Published in:
Open Access
01-10-2012 | Poster presentation
Recognition of Plasmodium falciparum gametocyte surface antigens by plasma antibodies in asymptomatic Ghanaian school children
Authors:
Bismarck Dinko, Teun Bousema, Colin J Sutherland
Published in:
Malaria Journal
|
Special Issue 1/2012
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Excerpt
Malaria transmission-reducing interventions are key components of malaria control and elimination [
1]. However, little is known about the immune responses directed at circulating
Plasmodium falciparum gametocytes in humans, knowledge of which would be useful in the development of anti-gametocyte vaccines, which would have the capability to reduce malaria transmission from humans to mosquitoes. In a study in the Gambia, mature gametocyte-infected erythrocytes of
P. falciparum were found to carry antigens (gametocyte surface antigens, GSA) that were recognised by malaria patient’s plasma antibodies. These anti-GSA antibodies, taken at a single timepoint, were weakly associated with lower duration of gametocyte carriage in these treated patients [
2,
3]. We then sought to determine longitudinal patterns in GSA antibody prevalence and its relationship to possible immune suppression of gametocyte carriage
in vivo. …