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BMC Musculoskeletal Disorders

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Open Access 01-12-2014 | Research article

Elevated VEGF levels contribute to the pathogenesis of osteoarthritis

Authors: Quan Yuan, Li Sun, Jian-Jun Li, Chun-Hou An

Published in: BMC Musculoskeletal Disorders | Issue 1/2014

Abstract

Background

The aim of our meta-analysis is to understand the relationship between the pathogenesis of osteoarthritis and the expression levels of vascular endothelial growth factor (VEGF) in multiple disease tissues in osteoarthritis patients.

Methods

The following electronic databases were searched, without language restrictions, to retrieve published studies relevant to VEGF and osteoarthritis: MEDLINE (1966 ~ 2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), Web of Science (1945 ~ 2013) and the Chinese Biomedical Database (CBM) (1982 ~ 2013). Meta-analysis of the extracted data was performed using the STATA statistical software. Standardized mean difference (SMD) with its corresponding 95% confidence interval (95% CI) was calculated.

Results

A total of 11 case–control studies, containing 302 osteoarthritis patients and 195 healthy controls, met our selection criteria for this meta-analysis. Our analyses of the data available from multiple disease tissues demonstrate that VEGF expression levels in osteoarthritis patients are significantly higher than healthy controls (SMD = 1.18, 95% CI: 4.91 ~ 9.11, P < 0.001). A subgroup analysis based on ethnicity revealed that both Asian and Caucasian osteoarthritis patients had higher levels of VEGF expression compared to their respective healthy counterparts (Asians: SMD = 5.49, 95% CI: 3.44 ~ 7.54, P < 0.001; Caucasians: SMD = 15.17, 95% CI: 5.21 ~ 25.13, P = 0.003; respectively). We also performed other subgroup analyses based on country, language and sample source, and the results showed that, in all these subgroups, osteoarthritis patients had higher levels of VEGF expression than healthy controls (all P > 0.05).

Conclusion

Our meta-analysis provides evidence that higher VEGF expression levels strongly correlate with the pathogenesis of osteoarthritis.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2474/15/437/prepub

Title: Elevated VEGF levels contribute to the pathogenesis of osteoarthritis
Authors: Quan Yuan
Li Sun
Jian-Jun Li
Chun-Hou An
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Musculoskeletal Disorders / Issue 1/2014
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/1471-2474-15-437

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Elevated VEGF levels contribute to the pathogenesis of osteoarthritis

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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