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BMC Clinical Pharmacology
Published in: BMC Clinical Pharmacology 1/2012

Open Access 01-12-2012 | Research article

Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

Authors: Howard A Smithline, Michael Donnino, David J Greenblatt

Published in: BMC Clinical Pharmacology | Issue 1/2012

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Abstract

Background

High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects.

Methods

This was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures were calculated.

Results

The AUC0-10 hr and Cmax values increased nonlinearly between100 mg and 1500 mg. The slope of the AUC0-10 hr vs dose, as well as the Cmax vs dose, plots are steepest at the lowest thiamine doses.

Conclusion

Our study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process.

Trial Registration

ClinicalTrials.gov: NCT00981877
Appendix
Available only for authorised users
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Metadata
Title
Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects
Authors
Howard A Smithline
Michael Donnino
David J Greenblatt
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Clinical Pharmacology / Issue 1/2012
Electronic ISSN: 1472-6904
DOI
https://doi.org/10.1186/1472-6904-12-4

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