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Molecular Cancer
Published in: Molecular Cancer 1/2011

Open Access 01-12-2011 | Review

Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma

Authors: Reason Wilken, Mysore S Veena, Marilene B Wang, Eri S Srivatsan

Published in: Molecular Cancer | Issue 1/2011

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Abstract

Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. More recently curcumin has been found to possess anti-cancer activities via its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cycle regulation, apoptosis, tumorigenesis and metastasis. Curcumin has shown anti-proliferative effect in multiple cancers, and is an inhibitor of the transcription factor NF-κB and downstream gene products (including c-myc, Bcl-2, COX-2, NOS, Cyclin D1, TNF-α, interleukins and MMP-9). In addition, curcumin affects a variety of growth factor receptors and cell adhesion molecules involved in tumor growth, angiogenesis and metastasis. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and treatment protocols include disfiguring surgery, platinum-based chemotherapy and radiation, all of which may result in tremendous patient morbidity. As a result, there is significant interest in developing adjuvant chemotherapies to augment currently available treatment protocols, which may allow decreased side effects and toxicity without compromising therapeutic efficacy. Curcumin is one such potential candidate, and this review presents an overview of the current in vitro and in vivo data supporting its therapeutic activity in head and neck cancer as well as some of the challenges concerning its development as an adjuvant chemotherapeutic agent.
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Literature
1.
Stell PM: Survival time in end-stage head and neck cancer. Eur J Surgical Oncol. 1989, 15: 407-410.
2.
Vokes EE, Weichselbaum RR, Lippman SM, Hong WK: Head and neck cancer. N Engl J Med. 1993, 328: 184-194. 10.1056/NEJM199301213280306PubMedCrossRef
3.
Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, Ruhl J, Howlader N, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Cronin K, Chen HS, Feuer EJ, Stinchcomb DG, Edwards BK: SEER Cancer Statistics Review 1975-2007. National Cancer Institute. Bethesda, MD.
4.
Syrjänen S: The role of human papillomavirus infection in head and neck cancers. Ann Oncol. 2010, Suppl 7: vii243-vii245.
5.
Posner MR: Integrating systemic agents into multimodality treatment of locally advanced head and neck cancer. Ann Oncol. 2010, Suppl 7: vii246-vii251. 10.1093/annonc/mdq291. 10.1093/annonc/mdq291
6.
Wong SJ, Harari PM, Garden AS, Schwartz M, Bellm L, Chen A, Curran WJ, Murphy BA, Ang KK: Longitudinal oncology registry of head and neck carcinoma (LORHAN): analysis of chemoradiation treatment approaches in the United States. Cancer. 2010
7.
Yip H, Chopra R, Chakrabarti R, Veena MS, Ramamurthy B, Srivatsan ES, Wang MB: Cisplatin-induced growth arrest of head and neck cancer correlates with increased expression of p16 and p53. Arch Otolaryngology Head and Neck Surgery. 2006, 132: 317-326. 10.1001/archotol.132.3.317. 10.1001/archotol.132.3.317CrossRef
8.
Cohen EE, Lingen MW, Vokes EE: The expanding role of systemic therapy in head and neck cancer. J Clin Oncol. 2004, 22: 1743-1752. 10.1200/JCO.2004.06.147PubMedCrossRef
9.
Chandana SR, Conley BA: Neoadjuvant chemotherapy for locally advanced squamous cancers of the head and neck: current status and future prospects. Curr Opin Oncol. 2009, 21: 218-223. 10.1097/CCO.0b013e328329abe5PubMedCrossRef
10.
Adelstein DJ, Moon J, Hanna E, Giri PG, Mills GM, Wolf GT, Urba SG: Docetaxel, cisplatin, and fluorouracil induction chemotherapy followed by accelerated fractionation/concomitant boost radiation and concurrent cisplatin in patients with advanced squamous cell head and neck cancer: A Southwest Oncology Group phase II trial (S0216). Head Neck. 2010, 32: 221-228.PubMedCentralPubMed
11.
Vissink A, Jansma J, Spigkervet FKL, Spijkervet FK, Burlage FR, Coppes RP: Oral sequelae of head and neck radiotherapy. Crit Rev Oral Biol Med. 2003, 14: 199-212. 10.1177/154411130301400305PubMedCrossRef
12.
Thorn JJ, Hansen HS, Spetch L, Bastholt L: Osteoradionecrosis of the jaws: clinical characteristics and relation to field of irradiation. J Oral Maxillofac Surg. 2000, 58: 1088-1093. 10.1053/joms.2000.9562PubMedCrossRef
13.
Argiris A, Brockstein BE, Haraf DJ, Stenson KM, Mittal BB, Kies MS, Rosen FR, Jovanovic B, Vokes EE: Competing causes of death and second primary tumors in patients with locoregionally advanced head and neck cancer treated with chemoradiotherapy. Clin Cancer Res. 2004, 10: 1956-1962. 10.1158/1078-0432.CCR-03-1077PubMedCrossRef
14.
Bonner JA, Harai PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK: Radiotherapy plus cetuximab for squamous cell carcinoma of the head and neck. N Eng J Med. 2006, 354: 567-578. 10.1056/NEJMoa053422. 10.1056/NEJMoa053422CrossRef
15.
Bonner JA, Harai PM, Giralt J, Cohen RB, Jones CU, Sur RK, Raben D, Baselga J, Spencer SA, Zhu J, Youssoufian H, Rowinsky EK, Ang KK: Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5 year survival data from a phase 3 randomised trial and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010, 11: 21-8. 10.1016/S1470-2045(09)70311-0PubMedCrossRef
16.
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, Peyrade F, Benasso M, Vynnychenko I, De Raucourt D, Bokemeyer C, Schueler A, Amellal N, Hitt R: Platinum based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008, 359: 1116-1127. 10.1056/NEJMoa0802656PubMedCrossRef
17.
Vermorken JB, Herbst RS, Leon X, Amellal N, Baselga J: Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies. Cancer. 2008, 112: 2710-2719. 10.1002/cncr.23442PubMedCrossRef
18.
Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK: Turmeric and curcuminBiological actions and medicinal applications. Curr Sci. 2004, 87: 44-50.
19.
