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Clinical and Molecular Allergy

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Open Access 01-12-2007 | Research

Systemic and local eosinophil inflammation during the birch pollen season in allergic patients with predominant rhinitis or asthma

Authors: Mary Kämpe, Gunnemar Stålenheim, Christer Janson, Ingrid Stolt, Marie Carlson

Published in: Clinical and Molecular Allergy | Issue 1/2007

Abstract

Background

The aim of the study was to investigate inflammation during the birch pollen season in patients with rhinitis or asthma.

Methods

Subjects with birch pollen asthma (n = 7) or rhinitis (n = 9) and controls (n = 5) were studied before and during pollen seasons. Eosinophils (Eos), eosinophil cationic protein (ECP) and human neutrophil lipocalin were analysed.

Results

Allergic asthmatics had a larger decline in FEV1 after inhaling hypertonic saline than patients with rhinitis (median) (-7.0 vs.-0.4%, p = 0.02). The asthmatics had a lower sesonal PEFR than the rhinitis group. The seasonal increase in B-Eos was higher among patients with asthma (+0.17 × 109/L) and rhinitis (+0.27 × 109/L) than among controls (+0.01 × 109/L, p = 0.01). Allergic asthmatics and patients with rhinitis had a larger increase in sputum ECP (+2180 and +310 μg/L) than the controls (-146 μg/L, p = 0.02). No significant differences in inflammatory parameters were found between the two groups of allergic patients.

Conclusion

Patients with allergic asthma and rhinitis have the same degree of eosinophil inflammation. Despite this, only the asthmatic group experienced an impairment in lung function during the pollen season.

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Title: Systemic and local eosinophil inflammation during the birch pollen season in allergic patients with predominant rhinitis or asthma
Authors: Mary Kämpe
Gunnemar Stålenheim
Christer Janson
Ingrid Stolt
Marie Carlson
Publication date: 01-12-2007
Publisher: BioMed Central
Published in: Clinical and Molecular Allergy / Issue 1/2007
Electronic ISSN: 1476-7961
DOI: https://doi.org/10.1186/1476-7961-5-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Systemic and local eosinophil inflammation during the birch pollen season in allergic patients with predominant rhinitis or asthma

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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