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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2013

Open Access 01-12-2013 | Research article

In vitro anticancer screening of 24 locally used Nigerian medicinal plants

Authors: Saudat Adamson Fadeyi, Olugbeminiyi O Fadeyi, Adedeji A Adejumo, Cosmas Okoro, Elbert Lewis Myles

Published in: BMC Complementary Medicine and Therapies | Issue 1/2013

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Abstract

Background

Plants that are used as traditional medicine represent a relevant pool for selecting plant candidates that may have anticancer properties. In this study, the ethnomedicinal approach was used to select several medicinal plants native to Nigeria, on the basis of their local or traditional uses. The collected plants were then evaluated for cytoxicity.

Methods

The antitumor activity of methanolic extracts obtained from 24 of the selected plants, were evaluated in vitro on five human cancer cell lines.

Results

Results obtained from the plants screened indicate that 18 plant extracts of folk medicine exhibited promising cytotoxic activity against human carcinoma cell lines. Erythrophleum suaveolens (Guill. & Perr.) Brenan was found to demonstrate potent anti-cancer activity in this study exhibiting IC50 = 0.2-1.3 μg/ml.

Conclusions

Based on the significantly potent activity of some plants extracts reported here, further studies aimed at mechanism elucidation and bio-guided isolation of active anticancer compounds is currently underway.
Appendix
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Metadata
Title
In vitro anticancer screening of 24 locally used Nigerian medicinal plants
Authors
Saudat Adamson Fadeyi
Olugbeminiyi O Fadeyi
Adedeji A Adejumo
Cosmas Okoro
Elbert Lewis Myles
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2013
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/1472-6882-13-79

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