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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2011

Open Access 01-12-2011 | Original investigation

Heart-Type Fatty Acid Binding Protein (H-FABP): Relationship with arterial ıntima-media thickness and role as diagnostic marker for atherosclerosis in patients with ımpaired glucose metabolism

Authors: Basak Karbek, Mustafa Özbek, Nujen Colak Bozkurt, Zeynep Ginis, Askın Güngünes, İlknur Öztürk Ünsal, Erman Cakal, Tuncay Delibası

Published in: Cardiovascular Diabetology | Issue 1/2011

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Abstract

Background

Heart type fatty acid binding protein (H-FABP) has been closely associated with acute coronary syndrome, cardiac abnormalities, stroke, and obstructive sleep disorder in previous studies. The aim of this study was to evaluate and compare the serum H-FABP levels and carotid artery intima-media thickness (CIMT) between patients with prediabetes and control subjects.

Research design and methods

We measured serum H-FABP levels in 58 prediabetic patients, 29 with impaired fasting glucose (IFG) and 29 with impaired glucose tolerance (IGT) and 28 age-, sex- and body mass index-matched control subjects using a sandwich enzyme-linked immunosorbent assay (ELISA), and in order to measure CIMT, all participants underwent high-resolution B-mode ultrasonography.

Results

Serum H-FABP levels were significantly elevated in pre-diabetic patients when compared with that of control subjects (IFG: 32.5 ± 34.2 ng/dL, IGT: 45.4 ± 45.8 ng/dL, control: 16.8 ± 14.9 ng/dL; p = 0.011). The difference in means of H-FABP levels between patients with IGT or IFG and control subjects was significant (p = 0.010 and p = 0.009, respectively). CIMT was higher in the pre-diabetic groups compared with the control group (IFG: 0.6 ± 0.1, IGT: 0.6 ± 0.1, control: 0.5 ± 0.1; p < 0.001), and H-FABP level was positively correlated with CIMT (p < 0.001, rho = 0.626).

