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Open Access 01-12-2014 | Research article

Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study

Authors: Chun-Hua Wang, Pai-Chien Chou, Wen-Ching Joa, Li-Fei Chen, Te-Fang Sheng, Shu-Chuan Ho, Horng-Chyuan Lin, Chien-Da Huang, Fu-Tsai Chung, Kian Fan Chung, Han-Pin Kuo

Published in: BMC Pulmonary Medicine | Issue 1/2014

Abstract

Background

Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients.

Methods

To investigate whether the home-based exercise training program can reduce inflammatory biomarkers in patients with COPD, twelve patients using mobile phone assistance and 14 with free walk were assessed by incremental shuttle walk test (ISWT), spirometry, strength of limb muscles, and serum C-reactive protein (CRP) and inflammatory cytokines.

Results

Patients in the mobile phone group improved their ISWT walking distance, with decrease in serum CRP after 2 months, and sustained at 6 months. Patients in the control group had no improvement. Serum IL-8 in the mobile phone group was significantly reduced at 2, 3 and 6 months after doing home exercise training compared to baseline. IL-6 and TNF-α were significantly elevated at 3 and 6 months in control group, while there were no changes in mobile phone group. The strength of limb muscles was significantly greater compared to baseline at 3 and 6 months in the mobile phone group.

Conclusions

A mobile-phone-based system can provide an efficient home endurance exercise training program with improved exercise capacity, strength of limb muscles and a decrease in serum CRP and IL-8 in COPD patients. Decreased systemic inflammation may contribute to these clinical benefits. (Clinical trial registration No.: NCT01631019)

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2466/14/142/prepub

Title: Mobile-phone-based home exercise training program decreases systemic inflammation in COPD: a pilot study
Authors: Chun-Hua Wang
Pai-Chien Chou
Wen-Ching Joa
Li-Fei Chen
Te-Fang Sheng
Shu-Chuan Ho
Horng-Chyuan Lin
Chien-Da Huang
Fu-Tsai Chung
Kian Fan Chung
Han-Pin Kuo
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Pulmonary Medicine / Issue 1/2014
Electronic ISSN: 1471-2466
DOI: https://doi.org/10.1186/1471-2466-14-142

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