Published in:
Open Access
01-12-2008 | Research
An integrative model for recurrence in ovarian cancer
Authors:
Alexandros Laios, Sharon A O'Toole, Richard Flavin, Cara Martin, Martina Ring, Noreen Gleeson, Tom D'Arcy, Eamonn PJ McGuinness, Orla Sheils, Brian L Sheppard, John J O' Leary
Published in:
Molecular Cancer
|
Issue 1/2008
Login to get access
Excerpt
Ovarian cancer is one of the commonest cancers in women and the leading cause of death from gynaecological malignancy in the western world. About 205,000 cases of ovarian cancer are diagnosed worldwide each year [
1]. It accounts for 3% of female cancers in Ireland with over 350 new cases each year [
2]. Marked heterogeneity is a hallmark of the disease, not only in tumor histotype and grade but also in response to chemotherapy and overall prognosis [
3]. Over 90% of cases arise from the surface epithelium. Serous adenocarcinomas are the commonest and account for 40%–50% of malignant neoplasms [
4]. …