Skip to main content
Top
Published in: BMC Health Services Research 1/2011

Open Access 01-12-2011 | Research article

Economic burden of illness of acute coronary syndromes: medical and productivity costs

Authors: Zhenxiang Zhao, Melissa Winget

Published in: BMC Health Services Research | Issue 1/2011

Login to get access

Abstract

Background

The significant economic burden associated with acute coronary syndromes (ACS) provides a need to evaluate both medical costs and productivity costs, according to evolving guideline-driven ACS treatment strategies, medical management (MM), percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG).

Methods

Commercially insured individuals, aged 18-64, with an emergency room (ER) visit or hospitalization accompanied by an ACS diagnosis (index event) were identified from a large claims database between 01/2004 and 12/2005 with a 1-year follow-up period. Patients who had an ACS diagnosis in the 12 months prior to their index event were excluded. Patients were divided into 3 groups according to treatment strategies during the index event: MM, PCI, or CABG. A subset of patients was identified for the productivity cost analysis exploring short-term disability and absenteeism costs. Multivariate generalized linear models were performed to examine the ACS costs by 3 different treatment strategies.

Results

A total of 10,487 patients were identified for the medical cost analysis. The total 1-year medical costs (index event costs plus the 1-year follow-up costs) were lowest for MM patients ($34,087), followed by PCI patients ($52,673) and CABG patients ($86,914). Of the 3,080 patients in the productivity costs analysis, 2,454 patients were identified in the short-term disability cohort and 626 patients were identified in the absenteeism cohort. Both the estimated mean total 1-year short-term disability and absenteeism costs were highest for CABG patients ($17,335, $14,960, respectively) compared to MM patients ($6,048, $9,826, respectively) and PCI patients ($9,221, $9,460, respectively).