Conclusion

Our results indicate that patients with pre-diabetes are at increased risk for cardiovascular disease. In addition, serum H-FABP levels could represent a useful marker for myocardial performance in patients with IFG and IGT.
Appendix
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Literature
1.
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997, 20: 1183-97.CrossRef
2.
Expert Committee on the Diagnosis and Classification of DiabetesMellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2000, 23: S4-19.
3.
Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabetic Med. 1998, 15: 539-53. 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S.CrossRefPubMed
4.
Zhang L, Qiao Q, Tuomilehto J, Hammar N, Alberti KG, Eliasson M, Heine RJ, Stehouwer CD, Ruotolo G, DECODE Study Group: Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study. Diabetes Res Clin Pract. 2008, 82: 364-77. 10.1016/j.diabres.2008.08.022.CrossRefPubMed
5.
Unwin N, Shaw J, Zimmet P, Alberti KG: Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. Diabet Med. 2002, 19: 708-23.CrossRefPubMed
6.
Faeh D, William J, Yerly P, Paccaud F, Bovet P: Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity. Cardiovasc Diabetol. 2007, 6: 32-10.1186/1475-2840-6-32.PubMedCentralCrossRefPubMed
7.
Janssen PG, Gorter KJ, Stolk RP, Rutten GE: Screen detected subjects with type 2 diabetes and impaired glucose tolerance have more adverse cardiovascular risk than subjects with impaired fasting glucose especially when they are obese: the ADDITION Netherlands study. Prim Care Diabetes. 2007, 1: 69-74. 10.1016/j.pcd.2007.02.001.CrossRefPubMed
8.
Petersen JL, McGuire DK: Impaired glucose tolerance and impaired fasting glucose--a review of diagnosis, clinical implications and management. Diab Vasc Dis Res. 2005, 2: 9-15. 10.3132/dvdr.2005.007.CrossRefPubMed
9.
Temelkova-Kurktschiev TS, Koehler C, Henkel E, Leonhardt W, Fuecker K, Hanefeld M: Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level. Diabetes Care. 2000, 23: 1830-4. 10.2337/diacare.23.12.1830.CrossRefPubMed
10.
Fournier NC, Richard MA: Role of fatty acid-binding protein in cardiac fatty acid oxidation. Mol Cell Biochem. 1990, 98: 149-59.CrossRefPubMed
11.
Pelsers MM, Hermens WT, Glatz JF: Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta. 2005, 352: 15-35. 10.1016/j.cccn.2004.09.001.CrossRefPubMed
12.
Nagahara D, Nakata T, Hashimoto A, Takahashi T, Kyuma M, Hase M, Tsuchihashi K, Shimamoto K: Early positive biomarker in relation to myocardial necrosis and impaired fatty acid metabolism in patients presenting with acute chest pain at an emergency room. Circ J. 2006, 70: 419-25. 10.1253/circj.70.419.CrossRefPubMed
13.
Mitsuhashi N, Onuma T, Kubo S, Takayanagi N, Honda M, Kawamori R: Coronary artery disease and carotid artery intima-media thickness in Japanese type 2 diabetic patients. Diabetes Care. 2002, 25: 1308-12. 10.2337/diacare.25.8.1308.CrossRefPubMed
14.
Brohall G, Odén A, Fagerberg B: Carotid artery intima-media thickness in patients with Type 2 diabetes mellitus and impaired glucose tolerance: a systematic review. Diabet Med. 2006, 23: 609-16.CrossRefPubMed
15.
World Health Organization: Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia. Report of a WHO/IDF Consultation. Geneva. 2006, World Health Org
16.
Burton PB, Hogben CE, Joannou CL, Clark AG, Hsuan JJ, Totty NF, Sorensen C, Evans RW, Tynan MJ: Heart fatty acid binding protein is a novel regulator of cardiac myocyte hypertrophy. Biochem Biophys Res Commun. 1994, 205: 1822-8. 10.1006/bbrc.1994.2882.CrossRefPubMed
17.
Glatz JF, Kleine AH, van Nieuwenhoven FA, Hermens WT, van Dieijen-Visser MP, van der Vusse GJ: Fatty-acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans. Br Heart J. 1994, 71: 135-40. 10.1136/hrt.71.2.135.PubMedCentralCrossRefPubMed
18.
Tanaka T, Hirota Y, Sohmiya K, Nishimura S, Kawamura K: Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction. Clin Biochem. 1991, 24: 195-201. 10.1016/0009-9120(91)90571-U.CrossRefPubMed
19.
Viswanathan K, Kilcullen N, Morrell C, Thistlethwaite SJ, Sivananthan MU, Hassan TB, Barth JH, Hall AS: Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative. J Am Coll Cardiol. 2010, 55: 2590-8. 10.1016/j.jacc.2009.12.062.CrossRefPubMed
20.
Orak M, Ustündağ M, Güloğlu C, Ozhasenekler A, Alyan O, Kale E: The role of the heart-type fatty acid binding protein in the early diagnosis of acute coronary syndrome and its comparison with troponin I and creatine kinase-MB isoform. Am J Emerg Med. 2010, 28: 891-6. 10.1016/j.ajem.2009.05.012.CrossRefPubMed
21.
Kim KS, Lee HJ, Kim K, Jo YH, Kim TY, Lee JH, Rhee JE, Suh GJ, Kim MR, Lee CC, Singer AJ: Heart-type fatty acid binding protein as an adjunct to cardiac troponin-I for the diagnosis of myocardial infarction. J Korean Med Sci. 2011, 26 (1): 47-52.PubMedCentralCrossRefPubMed