Jurenka JS: Anti-inflammatory properties of curcumin, a major constituent of Curcima longa: A review of preclinical and clinical research. Altern Med Rev. 2009, 14: 141-153.PubMed
20.
Aggarwal BB, Sundaram C, Malani N, Ichikawa H: Curcumin: The Indian solid gold. Adv Exp Med Biol. 2007, 595: 1-75. full_textPubMedCrossRef
21.
22.
Aggarwal BB, Kumar A, Bharti AC: Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003, 23: 363-398.PubMed
23.
Sreejayan Rao MN: Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol. 1994, 46: 1013-1016.PubMedCrossRef
24.
Masuda T, Maekawa T, Hidaka K, Bando H, Takeda Y, Yamaguchi H: Chemical studies on antioxidant mechanisms of curcumin: analysis of oxidative coupling products from curcumin and linoleate. J Agric Food Chem. 2001, 49: 2539-2547. 10.1021/jf001442xPubMedCrossRef
25.
Joe B, Vijaykumar M, Lokesh BR: Biological properties of curcumin--cellular and molecular mechanisms of action. Crit Rev Food Sci Nut. 2004, 44: 97-111. 10.1080/10408690490424702. 10.1080/10408690490424702CrossRef
26.
Joe B, Lokesh BR: Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochem Biophys Acta. 1994, 1224: 255-263. 10.1016/0167-4889(94)90198-8PubMedCrossRef
27.
Brouet I, Ohshima H: Curcumin, an anti-tumour and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun. 1995, 206: 533-540. 10.1006/bbrc.1995.1076PubMedCrossRef
28.
Chan MM, Huang HI, Fenton MR, Fong D: In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem Pharmacol. 1998, 55: 1955-1962. 10.1016/S0006-2952(98)00114-2PubMedCrossRef
29.
Jung KK, Lee HS, Cho JY, Shin WC, Rhee MH, Kim TG, Kang JH, Kim SH, Hong S, Kang SY: Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci. 2006, 79: 2022-2031. 10.1016/j.lfs.2006.06.048PubMedCrossRef
30.
Ray B, Lahiri DK: Neuroinflammation in Alzheimer's Disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009, 4: 434-444. 10.1016/j.coph.2009.06.012. 10.1016/j.coph.2009.06.012CrossRef
31.
He LF, Chen HJ, Qian LH: Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain Res. 2010, 1339: 60-69. 10.1016/j.brainres.2010.04.014PubMedCrossRef
32.
Chan MM: Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochem Pharmacol. 1995, 49: 1551-1556. 10.1016/0006-2952(95)00171-UPubMedCrossRef
33.
Singh S, Aggarwal BB: Activation of transcription factor NF-kB is suppressed by curcumin (diferuloylmethane). J Biol Chem. 1995, 270: 24995-25000. 10.1074/jbc.270.25.14867PubMedCrossRef
34.
Brennan P, O'Neill LA: Inhibition of nuclear factor kappaB by direct modification in whole cells: Mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers. Biochem Pharmacol. 1998, 55: 965-973. 10.1016/S0006-2952(97)00535-2PubMedCrossRef
35.
Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB: Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J Immunol. 1999, 163: 3474-3483.PubMed
36.
Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S, Howells L: Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene. 1999, 18: 6013-6020. 10.1038/sj.onc.1202980PubMedCrossRef
37.
Chuang SE, Cheng AL, Lin JK, Kuo ML: Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food Chem Toxicol. 2000, 38: 991-995. 10.1016/S0278-6915(00)00101-0PubMedCrossRef
38.
Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS: Molecular mechanisms underlying chemoprotective activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutation Res. 2001, 480-481: 243-268.PubMedCrossRef
39.
Chuang SE, Yeh PY, Lu YS, Lai GM, Liao CM, Gao M, Cheng AL: Basal levels and patterns of anticancer drug-induced activation of nuclear factor kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells. Biochem Pharmacol. 2002, 63: 1709-1716. 10.1016/S0006-2952(02)00931-0PubMedCrossRef
40.
Nakamura K, Yasunaga Y, Segawa T, Ko D, Moul JW, Srivastava S, Rhim JS: Curcumin downregulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol. 2002, 21: 825-30.PubMed
41.
Han SS, Seo HJ, Surh YJ: Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells. J Biochem Mol Biol. 2002, 35: 337-342.PubMedCrossRef
42.
Bharti AC, Donato N, Singh S, Aggarwal BB: Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood. 2003, 101: 1053-1062. 10.1182/blood-2002-05-1320PubMedCrossRef
43.
Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ: Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis. 2003, 24: 1515-1524. 10.1093/carcin/bgg107PubMedCrossRef
44.
Shishodia S, Potdar P, Gairola CG, Aggarwal BB: Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis. 2003, 24: 1269-1279. 10.1093/carcin/bgg078PubMedCrossRef
45.
Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB: Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kB signaling. Int J Cancer. 2004, 111: 679-692. 10.1002/ijc.20333PubMedCrossRef
46.
Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE: Curcumin suppresses the paclitaxel-induced nuclear factor kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005, 11: 7490-7498. 10.1158/1078-0432.CCR-05-1192PubMedCrossRef
47.
Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M: Effects of curcumin (diferuloylmethane) on nuclear factor kappa B signaling in interleukin-1beta-stimulated chondrocytes. Ann N Y Acad Sci. 2004, 1030: 578-586. 10.1196/annals.1329.067PubMedCrossRef
48.
LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, Chakrabarti R, Srivatsan ES, Wang MB: Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res. 2005, 11: 6994-7002. 10.1158/1078-0432.CCR-05-0301PubMedCrossRef
49.
Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K, Mori N: Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int J Cancer. 2006, 118: 765-772. 10.1002/ijc.21389PubMedCrossRef
50.
Marin YE, Wall BA, Wang S, Namkoong J, Martino JJ, Suh J, Lee HJ, Rabson AB, Yang CS, Chen S, Ryu JH: Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res. 2007, 17: 274-283. 10.1097/CMR.0b013e3282ed3d0ePubMedCrossRef
51.
Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Höhneke C, Jochum M, Nerlich AG, Pfeffer U: Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NF-kappaB. Carcinogenesis. 2008, 29: 779-789. 10.1093/carcin/bgm248PubMedCrossRef
52.
