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BMC Dermatology
Published in: BMC Dermatology 1/2009

Open Access 01-12-2009 | Research article

A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay

Authors: Jorg Heukelbach, André Asenov, Oliver Liesenfeld, Ali Mirmohammadsadegh, Fabíola A Oliveira

Published in: BMC Dermatology | Issue 1/2009

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Abstract

Background

Dimeticones kill head lice by physical means. Here we assessed in a comparative bioassay the ex vivo efficacy of "NYDA® sensitiv", a new two-phase dimeticone-based pediculicide similar to a product established on the market, but without fragrances.

Methods

We compared efficacy of the new product to a positive dimeticone control group, a sample of four other insecticidal and natural head lice products marketed in Germany, and an untreated control. In a bioassay, lice were exposed ex vivo to products and examined for activity for up to 24 hours, following a standard protocol.

Results

After 6 and 24 hours, 13.7 and 88.5% of untreated control lice did not show major vital signs. In contrast, no lice showed major vital signs 5 minutes after treatment with the new product or the control dimeticone group (NYDA®). This effect persisted at all observation points (100% efficacy). Efficacy of 0.5% permethrin (Infectopedicul®) ranged between 76 and 96% in evaluations between 5 min and 6 hours. All lice treated with a coconut-based compound (mosquito® Läuseshampoo) did not show major vital signs after 5 min, but mortality was only 58% after one hour. Pyrethrum extract (Goldgeist® forte) showed an efficacy of 22 - 52% between 5 min and 3 hours after treatment; after 6 hours, 76% of lice were judged dead. An oxyphthirine®-based compound (Liberalice DUO LP-PRO®) killed 22 - 54% of lice in the first 6 hours.

Conclusions

The two-phase dimeticone compound NYDA® sensitiv is highly efficacious. The removal of fragrances as compared to an established dimeticone product did not affect in vitro efficacy.
Appendix
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Metadata
Title
A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay
Authors
Jorg Heukelbach
André Asenov
Oliver Liesenfeld
Ali Mirmohammadsadegh
Fabíola A Oliveira
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Dermatology / Issue 1/2009
Electronic ISSN: 1471-5945
DOI
https://doi.org/10.1186/1471-5945-9-12

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