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BMC Complementary Medicine and Therapies

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Open Access 01-12-2014 | Research article

Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water

Authors: Jinling Xue, Guodong Shang, Yoshinori Tanaka, Yasuhiro Saihara, Lingyan Hou, Natalia Velasquez, Wenjun Liu, Yun Lu

Published in: BMC Complementary Medicine and Therapies | Issue 1/2014

Abstract

Background

Hydrogen has been reported to relieve damage in many disease models, and is a potential additive in drinking water to provide protective effects for patients as several clinical studies revealed. However, the absence of a dose–response relationship in the application of hydrogen is puzzling. We attempted to identify the dose–response relationship of hydrogen in alkaline electrolyzed drinking water through the aspirin induced gastric injury model.

Methods

In this study, hydrogen-rich alkaline water was obtained by adding H₂ to electrolyzed water at one atmosphere pressure. After 2 weeks of drinking, we detected the gastric mucosal damage together with MPO, MDA and 8-OHdG in rat aspirin induced gastric injury model.

Results

Hydrogen-dose dependent inhibition was observed in stomach mucosal. Under pH 8.5, 0.07, 0.22 and 0.84 ppm hydrogen exhibited a high correlation with inhibitory effects showed by erosion area, MPO activity and MDA content in the stomach. Gastric histology also demonstrated the inhibition of damage by hydrogen-rich alkaline water. However, 8-OHdG level in serum did not have significant hydrogen-dose dependent effect. pH 9.5 showed higher but not significant inhibitory response compared with pH 8.5.

Conclusions

Hydrogen is effective in relieving the gastric injury induced by aspirin-HCl, and the inhibitory effect is dose-dependent. The reason behind this may be that hydrogen-rich water directly interacted with the target tissue, while the hydrogen concentration in blood was buffered by liver glycogen, evoking a suppressed dose–response effect. Drinking hydrogen-rich water may protect healthy individuals from gastric damage caused by oxidative stress.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/14/81/prepub

Title: Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water
Authors: Jinling Xue
Guodong Shang
Yoshinori Tanaka
Yasuhiro Saihara
Lingyan Hou
Natalia Velasquez
Wenjun Liu
Yun Lu
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Complementary Medicine and Therapies / Issue 1/2014
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/1472-6882-14-81

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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