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BMC Clinical Pathology
Published in: BMC Clinical Pathology 1/2013

Open Access 01-12-2013 | Case report

Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature

Authors: Maryam Maghbool, Mani Ramzi, Inga Nagel, Pablo Bejarano, Reiner Siebert, Abolfazl Saeedzadeh, Yahya Daneshbod

Published in: BMC Clinical Pathology | Issue 1/2013

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Abstract

Background

Primary adenocarcinoma of thymus is extremely rare.

Case presentation

This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32.

Conclusion

This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors.
Appendix
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Metadata
Title
Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature
Authors
Maryam Maghbool
Mani Ramzi
Inga Nagel
Pablo Bejarano
Reiner Siebert
Abolfazl Saeedzadeh
Yahya Daneshbod
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Clinical Pathology / Issue 1/2013
Electronic ISSN: 1472-6890
DOI
https://doi.org/10.1186/1472-6890-13-17

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