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Open Access 01-12-2006 | Original investigation

Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome

Authors: Uli C Broedl, Michael Lehrke, Elisabeth Fleischer-Brielmaier, Anne B Tietz, Jutta M Nagel, Burkhard Göke, Peter Lohse, Klaus G Parhofer

Published in: Cardiovascular Diabetology | Issue 1/2006

Abstract

Background

Adiponectin acts as an antidiabetic, antiinflammatory and antiatherogenic adipokine. These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR1 and AdipoR2.

Aim

The purpose of this study was to determine whether variations in the AdipoR1 and AdipoR2 genes may contribute to insulin resistance, dyslipidemia and inflammation.

Methods

We sequenced all seven coding exons of both genes in 20 unrelated German subjects with metabolic syndrome and tested genetic variants for association with glucose, lipid and inflammatory parameters.

Results

We identified three AdipoR2 variants (+795G/A, +870C/A and +963C/T) in perfect linkage disequilibrium (r² = 1) with a minor allele frequency of 0.125. This haplotype was associated with higher plasma adiponectin levels and decreased fasting triglyceride, VLDL-triglyceride and VLDL-cholesterol levels. No association, however, was observed between the AdipoR2 SNP cluster and glucose metabolism.

Conclusion

To our knowledge, this is the first study to identify an association between genetic variants of the adiponectin receptor genes and plasma adiponectin levels. Furthermore, our data suggest that AdipoR2 may play an important role in triglyceride/VLDL metabolism.

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Title: Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome
Authors: Uli C Broedl
Michael Lehrke
Elisabeth Fleischer-Brielmaier
Anne B Tietz
Jutta M Nagel
Burkhard Göke
Peter Lohse
Klaus G Parhofer
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: Cardiovascular Diabetology / Issue 1/2006
Electronic ISSN: 1475-2840
DOI: https://doi.org/10.1186/1475-2840-5-11

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