Conclusions

Both total 1-year medical costs and 1-year productivity costs are substantial for working-aged individuals with ACS. These costs differ according to the type of treatment strategy, with CABG having higher costs compared to either PCI or MM.
Appendix
Available only for authorised users
Literature
1.
go back to reference Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J, on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation. 2010, 23 (7): e46-e215. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J, on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation. 2010, 23 (7): e46-e215.
2.
go back to reference Kolansky DM: Acute coronary syndromes: morbidity, mortality, and pharmacoeconomic burden. Am J Manag Care. 2009, 15: S36-S41.PubMed Kolansky DM: Acute coronary syndromes: morbidity, mortality, and pharmacoeconomic burden. Am J Manag Care. 2009, 15: S36-S41.PubMed
3.
go back to reference Turpie AG: Burden of disease: medical and economic impact of acute coronary syndromes. Am J Manag Care. 2006, 12: S430-S434.PubMed Turpie AG: Burden of disease: medical and economic impact of acute coronary syndromes. Am J Manag Care. 2006, 12: S430-S434.PubMed
4.
go back to reference Etemad LR, McCollam PL: Total first-year costs of acute coronary syndrome in a managed care setting. J Manage Care Pharm. 2005, 11 (4): 300-306. Etemad LR, McCollam PL: Total first-year costs of acute coronary syndrome in a managed care setting. J Manage Care Pharm. 2005, 11 (4): 300-306.
5.
go back to reference McCollam P, Etemad L: Cost of care for new-onset acute coronary syndrome patients who undergo coronary revascularization. J Invasive Cardiol. 2005, 17 (6): 307-311.PubMed McCollam P, Etemad L: Cost of care for new-onset acute coronary syndrome patients who undergo coronary revascularization. J Invasive Cardiol. 2005, 17 (6): 307-311.PubMed
6.
go back to reference Menzin J, Wygant G, Hauch O, Jacket J, Friedman M: One-year costs of ischemic heart disease among patients with acute coronary syndromes: findings from a multi-employer claims database. Curr Med Res Opin. 2008, 24 (2): 461-468. 10.1185/030079908X261096.CrossRefPubMed Menzin J, Wygant G, Hauch O, Jacket J, Friedman M: One-year costs of ischemic heart disease among patients with acute coronary syndromes: findings from a multi-employer claims database. Curr Med Res Opin. 2008, 24 (2): 461-468. 10.1185/030079908X261096.CrossRefPubMed
7.
go back to reference Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jur, Chavey WE II, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS: ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction). Circulation. 2007, 116 (7): 803-877. 10.1161/CIRCULATIONAHA.107.185752.CrossRef Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jur, Chavey WE II, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS: ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction). Circulation. 2007, 116 (7): 803-877. 10.1161/CIRCULATIONAHA.107.185752.CrossRef
8.
go back to reference Kushner FG, Hand M, Smith SC, King SB, Anderson JL, Antman EM, Bailey SR, Bates ER, Blankenship JC, Casey DE Jr, Green LA, Hochman JS, Jacobs AK, Krumholz HM, Morrison DA, Ornato JP, Pearle DL, Peterson ED, Sloan MA, Whitlow PL, Williams DO: 2009 Focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2009, 120 (22): 2271-2306. 10.1161/CIRCULATIONAHA.109.192663.CrossRefPubMed Kushner FG, Hand M, Smith SC, King SB, Anderson JL, Antman EM, Bailey SR, Bates ER, Blankenship JC, Casey DE Jr, Green LA, Hochman JS, Jacobs AK, Krumholz HM, Morrison DA, Ornato JP, Pearle DL, Peterson ED, Sloan MA, Whitlow PL, Williams DO: 2009 Focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2009, 120 (22): 2271-2306. 10.1161/CIRCULATIONAHA.109.192663.CrossRefPubMed
9.
go back to reference Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK, Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators: Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001, 345 (7): 494-502. 10.1056/NEJMoa010746.CrossRefPubMed Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK, Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators: Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001, 345 (7): 494-502. 10.1056/NEJMoa010746.CrossRefPubMed
10.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie : A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987, 40 (5): 373-383. 10.1016/0021-9681(87)90171-8.CrossRefPubMed Charlson ME, Pompei P, Ales KL, MacKenzie : A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987, 40 (5): 373-383. 10.1016/0021-9681(87)90171-8.CrossRefPubMed
11.
go back to reference Goetzel RZ, Hawkins K, Ozminkowski RJ, Wang S: The health and productivity cost burden of the "top 10" physical and mental health conditions affecting six large U.S. employers in 1999. J Occup Environ Med. 2003, 45 (1): 5-14. 10.1097/00043764-200301000-00007.CrossRefPubMed Goetzel RZ, Hawkins K, Ozminkowski RJ, Wang S: The health and productivity cost burden of the "top 10" physical and mental health conditions affecting six large U.S. employers in 1999. J Occup Environ Med. 2003, 45 (1): 5-14. 10.1097/00043764-200301000-00007.CrossRefPubMed
12.
go back to reference Manning WG, Mullahy J: Estimating Log Models: To Transform or Not to Transform?. J Health Econ. 2001, 20 (4): 461-494. 10.1016/S0167-6296(01)00086-8.CrossRefPubMed Manning WG, Mullahy J: Estimating Log Models: To Transform or Not to Transform?. J Health Econ. 2001, 20 (4): 461-494. 10.1016/S0167-6296(01)00086-8.CrossRefPubMed
13.
go back to reference McCullagh P, Nelder JA: Generalized linear models. 1989, London: Chapman and Hall, 2CrossRef McCullagh P, Nelder JA: Generalized linear models. 1989, London: Chapman and Hall, 2CrossRef
14.
go back to reference Manning WG: Dealing with skewed data on costs and expenditures. The Elgar Companion to Health Economics. Edited by: Jones A. 2006, 439-446. (Cheltenham, UK, Edward Elgar) Manning WG: Dealing with skewed data on costs and expenditures. The Elgar Companion to Health Economics. Edited by: Jones A. 2006, 439-446. (Cheltenham, UK, Edward Elgar)
15.
go back to reference Blough D, Ramsey S: Using Generalized Linear Models to Assess Medical Care Costs. Health Services & Outcomes Research Methodology. 2000, 1 (2): 185-202.CrossRef Blough D, Ramsey S: Using Generalized Linear Models to Assess Medical Care Costs. Health Services & Outcomes Research Methodology. 2000, 1 (2): 185-202.CrossRef
16.
go back to reference Jencks SF, Wilensky GR: The health care quality improvement initiative: a new approach to quality assurance in Medicare. JAMA. 1992, 268 (7): 900-903. 10.1001/jama.268.7.900.CrossRefPubMed Jencks SF, Wilensky GR: The health care quality improvement initiative: a new approach to quality assurance in Medicare. JAMA. 1992, 268 (7): 900-903. 10.1001/jama.268.7.900.CrossRefPubMed
17.
go back to reference Fox KA, Steg PG, Eagle KA, Goodman SG, Anderson FA, Granger CB, Flather MD, Budaj A, Quill A, Gore JM: Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. JAMA. 2007, 297: 1892-1900. 10.1001/jama.297.17.1892.CrossRefPubMed Fox KA, Steg PG, Eagle KA, Goodman SG, Anderson FA, Granger CB, Flather MD, Budaj A, Quill A, Gore JM: Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. JAMA. 2007, 297: 1892-1900. 10.1001/jama.297.17.1892.CrossRefPubMed
18.
go back to reference Krumholz HM, Wang Y, Chen J, Drye EE, Spertus JA, Ross JS, Curtis JP, Nallamothu BK, Lichtman JH, Havranek EP, Masoudi FA, Radford MJ, Han LF, Rapp MT, Straube BM, Normand SL: Reduction in acute myocardial infarction mortality in the united states: risk-standardized mortality rates from 1995-2006. JAMA. 2009, 302: 767-773. 10.1001/jama.2009.1178.CrossRefPubMedPubMedCentral Krumholz HM, Wang Y, Chen J, Drye EE, Spertus JA, Ross JS, Curtis JP, Nallamothu BK, Lichtman JH, Havranek EP, Masoudi FA, Radford MJ, Han LF, Rapp MT, Straube BM, Normand SL: Reduction in acute myocardial infarction mortality in the united states: risk-standardized mortality rates from 1995-2006. JAMA. 2009, 302: 767-773. 10.1001/jama.2009.1178.CrossRefPubMedPubMedCentral
19.
go back to reference Amsterdam EA, Peterson ED, Newby LK, Pollack CV, Gibler WB, Ohman EM, Roe MT: Comparative trends in guidelines adherence among patients with non-ST-segment elevation acute coronary syndromes treated with invasive versus conservative management strategies: Results from the CRUSADE quality improvement initiative. Am Heart J. 2009, 158: 748-754. 10.1016/j.ahj.2009.09.008.CrossRefPubMed Amsterdam EA, Peterson ED, Newby LK, Pollack CV, Gibler WB, Ohman EM, Roe MT: Comparative trends in guidelines adherence among patients with non-ST-segment elevation acute coronary syndromes treated with invasive versus conservative management strategies: Results from the CRUSADE quality improvement initiative. Am Heart J. 2009, 158: 748-754. 10.1016/j.ahj.2009.09.008.CrossRefPubMed
Metadata
Title
Economic burden of illness of acute coronary syndromes: medical and productivity costs
Authors
Zhenxiang Zhao
Melissa Winget
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2011
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/1472-6963-11-35

Other articles of this Issue 1/2011

BMC Health Services Research 1/2011 Go to the issue