Published in:
Open Access 01-12-2011 | Research article
RETRACTED ARTICLE: In vitro antioxidant and anticancer activity of young Zingiber officinale against human breast carcinoma cell lines
Published in: BMC Complementary Medicine and Therapies | Issue 1/2011
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Background
Ginger is one of the most important spice crops and traditionally has been
used as medicinal plant in Bangladesh. The present work is aimed to find out
antioxidant and anticancer activities of two Bangladeshi ginger varieties
(Fulbaria and Syedpuri) at young age grown under ambient (400 μmol/mol) and
elevated (800 μmol/mol) CO2 concentrations against two
human breast cancer cell lines (MCF-7 and MDA-MB-231).
Methods
The effects of ginger on MCF-7 and MDA-MB-231 cell lines were determined using
TBA (thiobarbituric acid) and MTT
[3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assays.
Reversed-phase HPLC was used to assay flavonoids composition among Fulbaria and
Syedpuri ginger varieties grown under increasing CO2
concentration from 400 to 800 μmol/mol.
Results
Antioxidant activities in both varieties found increased significantly (P ≤
0.05) with increasing CO2 concentration from 400 to 800
μmol/mol. High antioxidant activities were observed in the rhizomes of Syedpuri
grown under elevated CO2 concentration. The results showed
that enriched ginger extract (rhizomes) exhibited the highest anticancer activity
on MCF-7 cancer cells with IC50 values of 34.8 and 25.7
μg/ml for Fulbaria and Syedpuri respectively. IC50 values
for MDA-MB-231 exhibition were 32.53 and 30.20 μg/ml for rhizomes extract of
Fulbaria and Syedpuri accordingly.
Conclusions
Fulbaria and Syedpuri possess antioxidant and anticancer properties especially
when grown under elevated CO2 concentration. The use of
ginger grown under elevated CO2 concentration may have
potential in the treatment and prevention of cancer.