Aravindan N, Madhusoodhanan R, Ahmad S, Johnson D, Herman TS: Curcumin inhibits NF-kappa B mediated radioprotection and modulates apoptosis related genes in human neuroblastoma cells. Cancer Biol Ther. 2008, 7: 569-576.PubMedCrossRef
53.
Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES, Wang MB: Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res. 2008, 14: 6228-6236. 10.1158/1078-0432.CCR-07-5177PubMedCrossRef
54.
Fiorillo C, Becatti M, Pensalfini A, Cecchi C, Lanzilao L, Donzelli G, Nassi N, Giannini L, Borchi E, Nassi P: Curcumin protects cardiac cells against ischemia reperfusion injury: effects on oxidative stress, NF-kappaB and JNK pathways. Free Radic Biol Med. 2008, 45: 839-846. 10.1016/j.freeradbiomed.2008.06.013PubMedCrossRef
55.
Hussain AR, Ahmed M, Al-Jomah NA, Khan AS, Manogaran P, Sultana M, Abubaker J, Platanias LC, Al-Kuraya KS, Uddin S: Curcumin suppresses constitutive activation of nuclear-factor kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther. 2008, 7: 3318-3329. 10.1158/1535-7163.MCT-08-0541PubMedCrossRef
56.
Kang HJ, Lee SH, Price JE, Kim LS: Curcumin suppresses the paclitaxel-induced nuclear factor kappa B in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in breast cancer nude mice model. Breast J. 2009, 15: 223-9. 10.1111/j.1524-4741.2009.00709.xPubMedCrossRef
57.
Panicker SR, Kartha CC: Curcumin attenuates glucose-induced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear-factor kappaB pathway. Pharmacology. 2010, 85: 18-26. 10.1159/000262325PubMedCrossRef
58.
Barnes PJ, Karin M: Nuclear factor-κB, a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997, 336: 1066-1071. 10.1056/NEJM199704103361506PubMedCrossRef
59.
Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM: De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature. 2004, 430: 694-699. 10.1038/nature02794PubMedCrossRef
60.
Gilmore TD: Introduction to NF-κB: players, pathways, perspectives. Oncogene. 2006, 25: 6680-6684. 10.1038/sj.onc.1209954PubMedCrossRef
61.
Brasier AR: The NF-κB regulatory network. Cardiovasc Toxicol. 2006, 6: 111-130. 10.1385/CT:6:2:111PubMedCrossRef
62.
Perkins ND: Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol. 2007, 8: 49-62. 10.1038/nrm2083PubMedCrossRef
63.
Gilmore TD: The Rel/NF-κB signal transduction pathway: introduction. Oncogene. 1999, 18: 6842-6844. 10.1038/sj.onc.1203237PubMedCrossRef
64.
Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, Aggarwal BB: Cigarette smoke condensate activates nuclear transcription factor-κB through phosphorylation and degredation of IκB(α): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002, 23: 1511-1518. 10.1093/carcin/23.9.1511PubMedCrossRef
65.
Garg A, Aggarwal BB: Nuclear transcription factor-κB as a target for cancer drug development. Leukemia. 2002, 16: 1053-1068. 10.1038/sj.leu.2402482PubMedCrossRef
66.
Ondrey FG, Dong G, Sunwoo J, Chen Z, Wolf JS, Crowl-Bancroft CV, Mukaida N, Van Waes C: Constitutive activation of transcription factors NF-(κ)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog. 1999, 26: 119-129. 10.1002/(SICI)1098-2744(199910)26:2<119::AID-MC6>3.0.CO;2-NPubMedCrossRef
67.
Arun P, Brown MS, Ehsanian R, Chen Z, Van Waes C: Nuclear NFkappa-B p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer. Clin Cancer Res. 2009, 15: 5974-5984. 10.1158/1078-0432.CCR-09-1352PubMedCentralPubMedCrossRef
68.
Ghosh S, Karin M: Missing pieces of the NF-κB puzzle. Cell. 2002, 109 ((Suppl)): S81-96. 10.1016/S0092-8674(02)00703-1PubMedCrossRef
69.
Abe Y, Hashimoto S, Horie T: Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res. 1999, 39: 41-47. 10.1006/phrs.1998.0404PubMedCrossRef
70.
71.
Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH: Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 1991, 51: 813-819.PubMed
72.
Zhang F, Altorki NK, Mestre JR, Subbaramaiah K, Dannenberg AJ: Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis. 1999, 20: 445-451. 10.1093/carcin/20.3.445PubMedCrossRef
73.
Koeberle A, Northoff H, Werz O: Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1. Mol Cancer Ther. 2009, 8: 2348-2355. 10.1158/1535-7163.MCT-09-0290PubMedCrossRef
74.
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM: The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 2001, 21 (21): 8370-8377.PubMed
75.
Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM: Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005, 280: 5892-5901. 10.1074/jbc.M404751200PubMedCrossRef
76.
Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T, Fujiyama Y, Mitsuyama K, Sata M, Yamada M, Iwaoka Y, Kanke K, Hiraishi H, Hirayama K, Arai H, Yoshii S, Uchijima M, Nagata T, Koide Y: Curcumin as maintainance therapy for ulcerative colitis: randomized, multi-center, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006, 4: 1502-1506. 10.1016/j.cgh.2006.08.008PubMedCrossRef
77.
Yadav VR, Suresh S, Devi K, Yadav S: Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease. J Pharm Pharmacol. 2009, 3: 311-321. 10.1211/jpp.61.03.0005. 10.1211/jpp.61.03.0005CrossRef
78.
Yeh CH, Chen TP, Wu YC, Lin YM, Jing Lin P: Inhibition of NFkappaB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. J Surg Res. 2005, 125: 109-116. 10.1016/j.jss.2004.11.009PubMedCrossRef
79.
Yang X, Thomas DP, Zhang X, Culver BW, Alexander BM, Murdoch WJ, Rao MN, Tulis DA, Ren J, Sreejayan N: Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation. Arterioscler Thromb Vasc Biol. 2006, 26: 85-90. 10.1161/01.ATV.0000191635.00744.b6PubMedCrossRef
80.
Babu PS, Srinivasan K: Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in an albino rat. Mol Cell Biochem. 1995, 152: 13-21.PubMed
81.
