–62. 10.1080/08035259950169594PubMedCrossRef
28.
Klassen AF, Lee SK, Raina P, Chan WPH, Matthew D, Brabyn D: Health status and health related quality of life in a population-based sample of NICU graduates. Pediatrics, in press.
29.
Klassen AF, Lee SK, Raina P, Chan H, Matthew D, Brabyn D: Reliability and validity of the Infant Toddler Quality of Life Questionnaire. Qual Life Res 2002, 11: 684.
30.
Ware JE, Harris WJ, Gandek B, Rogers BW, Reese PR: MAP-R for Windows Version 1.1 Boston, MA: Health Assessment Lab 1997.
31.
Ware JE Jr, Gandek B for the IQOLA Project Group: Methods of testing data quality, scaling assumptions, and reliability: The IQOLA Project Approach. International Quality of Life Assessment. J Clin Epidemiol 1998, 51: 945–952.PubMed
32.
Hayashi T, Hays RD: A microcomputer program for analyzing multi-trait-multimethod matrices. Beh Res Meth Instr Comp 1987, 19: 345–348.CrossRef
33.
Campbell DT, Fiske DW: Convergent and discriminant validation by the multitrait-multimethod matrix. Psychological Bulletin 1959, 56: 85–105.CrossRef
34.
Howard KI, Forehand GC: A method for correcting item-total correlations for the effect of relevant item inclusion. Educational and Psychological Measurement 1962, 22: 731–735.CrossRef
35.
Helmstadter GC: Principles of psychological measurement New York: Appleton-Centry Crofts Inc 1964.
36.
Nunnally JC, Bernstein IH: Psychometric Theory 3 Edition New York: McGraw-Hill 1994.
37.
Streiner DL, Norman GR: Health Measurement Scales. A Practical Guide to their Development and Use 2 Edition Oxford, England: Oxford University Press 1995, 64–65.
38.
Fayers PM, Machin D: Quality of Life Assessment, Analysis and Interpretation Chichester, England: John Wiley & Sons, Ltd 2000, 149–50.
39.
Achenbach TM, Rescorla LA: Manual for the ASEBA Preschool Forms and Profiles Burlington, VT: University of Vermont Department of Psychiatry 2000.
40.
Ware JE, Snow KK, Kosinski M: SF-36 Health Survey: Manual and Interpretation Guide Lincoln, RI: QualityMetric Incorporated 2000.
41.
Ware JE, Kosinski M: SF-36 Physical & Mental Health Summary Scales: A Manual for Users of Version 1 2 Edition Lincoln, RI: QualityMetric 2001.
42.
Cadman D, Rosenbaum P, Boyle M, Offord DR: Children with chronic illness: family and parent demographic characteristics and psychosocial adjustment. Pediatrics 1991, 87: 884–9.PubMed
43.
Juniper EF, Guyatt GH, Jaeschke R: How to develop and validate a new health-related quality of life instrument. In B Quality of life and pharmacoeconomics in clinical trials 2 Edition (Edited by: Spilker B). Philadelphia: Lippincott-Rave 1996, 49–56.
44.
Edwards P, Roberts I, Clarke M, DiGuiseppi C, Pratap S, Wentz R, Kwan I: Increasing response rates to postal questionnaires: systematic review. BMJ 2002, 324: 1183–1192. 10.1136/bmj.324.7347.1183PubMedCentralPubMedCrossRef
45.
Asch DA, Jedrziewski MK, Christakis NA: Response rates to mail surveys published in medical journals. J Clin Epidemiol 1997, 50: 1129–1136. 10.1016/S0895-4356(97)00126-1PubMedCrossRef
Metadata
Title
Health related quality of life in 3 and 4 year old children and their parents: preliminary findings about a new questionnaire
Authors
Anne F Klassen
Jeanne M Landgraf
Shoo K Lee
Morris Barer
Parminder Raina
Herbert WP Chan
Derek Matthew
David Brabyn
Publication date
01-12-2003
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2003
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-1-81

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