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BMC Urology
Published in: BMC Urology 1/2007

Open Access 01-12-2007 | Research article

Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study

Authors: Joan Fortuny, Manolis Kogevinas, Michael S Zens, Alan Schned, Angeline S Andrew, John Heaney, Karl T Kelsey, Margaret R Karagas

Published in: BMC Urology | Issue 1/2007

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Abstract

Background

Use of phenacetin and other analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) potentially influences bladder cancer incidence, but epidemiologic evidence is limited.

Methods

We analyzed data from 376 incident bladder cancer cases and 463 controls from a population-based case-control study in New Hampshire on whom regular use of analgesic drugs and NSAIDs was obtained. Odds ratios and 95% confidence intervals were computed using logistic regression with adjustment for potentially confounding factors. Separate models by tumor stage, grade and TP53 status were conducted.

Results

We found an elevated odds ratio (OR) associated with reported use of phenacetin-containing medications, especially with longer duration of use (OR >8 years = 3.00, 95% confidence interval (CI) = 1.4–6.5). In contrast, use of paracetamol did not relate overall to risk of bladder cancer. We also found that regular use of any NSAID was associated with a statistically significant decrease in bladder cancer risk (OR = 0.6, 95% CI = 0.4–0.9), and specifically use of aspirin. Further, the association with NSAID use was largely among invasive, high grade and TP53 positive tumors.

Conclusion

While these agents have been investigated in several studies, a number of questions remain regarding the effects of analgesic and NSAID use on risk of bladder cancer.
Appendix
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Metadata
Title
Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study
Authors
Joan Fortuny
Manolis Kogevinas
Michael S Zens
Alan Schned
Angeline S Andrew
John Heaney
Karl T Kelsey
Margaret R Karagas
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2007
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/1471-2490-7-13

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