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Open Access 01-12-2014 | Research article

The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors

Authors: Denise Tostes Oliveira, Laís Priscila de Santis, Agnes Assao, Kellen Cristine Tjioe, Suely Nonogaki, José Roberto Pereira Lauris, Fernando Augusto Soares

Published in: BMC Oral Health | Issue 1/2014

Abstract

Background

The aims of this study were to investigate the immunolocalization of ezrin and its relationship with the podoplanin expression in keratocystic odontogenic tumors.

Material and Methods

The immunohistochemical expressions of ezrin and podoplanin by odontogenic epithelium were evaluated in keratocystic odontogenic tumors using monoclonal antibodies.

Results

Our results showed strong cytoplasmic ezrin and membranous podoplanin expressions in basal epithelial layer of all keratocystic odontogenic tumors. The cytoplasmic and membranous ezrin expressions were also detected in suprabasal epithelial layers of tumors. Statistically significant difference between cellular immunolocalization of ezrin and podoplanin odontogenic epithelium were found by Wilcoxon’s test (p < 0.05). No correlation between both proteins in keratocystic odontogenic tumors was detected by Spearman test.

Conclusions

These results suggest that ezrin and podoplanin may contribute to the expansive growth and local invasiveness of keratocystic odontogenic tumors. Additionally, as both proteins were overexpressed by odontogenic epithelium, their possible roles need to be further explored in benign odontogenic tumors.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6831/14/150/prepub

Title: The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors
Authors: Denise Tostes Oliveira
Laís Priscila de Santis
Agnes Assao
Kellen Cristine Tjioe
Suely Nonogaki
José Roberto Pereira Lauris
Fernando Augusto Soares
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Oral Health / Issue 1/2014
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/1472-6831-14-150

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The relationship between ezrin and podoplanin expressions in keratocystic odontogenic tumors

Abstract

Background

Material and Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Material and Methods

Results

Conclusions

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