Meghana K, Sanjeev G, Ramesh B: Curcumin prevents streptozoin-induced islet damage by scavenging free radicals: a prophylactic and protective role. Eur J Pharmacol. 2007, 577: 183-191. 10.1016/j.ejphar.2007.09.002PubMedCrossRef
82.
Ram A, Das M, Ghosh B: Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs. Biol Pharm Bull. 2003, 26: 1021-1024. 10.1248/bpb.26.1021PubMedCrossRef
83.
Moon DO, Kim MO, Lee HJ: Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem Biophys Res Commun. 2008, 375: 275-279. 10.1016/j.bbrc.2008.08.025PubMedCrossRef
84.
Onodera S, Kaneda K, Mizue Y, Koyama Y, Fujinaga M, Nishihira J: Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J Biol Chem. 2000, 275: 444-450. 10.1074/jbc.275.1.444PubMedCrossRef
85.
Mun SH, Kim HS, Kim JW, Ko NY: Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/C-Jun pathway. J Pharmacol Sci. 2009, 111: 13-21. 10.1254/jphs.09134FPPubMedCrossRef
86.
Gukovsky I, Reyes CN, Vaquero EC, Gukovskaya AS, Pandol SJ: Curcumin ameliorates ethanol and nonethanol experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2003, 284: G85-95.PubMedCrossRef
87.
Durgaprasad S, Pai CG, Vasanthkumar Alvres JF, Namitha S: A pilot study of the antioxidant effects of curcumin in tropical pancreatitis. Indian J Med Res. 2005, 122: 315-318.PubMed
88.
Jones EA, Shoskes DA: The effect of mycophenolate mofetil and polyphenolic bioflavinoids on renal ischemia reperfusion injury and repair. J Urol. 2000, 163: 999-1004. 10.1016/S0022-5347(05)67871-8PubMedCrossRef
89.
Chiu J, Khan ZA, Farhangkhoee H: Curcumin prevents diabetes associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kappaB. Nutrition. 2009, 25: 964-972. 10.1016/j.nut.2008.12.007PubMedCrossRef
90.
Aggarwal BB, Harikumar KB: Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009, 41: 40-59. 10.1016/j.biocel.2008.06.010PubMedCentralPubMedCrossRef
91.
Mukhopadhyay A, Bueso-Ramos C, Chatterjee D, Pantazis P, Aggarwal BB: Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene. 2001, 20: 7597-7609. 10.1038/sj.onc.1204997PubMedCrossRef
92.
Mehta K, Pantazis P, McQueen T, Aggarwal BB: Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs. 1997, 8: 470-481. 10.1097/00001813-199706000-00010PubMedCrossRef
93.
Hanif R, Qiao L, Schiff SJ, Rigas B: Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway. J Lab Clin Med. 1997, 130: 576-584. 10.1016/S0022-2143(97)90107-4PubMedCrossRef
94.
Elattar TM, Virji AS: The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in-vitro. Anticancer Res. 2000, 20: 1733-1738.PubMed
95.
Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK: Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res. 2007, 13: 3423-3430. 10.1158/1078-0432.CCR-06-3072PubMedCrossRef
96.
Siwak DR, Shishodia S, Aggarwal BB, Kuzrock R: Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer. 2005, 104: 879-890. 10.1002/cncr.21216PubMedCrossRef
97.
Mohandas KM, Desai DC: Epidemiology of digestive tract cancers in India. V. Large and small bowel. Indian J Gastroenterol. 1999, 18: 118-121.PubMed
98.
Oda Y: Inhibitory effect of curcumin on SOS functions induced by UV irradiation. Mutat Res. 1995, 348: 67-73. 10.1016/0165-7992(95)00048-8PubMedCrossRef
99.
Thapliyal R, Maru GB: Inhibition of cytochrome p450 isoenzymes by curcumins in vitro and in vivo. Food Chem Toxicol. 2001, 39: 541-547. 10.1016/S0278-6915(00)00165-4PubMedCrossRef
100.
Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S: Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol. 2003, 92: 33-38. 10.1034/j.1600-0773.2003.920106.xPubMedCrossRef
101.
Krishnaswamy K, Goud VK, Sesikeran B, Mukundan MA, Krishna TP: Retardation of experimental tumorigenesis and reduction in DNA adducts by turmeric and curcumin. Nutr Cancer. 1998, 30: 163-166. 10.1080/01635589809514657PubMedCrossRef
102.
Inano H, Onoda M, Inafuku N, Kubota M, Kamada Y, Osawa T, Kobayashi H, Wakabayashi K: Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays. Carcinogenesis. 1999, 20: 1011-1018. 10.1093/carcin/20.6.1011PubMedCrossRef
103.
Collett GP, Robson CN, Mathers JC, Campbell FC: Curcumin modifies Apc(min) apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) induced tumour formation in Apc(min) mice. Carcinogenesis. 2001, 22: 821-825. 10.1093/carcin/22.5.821PubMedCrossRef
104.
Hess J, Angel P, Schorpp-Kistner M: AP-1 subunits: quarrel and harmony among siblings. J Cell Sci. 2004, 117: 5965-5973. 10.1242/jcs.01589PubMedCrossRef
105.
Hsu TC, Young MR, Cmarik J, Colburn NH: Activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB) dependent transcriptional events in carcinogenesis. Free Radic Biol Med. 2000, 28: 1338-1348. 10.1016/S0891-5849(00)00220-3PubMedCrossRef
106.
Shaulian E, Karin M: AP-1 in cell proliferation and survival. Oncogene. 2001, 20: 2390-2400. 10.1038/sj.onc.1204383PubMedCrossRef
107.
108.
Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB: Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int J Cancer. 2009, 125: 2187-2197. 10.1002/ijc.24593PubMedCrossRef
109.
Tharakan ST, Inamoto T, Sung B, Aggarwal BB, Kamat AM: Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers. Biochem Pharmacol. 2010, 79: 218-228. 10.1016/j.bcp.2009.08.007PubMedCentralPubMedCrossRef
110.
Park CH, Lee JH, Yang CH: Curcumin derivatives inhibit the formation of Jun-Fos-DNA complex independently of their conserved cysteine residues. J Biochem Mol Biol. 2005, 38: 474-480.PubMedCrossRef
111.
112.
