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BMC Complementary Medicine and Therapies

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Open Access 01-12-2012 | Research article

The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats

Authors: Hui Chen, Jun Yin, Yanpin Deng, Min Yang, Lingling Xu, Fukang Teng, Defang Li, Yufan Cheng, Sha Liu, Dong Wang, Tingting Zhang, Wanying Wu, Xuan Liu, Shuhong Guan, Baohong Jiang, Dean Guo

Published in: BMC Complementary Medicine and Therapies | Issue 1/2012

Abstract

Background

Although a number of medicines are available for the management of hypertension, the organ damage induced by hypertension is not resolved. The aim of this study was to investigate the protection of ginsenoside Rg1 (Rg1) against vascular remodeling and organ damage in spontaneously hypertensive rats (SHR).

Methods

Male SHR were treated with 5, 10 or 20 mg/kg Rg1 through intraperitoneal injection per day for 1 month. SHR or Wistar-Kyoto rats (WKY) receiving vehicle (saline) was used as control. Blood pressure detection and pathological stain, transmission electron microscope, immunohistochemical assay were used to elucidate the protection of Rg1.

Results

Blood pressures were not different between control SHR rats and Rg1 treated SHR rats, but Rg1 improved the aortic outward remodeling by lowering the lumen diameter and reducing the media thickness according the histopathological and ultrastructural detections. Rg1 also protected the retinal vessels against inward remodeling detected by immunohistochemical assay. Furthermore, Rg1 attenuated the target heart and kidney damage with improvement on cardiac and glomerular structure.

Conclusions

These results suggested that Rg1 held beneficial effects on vascular structure and further protected against the organ-damage induced by hypertension. These findings also paved a novel and promising approach to the treatment of hypertensive complications.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/12/53/prepub

Title: The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats
Authors: Hui Chen
Jun Yin
Yanpin Deng
Min Yang
Lingling Xu
Fukang Teng
Defang Li
Yufan Cheng
Sha Liu
Dong Wang
Tingting Zhang
Wanying Wu
Xuan Liu
Shuhong Guan
Baohong Jiang
Dean Guo
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Complementary Medicine and Therapies / Issue 1/2012
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/1472-6882-12-53

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The protective effects of ginsenoside Rg1 against hypertension target-organ damage in spontaneously hypertensive rats

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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