22.
Figiel Ł, Wraga M, Bednarkiewicz Z, Lipiec P, Smigielski J, Krzemińska-Pakuła M, Kasprzak JD: Direct comparison of the diagnostic value of point-of-care tests detecting heart-type fatty acid binding protein or glycogen phosphorylase isoenzyme BB in patients with acute coronary syndromes with persistent ST-segment elevation. Kardiol Pol. 2011, 69 (1): 1-6.PubMed
23.
Boscheri A, Wunderlich C, Langer M, Schoen S, Wiedemann B, Stolte D, Elmer G, Barthel P, Strasser RH: Correlation of heart-type fatty acid-binding protein with mortality and echocardiographic data in patients with pulmonary embolism at intermediate risk. Am Heart J. 2010, 160: 294-300. 10.1016/j.ahj.2010.05.010.CrossRefPubMed
24.
Akbal E, Özbek M, Güneş F, Akyürek Ö, Üreten K, Delibaşı T: Serum heart type fatty acid binding protein levels in metabolic syndrome. Endocrine. 2009, 36: 433-7. 10.1007/s12020-009-9243-6.CrossRefPubMed
25.
Glatz JF, van Breda E, Keizer HA, de Jong YF, Lakey JR, Rajotte RV, Thompson A, van der Vusse GJ, Lopaschuk GD: Rat heart fatty acid-binding protein content is increased in experimental diabetes. Biochem Biophys Res Commun. 1994, 199 (2): 639-46. 10.1006/bbrc.1994.1276.CrossRefPubMed
26.
Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R: Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation. 1986, 74: 1399-406.CrossRefPubMed
27.
Salonen JT, Salonen R: Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation. 1993, 87: II56-65.PubMed
28.
Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE: Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation. 1997, 96: 1432-437.CrossRefPubMed
29.
Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, Clegg LX: Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol. 1997, 146: 483-94.CrossRefPubMed
30.
O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999, 340: 14-22. 10.1056/NEJM199901073400103.CrossRefPubMed
31.
Iglesias del Sol A, Bots ML, Grobbee DE, Hofman A, Witteman JC: Carotid intima-media thickness at different sites: relation to incident myocardial infarction; The Rotterdam Study. Eur Heart J. 2002, 23: 934-40. 10.1053/euhj.2001.2965.CrossRefPubMed
32.
Rosvall M, Janzon L, Berglund G, Engström G, Hedblad B: Incident coronary events and case fatality in relation to common carotid intima-media thickness. J Intern Med. 2005, 257: 430-37. 10.1111/j.1365-2796.2005.01485.x.CrossRefPubMed
33.
Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M: Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006, 37: 87-92.CrossRefPubMed
34.
Djaberi R, Schuijf JD, de Koning EJ, Rabelink TJ, Smit JW, Kroft LJM, Pereira AM, Scholte AJ, Spaans M, Romijn JA, de Roos A, van der Wall EE, Wouter Jukema J, Bax JJ: Usefulness of carotid intima-media thickness in patients with diabetes mellitus as a predictor of coronary artery disease. Am J Cardiol. 2009, 104: 1041-1046. 10.1016/j.amjcard.2009.06.004.CrossRefPubMed
35.
Ito H, Komatsu Y, Mifune M, Antoku S, Ishida H, Takeuchi Y, Togane M: The estimated GFR, but not the stage of diabetic nephropathy graded by the urinary albumin excretion, is associated with the carotid intimamedia thickness in patients with type 2 diabetes mellitus: a crosssectional study. Cardiovasc Diabetol. 2010, 9: 18-10.1186/1475-2840-9-18.PubMedCentralCrossRefPubMed
36.
Escobedo J, Schargrodsky H, Champagne B, Silva H, Boissonnet CP, Vinueza R, Torres M, Hernandez R, Wilson E: Prevalence of metabolic syndrome in Latin America and its association with sub-clinical carotid atherosclerosis: the CARMELA cross-sectional study. Cardiovasc Diabetol. 2009, 8: 52-10.1186/1475-2840-8-52.PubMedCentralCrossRefPubMed
37.
Poppe KK, Whalley GA, Somaratne JB, Keelan S, Bagg W, Triggs CM, Doughty RN: The role of echocardiographic left ventricular mass and carotid intima-media thickness in the cardiovascular risk assessment of asymptomatic patients with type 2 diabetes mellitus. Intern Med J. 2010
38.
Einarson TR, Hunchuck J, Hemels M: Relationship between blood glucose and carotid intima media thickness: A meta-analysis. Cardiovasc Diabetol. 2010, 9: 37-10.1186/1475-2840-9-37.PubMedCentralCrossRefPubMed
Metadata
Title
Heart-Type Fatty Acid Binding Protein (H-FABP): Relationship with arterial ıntima-media thickness and role as diagnostic marker for atherosclerosis in patients with ımpaired glucose metabolism
Authors
Basak Karbek
Mustafa Özbek
Nujen Colak Bozkurt
Zeynep Ginis
Askın Güngünes
İlknur Öztürk Ünsal
Erman Cakal
Tuncay Delibası
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2011
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/1475-2840-10-37

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