Elledge SJ: Cell cycle checkpoints: preventing an identity crisis. Science. 1996, 274: 1664-1672. 10.1126/science.274.5293.1664PubMedCrossRef
113.
Nurse P, Masui Y, Hartwell L: Understanding the cell cycle. Nat Med. 1998, 4: 1103-1106. 10.1038/2594PubMedCrossRef
114.
Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999, 13: 1501-1512. 10.1101/gad.13.12.1501PubMedCrossRef
115.
Cánepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF: INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions. IUBMB Life. 2007, 59: 419-426.PubMedCrossRef
116.
Delston RB, Harbour JW: Rb at the interface between cell cycle and apoptotic decisions. Curr Mol Med. 2006, 6: 713-718.PubMed
117.
Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ: Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 1993, 7: 331-342. 10.1101/gad.7.3.331PubMedCrossRef
118.
Park MJ, Kim EH, Park IC, Lee HC, Woo SH, Lee JY, Hong YJ, Rhee CH, Choi SH, Shim BS, Lee SH, Hong SI: Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int J Oncol. 2002, 21: 379-383.PubMed
119.
Mukhopadhyay A, Banerjee S, Stafford LJ, Xia C, Liu M, Aggarwal BB: Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Cell Cycle. 2007, 6: 2953-2961. 10.4161/cc.6.23.4951CrossRef
120.
Senderowicz AM: Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms. Cancer Chemother Pharmacol. 2003, 52 ((Suppl 1)): S61-73. 10.1007/s00280-003-0624-xPubMedCrossRef
121.
Hall M, Peters G: Genetic alterations of cyclins, cyclin-dependant kinases, and Cdk inhibitors in human cancer. Adv Cancer Res. 1996, 68: 67-108. full_textPubMedCrossRef
122.
Liu Q, Loo WT, Sze SC, Tong Y: Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. Phytomedicine. 2009, 16: 916-922. 10.1016/j.phymed.2009.04.008PubMedCrossRef
123.
Singh M, Singh N: Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Mol Cell Biochem. 2009, 325: 107-119. 10.1007/s11010-009-0025-5PubMedCrossRef
124.
Wang Z, Desmoulin S, Banerjee S, Kong D, Li Y, Deraniyagala RL, Abbruzzese J, Sarkar FH: Synergistic effects of multiple natural products in pancreatic cancer cells. Life Sci. 2008, 83: 293-300. 10.1016/j.lfs.2008.06.017PubMedCentralPubMedCrossRef
125.
Wang Y, Okan I, Szekely L, Klein G, Wiman KG: Bcl-2 inhibits wild-type p53-triggered apoptosis but not G1 cell cycle arrest and transactivation of WAF1 and Bax. Cell Growth Differ. 1995, 6: 1071-1075.PubMed
126.
Liu X, Kim CN, Yang J, Jemmerson R, Wang X: Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome C. Cell. 1996, 86: 147-157. 10.1016/S0092-8674(00)80085-9PubMedCrossRef
127.
Choudhuri T, Pal S, Das T, Sa G: Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependant manner. J Biol Chem. 2005, 280: 20059-20068. 10.1074/jbc.M410670200PubMedCrossRef
128.
Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, Tridandapani S, Anant S, Kuppusamy P: Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther. 2007, 6: 178-184. 10.4161/cbt.6.2.3577PubMedCentralPubMedCrossRef
129.
Liu E, Wu J, Cao W, Zhang J, Liu W, Jiang X, Zhang X: Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. J Neurooncol. 2007, 85: 263-270. 10.1007/s11060-007-9421-4PubMedCrossRef
130.
Gajate C, Mollinedo F: Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J Biol Chem. 2005, 280: 11641-11647. 10.1074/jbc.M411781200PubMedCrossRef
131.
Lu HF, Lai KC, Hsu SC, Lin HJ, Yang MD, Chen YL, Fan MJ, Yang JS, Cheng PY, Kuo CL, Chung JG: Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells. Oncol Rep. 2009, 22: 97-104.PubMed
132.
Bush JA, Cheung KJ, Li G: Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Exp Cell Res. 2001, 271: 305-314. 10.1006/excr.2001.5381PubMedCrossRef
133.
Freudlsperger C, Greten J, Schumacher U: Curcumin induces apoptosis in human neuroblastoma cells via inhibition of NFkappaB. Anticancer Res. 2008, 28: 209-214.PubMed
134.
Shankar S, Ganapathy S, Chen Q, Srivastava RK: Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Mol Cancer. 2008, 7: 16- 10.1186/1476-4598-7-16PubMedCentralPubMedCrossRef
135.
Singletary K, Milner J: Diet, autophagy and cancer: a review. Cancer Epidemiol Biomarkers Prev. 2008, 17: 1596-1610. 10.1158/1055-9965.EPI-07-2917PubMedCrossRef
136.
Edinger AL, Thompson CB: Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol. 2004, 16: 663-669. 10.1016/j.ceb.2004.09.011PubMedCrossRef
137.
Indelicato M, Pucci B, Schito L, Reali V, Aventaggiato M, Mazzarino MC, Stivala F, Fini M, Russo MA, Tafani M: Role of hypoxia and autophagy in MDA-MB-231 invasiveness. J Cell Physiol. 2010, 223: 359-368.PubMed
138.
Kang C, Avery L: To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Autophagy. 2008, 4: 82-84.PubMedCentralPubMedCrossRef
139.
Alva AS, Gultekin SH, Baehrecke EH: Autophagy in human tumors: cell survival or death?. Cell Death Differ. 2004, 11: 1046-1048. 10.1038/sj.cdd.4401445PubMedCrossRef
140.
Harhaji-Trajkovic L, Vilimanovich U, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V: AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumor cells. J Cell Mol Med. 2009, 13: 3644-3654. 10.1111/j.1582-4934.2009.00663.xPubMedCentralPubMedCrossRef
141.
Li J, Qin Z, Liang Z: The prosurvival role of autophagy in resveratrol-induced cytotoxicity in human U251 glioma cells. BMC Cancer. 2009, 9: 215- 10.1186/1471-2407-9-215PubMedCentralPubMedCrossRef
142.
Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, Galavotti S, Young KW, Selmi T, Yacobi R, Van Etten RA, Donato N, Hunter A, Dinsdale D, Tirrò E, Vigneri P, Nicotera P, Dyer MJ, Holyoake T, Salomoni P, Calabretta B: Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest. 2009, 119: 1109-1123. 10.1172/JCI35660PubMedCentralPubMedCrossRef
143.
Namgoong GM, Khanal P, Cho HG, Lim SC, Oh YK, Kang BS, Shim JH, Yoo JC, Choi HS: The prolyl-isomerase pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer. J Biol Chem. 2010, 285: 23829-23841. 10.1074/jbc.M109.092874PubMedCentralPubMedCrossRef
144.
Samaddar JS, Gaddy VT, Duplantier J, Thandavan SP, Shah M, Smith MJ, Browning D, Rawson J, Smith SB, Barrett JT, Schoenlein PV: A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance. Mol Cancer Ther. 2008, 7: 2977-2987. 10.1158/1535-7163.MCT-08-0447PubMedCrossRef
145.
Ren JH, He WS, Nong L, Zhu QY, Hu K, Zhang RG, Huang LL, Zhu F, Wu G: Acquired cisplatin resistance in human lung adenocarcinoma cells is associated with enhanced autophagy. Cancer Biother Radiopharm. 2010, 25: 75-80. 10.1089/cbr.2009.0701PubMedCrossRef
146.
Song J, Qu Z, Guo X, Zhao Q, Zhao X, Gao L, Sun K, Shen F, Wu M, Wei L: Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy. 2009, 5: 1131-1144. 10.4161/auto.5.8.9996PubMedCrossRef
147.
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B: Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999, 402: 672-676. 10.1038/45257PubMedCrossRef
148.
Yue Z, Jin S, Yang C, Levine AJ, Heintz N: Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA. 2003, 100: 15077-15082. 10.1073/pnas.2436255100PubMedCentralPubMedCrossRef
149.
Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003, 112: 1809-1820.PubMedCentralPubMedCrossRef
150.
Bursch W, Ellinger A, Kienzl H, Török L, Pandey S, Sikorska M, Walker R, Hermann RS: Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis. 1996, 17: 1595-1607. 10.1093/carcin/17.8.1595PubMedCrossRef
151.
Górka M, Daniewski WM, Gajkowska B, Lusakowska E, Godlewski MM, Motyl T: Autophagy is the dominant type of programmed cell death in breast cancer MCF-7 cells exposed to AGS 115 and EFDAC, new sesquiterpene analogs of paclitaxel. Anticancer Drugs. 2005, 16: 777-788.PubMedCrossRef
152.
Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I: Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res. 2003, 63: 2103-2108.PubMed
153.
Qian W, Liu J, Jin J, Ni W, Xu W: Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leuk Res. 2007, 31: 329-339. 10.1016/j.leukres.2006.06.021PubMedCrossRef
154.
Chiu HW, Lin JH, Chen YA, Ho SY, Wang YJ: Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy. 2010, 6: 353-365. 10.4161/auto.6.3.11229PubMedCrossRef
155.
Ertmer A, Huber V, Gilch S, Yoshimori T, Erfle V, Duyster J, Elsässer HP, Schätzl HM: The anticancer drug imatinib induces cellular autophagy. Leukemia. 2007, 21: 936-942.PubMed
156.
Basciani S, Vona R, Matarrese P, Ascione B, Mariani S, Cauda R, Gnessi L, Malorni W, Straface E, Lucia MB: Imatinib interferes with survival of multi drug resistant Kaposi's sarcoma cells. FEBS Lett. 2007, 581: 5897-5903. 10.1016/j.febslet.2007.11.069PubMedCrossRef
157.
Katayama M, Kawaguchi T, Berger MS, Pieper RO: DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells. Cell Death Differ. 2007, 14: 548-558. 10.1038/sj.cdd.4402030PubMedCrossRef
158.
Gewirtz DA, Hilliker ML, Wilson EN: Promotion of autophagy as a mechanism for radiation sensitization of breast cancer cells. Radiother Oncol. 2009, 92: 323-328. 10.1016/j.radonc.2009.05.022PubMedCrossRef
159.
Zhuang W, Qin Z, Liang Z: The role of autophagy in sensitizing malignant glioma cells to radiation therapy. Acta Biochim Biophys Sin (Shanghai). 2009, 41: 341-351. 10.1093/abbs/gmp028CrossRef
160.
Lomonaco SL, Finniss S, Xiang C, Decarvalho A, Umansky F, Kalkanis SN, Mikkelsen T, Brodie C: The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer. 2009, 125: 717-722. 10.1002/ijc.24402PubMedCrossRef
161.
Jia YL, Li J, Qin ZH, Liang ZQ: Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells. J Asian Nat Prod Res. 2009, 11: 918-928. 10.1080/10286020903264077PubMedCrossRef
162.
O'Sullivan-Coyne G, O'Sullivan GC, O'Donovan TR: Curcumin induces apoptosis-independent death in oesophageal cancer cells. Br J Cancer. 2009, 101: 1585-1595.PubMedCentralPubMedCrossRef
163.
Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y: Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol. 2007, 72: 29-39. 10.1124/mol.106.033167PubMedCrossRef
164.
Shinojima N, Yokoyama T, Kondo Y, Kondo S: Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy. 2007, 3: 635-637.PubMedCrossRef
165.
Cao Y, Liu Q: Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis. Adv Cancer Res. 2007, 97: 203-224. full_textPubMedCrossRef
166.
Barrascout E, Medioni J, Scotte F: Angiogenesis inhibition: review of the activity of sorafenib, sunitinib and bevacizumab. Bull Cancer. 2010, 97: 29-43.PubMed
167.
Perry MC, Demeule M, Régina A, Moumdjian R, Béliveau R: Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts. Mol Nutr Food Res. 2010
168.
Yoysungnoen P, Wirachwong P, Changtam C, Suksamrarn A, Patumraj S: Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. World J Gastroenterol. 2008, 14: 2003-2009. 10.3748/wjg.14.2003PubMedCentralPubMedCrossRef
169.
Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK: Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res. 2007, 13: 3423-3430. 10.1158/1078-0432.CCR-06-3072PubMedCrossRef
170.
Gururaj AE, Belakavadi M, Venkatesh DA, Marmé D, Salimath BP: Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem Biophys Res Commun. 2002, 297: 934-942. 10.1016/S0006-291X(02)02306-9PubMedCrossRef
171.
Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, Raizman MB, Fini ME: Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000, 275: 10405-10412. 10.1074/jbc.275.14.10405PubMedCrossRef
172.
Yoysungnoen P, Wirachwong P, Bhattarakosol P, Niimi H, Patumraj S: Effects of curcumin on tumor angiogenesis and biomarkers, COX-2 and VEGF, in hepatocellular carcinoma cell-implanted nude mice. Clin Hemorheol Microcirc. 2006, 34: 109-115.PubMed
173.
Ray S, Chattopadhyay N, Mitra A, Siddiqi M, Chatterjee A: Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin. J Environ Pathol Toxicol Oncol. 2003, 22: 49-58.PubMed
174.
Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA: Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 2008, 68: 3645-3654. 10.1158/0008-5472.CAN-07-2938PubMedCrossRef
175.
Yodkeeree S, Ampasavate C, Sung B, Aggarwal BB, Limtrakul P: Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line. Eur J Pharmacol. 2010, 627: 8-15. 10.1016/j.ejphar.2009.09.052PubMedCrossRef
176.
Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, Bueso-Ramos CE, Price JE: Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res. 2005, 11: 7490-7498. 10.1158/1078-0432.CCR-05-1192PubMedCrossRef
177.
Chakravarti N, Myers JN, Aggarwal BB: Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane). Int J Cancer. 2006, 119: 1268-1275. 10.1002/ijc.21967PubMedCrossRef
178.
Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R: Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prev Res. 2010, 3: 331-338. 10.1158/1940-6207.CAPR-09-0076. 10.1158/1940-6207.CAPR-09-0076CrossRef
179.
Chang KW, Hung PS, Lin IY, Hou CP, Chen LK, Tsai YM, Lin SC: Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression. Int J Cancer. 2010, 127: 9-20. 10.1002/ijc.25383PubMedCrossRef
180.
Cohen AN, Veena MS, Srivatsan ES, Wang MB: Supression of Interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase. Arch Otolaryngol Head Neck Surg. 2009, 135: 190-197. 10.1001/archotol.135.2.190PubMedCrossRef
181.
Lin L, Hutzen B, Ball S, Foust E, Foust E, Sobo M, Deangelis S, Pandit B, Friedman L, Li C, Li PK, Fuchs J, Lin J: New curcumin analogues exhibit enhanced growth-suppressive activity and inhibit AKT and signal transducer and activator of transcription 3 phosphorylation in breast and prostate cancer cells. Cancer Sci. 2009, 100: 1719-1727. 10.1111/j.1349-7006.2009.01220.xPubMedCrossRef
182.
Crowell JA, Steele VE, Fay JR: Targeting the AKT protein kinase for cancer chemoprevention. Mol Cancer Ther. 2007, 6: 2139-2148. 10.1158/1535-7163.MCT-07-0120PubMedCrossRef
183.
Bisht S, Maitra A: Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Curr Drug Discov Technol. 2009, 6: 192-199. 10.2174/157016309789054933PubMedCrossRef
184.
Li L, Braiteh FS, Kurzrock R: Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer. 2005, 104: 1322-1331. 10.1002/cncr.21300PubMedCrossRef
185.
Li L, Ahmed B, Mehta K, Kurzrock R: Liposomal curcumin with and without oxaliplatin: effects on cell growth, apoptosis, and angiogenesis in colorectal cancer. Mol Cancer Ther. 2007, 6: 1276-1282. 10.1158/1535-7163.MCT-06-0556PubMedCrossRef
186.
Mach CM, Mathew L, Mosley SA, Kurzrock R, Smith JA: Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model. Anticancer Res. 2009, 29: 1895-1899.PubMed
187.
Clark CA, McEachern MD, Shah SH, Rong Y, Rong X, Smelley CL, Caldito G, Abreo F, Nathan CA: Curcumin Inhibits Carcinogen and Nicotine-induced Mammalian Target of Rapamycin Pathway Activation in Head and Neck Squamous Cell Carcinoma. Cancer Prev Res. 2010, 3: 1586-1595. 10.1158/1940-6207.CAPR-09-0244. 10.1158/1940-6207.CAPR-09-0244CrossRef
188.
Duarte VM, Han EH, Veena MS, Salvado A, Suh JD, Liang L-J, Faull KF, Srivatsan ES, Wang MB: Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma via inhibition of IkKB protein of the nuclear factor kB. Mol Cancer Ther. 2010, 9: 2665-2675. 10.1158/1535-7163.MCT-10-0064PubMedCentralPubMedCrossRef
189.
Khafif A, Lev-Ari S, Vexler A, Barnea I, Starr A, Karaush V, Haif S, Ben-Yosef R: Curcumin: a potential radio-enhancer in head and neck cancer. Laryngoscope. 2009, 119: 2019-2026. 10.1002/lary.20582PubMedCrossRef
190.
Jagetia JC: Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol. 2007, 595: 301-320. full_textPubMedCrossRef
191.
Chendil D, Ranga RS, Meigooni D, Sathishkumar S, Ahmed MM: Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene. 2004, 23: 1599-1607. 10.1038/sj.onc.1207284PubMedCrossRef
192.
Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB, Krishnan S: Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int J Radiat Oncol Biol Phys. 2009, 75: 534-542. 10.1016/j.ijrobp.2009.06.034PubMedCentralPubMedCrossRef
193.
Yallapu MM, Maher DM, Sundram V, Bell MC, Jaggi M, Chauhan SC: Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res. 2010, 3: 11- 10.1186/1757-2215-3-11PubMedCentralPubMedCrossRef
194.
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA. 2006, 100: 3983-3988. 10.1073/pnas.0530291100. 10.1073/pnas.0530291100CrossRef
195.
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE: A cell initiating human acute myeloid leukemia after transplanataion into SCID mice. Nature. 2004, 17: 645-648.
196.
Prince ME, Sivanadan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, Weissman IL, Clarke MF, Ailles LE: Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA. 2007, 104: 973-978. 10.1073/pnas.0610117104PubMedCentralPubMedCrossRef
197.
Collins AT, Berry PA, Hyde C, Stower MJ, Maitland NJ: Prospective identification of tumorigenic prostate cancer cells. Cancer Res. 2005, 65: 10946-10951. 10.1158/0008-5472.CAN-05-2018PubMedCrossRef
198.
Kondo T, Setoguchi T, Taga T: Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA. 2004, 101: 781-786. 10.1073/pnas.0307618100PubMedCentralPubMedCrossRef
199.
O'Brien CA, Pollett A, Gallinger S, Gallinger S, Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007, 445: 111-115.CrossRef
200.
Harper L, Piper K, Common J, Fortune F, Mackenzie IC: Stem cell patterns in cell lines derived from head & neck squamous cell carcinoma. J Oral Pathol Med. 2007, 36: 594-603. 10.1111/j.1600-0714.2007.00617.xPubMedCrossRef
201.
Wu A, Veena MS, Basak SA, Wang MB, Srivatsan ES: CD44High head and neck cancer cells demonstrate increased cell growth and chemotherapeutic resistance [Abstract]. Amer Assoc Cancer Res. 2010, 51: s3316-CrossRef
202.
Bourhis J, Rivera F, Mesia R, Awada A, Geoffrois L, Borel C, Humblet Y, Lopez-Pousa A, Hitt R, Vega Villegas ME, Duck L, Rosine D, Amellal N, Schueler A, Harstrick A: Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 2006, 24: 2866-2872. 10.1200/JCO.2005.04.3547PubMedCrossRef
203.
Morgillo F, Bareschino MA, Bianco R, Tortora G, Ciardiello F: Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy. Differentiation. 2007, 75: 788-799. 10.1111/j.1432-0436.2007.00200.xPubMedCrossRef
204.
Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, Gooding WE, Furnari FB, Grandis JR: Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res. 2006, 12: 5064-5073. 10.1158/1078-0432.CCR-06-0913PubMedCrossRef
205.
Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL: Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol. 2004, 22: 77-85. 10.1200/JCO.2004.06.075PubMedCrossRef
206.
Stewart JS, Cohen EE, Licitra L, Van Herpen CM, Khorprasert C, Soulieres D, Vodvarka P, Rischin D, Garin AM, Hirsch FR, Varella-Garcia M, Ghiorghiu S, Hargreaves L, Armour A, Speake G, Swaisland A, Vokes EE: Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck. J Clin Oncol. 2009, 27: 1864-1871. 10.1200/JCO.2008.17.0530PubMedCrossRef
207.
Cohen EE, Haraf DJ, Kunnavakkam R, Stenson KM, Blair EA, Brockstein B, Lester EP, Salama JK, Dekker A, Williams R, Witt ME, Grushko TA, Dignam JJ, Lingen MW, Olopade OI, Vokes EE: Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol. 2010, 28: 3336-3343. 10.1200/JCO.2009.27.0397PubMedCentralPubMedCrossRef
208.
Fujita K, Sano D, Kimura M, Yamashita Y, Kawakami M, Ishiguro Y, Nishimura G, Matsuda H, Tsukuda M: Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma. Oncol Rep. 2007, 18: 47-51.PubMed
209.
Cohen EE, Davis DW, Karrison TG, Seiwert TY, Wong SJ, Nattam S, Kozloff MF, Clark JI, Yan DH, Liu W, Pierce C, Dancey JE, Stenson K, Blair E, Dekker A, Vokes EE: Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. Lancet Oncol. 2009, 10: 247-257. 10.1016/S1470-2045(09)70002-6PubMedCentralPubMedCrossRef
210.
Bussink J, van der Kogel AJ, Kaanders JH: Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol. 2008, 9: 288-296. 10.1016/S1470-2045(08)70073-1PubMedCrossRef
211.
Nathan CO, Amirghahari N, Rong X, Giordano T, Sibley D, Nordberg M, Glass J, Agarwal A, Caldito G: Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer. Cancer Res. 2007, 67: 2160-2168. 10.1158/0008-5472.CAN-06-2449PubMedCrossRef
212.
Ekshyyan O, Rong Y, Rong X, Pattani KM, Abreo F, Caldito G, Chang JK, Ampil F, Glass J, Nathan CO: Comparison of radiosensitizing effects of the mammalian target of rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell carcinoma. Mol Cancer Ther. 2009, 8: 2255-2265. 10.1158/1535-7163.MCT-08-1184PubMedCentralPubMedCrossRef
213.
Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006, 66: 11851-11858. 10.1158/0008-5472.CAN-06-1377PubMedCrossRef
214.
Williamson SK, Moon J, Huang CH, Guaglianone PP, LeBlanc M, Wolf GT, Urba SG: Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420. J Clin Oncol. 2010, 28: 3330-3335. 10.1200/JCO.2009.25.6834PubMedCentralPubMedCrossRef
215.
Specenier PM, Ciuleanu T, Latz JE, Musib LC, Darstein CL, Vermorken JB: Pharmacokinetic evaluation of platinum derived from cisplatin administered alone and with pemetrexed in head and neck cancer patients. Cancer Chemother Pharmacol. 2009, 64: 233-241. 10.1007/s00280-008-0853-0PubMedCrossRef
216.
Fury MG, Haque S, Stambuk H, Shen R, Carlson D, Pfister D: A phase 2 study of pemetrexed plus gemcitabine every 2 weeks for patients with recurrent or metastatic head and neck squamous cell cancer. Cancer. 2010
217.
Allen C, Saigal K, Nottingham L, Arun P, Chen Z, Van Waes C: Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer. Clin Cancer Res. 2008, 14: 4175-4185. 10.1158/1078-0432.CCR-07-4470PubMedCrossRef
218.
Li C, Li R, Grandis JR, Johnson DE: Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells. Mol Cancer Ther. 2008, 7: 1647-1655. 10.1158/1535-7163.MCT-07-2444PubMedCentralPubMedCrossRef
219.
Chung CH, Aulino J, Muldowney NJ, Hatakeyama H, Baumann J, Burkey B, Netterville J, Sinard R, Yarbrough WG, Cmelak AJ, Slebos RJ, Shyr Y, Parker J, Gilbert J, Murphy BA: Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol. 2010, 21: 864-870. 10.1093/annonc/mdp390PubMedCentralPubMedCrossRef
Metadata
Title
Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma
Authors
Reason Wilken
Mysore S Veena
Marilene B Wang
Eri S Srivatsan
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2011
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-10-12

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