Top

Published in:

Open Access 01-12-2012 | Research article

Does treatment adherence correlates with health related quality of life? findings from a cross sectional study

Authors: Fahad Saleem, Mohamed Azmi Hassali, Asrul Akmal Shafie, George A Awad, Muhammad Atif, Noman ul Haq, Hisham Aljadhey, Maryam Farooqui

Published in: BMC Public Health | Issue 1/2012

Abstract

Background

Although medication adherence and health-related quality of life (HRQoL) are two different outcome measures, it is believed that adherence to medication leads to an improvement in overall HRQoL. The study aimed to evaluate the association between medication adherence and HRQoL.

Methods

A questionnaire-based cross-sectional study design was undertaken with hypertension patients attending public hospitals in Quetta city, Pakistan. HRQoL was measured by Euroqol EQ-5D. Medication adherence was assessed by the Drug Attitude Inventory. Descriptive statistics was used to tabulate demographic and disease-related information. Spearmans correlation was used to assess the association between the study variables. All analysis was performed using SPSS 17.0.

Results

Among 385 study patients, the mean age (SD) was 39.02 (6.59), with 68.8% of males dominating the entire cohort. The mean (SD) duration of hypertension was 3.010.939years. Forty percent (n=154) had a bachelors degree level of education with 34.8% (n=134) working in the private sector. A negative and weak correlation (0.77) between medication adherence and EQ-5D was reported. In addition, a negative weak correlation (0.120) was observed among medication adherence and EQ-VAS.

Conclusions

Correlations among the study variables were negligible and negative. Hence, there is no apparent relationship between the variables.

Côté I, Farris K, Feeny D: Is adherence to drug treatment correlated with health-related quality of life?. Qual of Life Res. 2003, 12: 621-633. 10.1023/A:1025180524614.CrossRef

Saleem F, Hassali MA, Shafie AA, Awad AG, Bashir S: Association between Knowledge and Drug Adherence in Patients with Hypertension in Quetta, Pakistan. Trop J Pharm Res. 2011, 10: 125-132.

Saleem F, Hassali MA, Shafie AA: A cross-sectional assessment of health-related quality of life (HRQoL) among hypertensive patients in Pakistan. Health Expectations. 2012, 10.1111/j.1369-7625.2012.00765.x.

Green LW, Kreuter MW: Health program planning: An educational and ecological approach. 2005, McGraw-Hill Companies, 2

Bonomi AE, Patrick DL, Bushnell DM, Martin M: Validation of the United States' version of the World Health Organization Quality of Life (WHOQOL) instrument. J Clin Epidemiol. 2000, 53: 1-12. 10.1016/S0895-4356(99)00123-7.CrossRefPubMed

Martnez Y, Prado-Aguilar C, Rascn-Pacheco R, Valdivia-Martnez J: Quality of life associated with treatment adherence in patients with type 2 diabetes: a cross-sectional study. BMC Heal Serv Res. 2008, 8: 164-10.1186/1472-6963-8-164.CrossRef

Nunes MI: The relationship between quality of life and adherence to treatment. Curr Hypertens Reports. 2001, 3: 462-465. 10.1007/s11906-001-0007-9.CrossRef

Os I: Quality of life in hypertension. J Hum Hypertens. 1994, 8: S27-S30.PubMed

Leonetti G, Comerio G, Cuspidi C: Evaluating quality of life in hypertensive patients. J Cardiovasc Pharmacol. 1994, 23: S54-S58.CrossRefPubMed

10.

Trevisol DJ, Moreira LB, Kerkhoff A, Fuchs SC, Fuchs FD: Health-related quality of life and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens. 2011, 29: 179-88. 10.1097/HJH.0b013e328340d76f.CrossRefPubMed

11.

Korhonen PE, Kivelä SL, Kautiainen H, Järvenpää S, Kantola I: Health-related quality of life and awareness of hypertension. J Hypertens. 2011, 29: 2070-2074. 10.1097/HJH.0b013e32834bbca7.CrossRefPubMed

12.

Godley P, Pham H, Rohack J, Woodward B, Yokoyama K, Maue SK: Opportunities for improving the quality of hypertension care in a managed care setting. Am J Health Syst Pharm. 2001, 58: 1728-1733.PubMed

13.

Whitworth J: 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens. 2003, 21: 1983-1992.CrossRefPubMed

14.

Trevisol D, Moreira L, Fuchs F, Fuchs S: Health-related quality of life is worse in individuals with hypertension under drug treatment: results of population-based study. Journal of Human Hypertension. 2003, 10.1038/jhh.2011.48.

15.

Holt EW, Muntner P, Joyce CJ, Webber L, Krousel-Wood MA: Health-related quality of life and antihypertensive medication adherence among older adults. Age and Ageing. 2010, 39: 481-487. 10.1093/ageing/afq040.CrossRefPubMedPubMedCentral

16.

Pippalla R, Chinburapa V, Duval R, Akula R: Interrelationships of quality of life, compliance, clinical outcomes and life satisfaction: a crosssectional study on hypertensive geriatrics. J Clin Pharm Ther. 1997, 22: 357-369. 10.1111/j.1365-2710.1997.tb00019.x.CrossRefPubMed

17.

Trivedi RB, Ayotte B, Edelman D, Bosworth HB: The association of emotional well-being and marital status with treatment adherence among patients with hypertension. J Behav Med. 2008, 31: 489-497. 10.1007/s10865-008-9173-4.CrossRefPubMedPubMedCentral

18.

Coyne KS, Davis D, French F, Hill MN: Health-related quality of life in patients treated for hypertension: a review of the literature from 1990 to 2000. Clin Ther. 2002, 24: 142-169. 10.1016/S0149-2918(02)85012-3.CrossRefPubMed

19.

National Bioethics Committee Pakistan: Ethical Research Committee-Guidelines. 2011, [http://www.pmrc.org.pk/erc_guidelines.htm]

20.

National Health Survey of Pakistan 19901994: Research activites. 2011, [http://www.pmrc.org.pk/researchactivities.htm.]

21.

Daniel WW: Biostatistics: basic concepts and methodology for the health sciences. 2010, John Wiley & Sons, New York

22.

Voruganti L, Awad A: Neuroleptic dysphoria: towards a new synthesis. Psychopharmacology. 2004, 171: 121-132. 10.1007/s00213-003-1648-y.CrossRefPubMed

23.

Williams A: EuroQola new facility for the measurement of health-related quality of life. Health Policy. 1990, 16: 199-208.CrossRef

24.

Dolan P, University of York. Centre for Health Economics: A social tariff for EuroQol: results from a UK general population survey. 1995, Center for Health Economics, The University of York

25.

Kim JH, Kim SY, Ahn YM, Kim YS: Subjective response to clozapine and risperidone treatment in outpatients with schizophrenia. Progress in Neuro-Psychopharmacology and Bioll Psychiatry. 2006, 30: 301-305. 10.1016/j.pnpbp.2005.10.006.CrossRef

26.

Billups SJ, Malone DC, Carter BL: The relationship between drug therapy noncompliance and patient characteristics, health-related quality of life, and health care costs. Pharmacotherapy. 2000, 20: 941-949. 10.1592/phco.20.11.941.35266.CrossRefPubMed

27.

Sung J, Nichol MB, Venturini F, Bailey KL, McCombs JS, Cody M: Factors affecting patient compliance with antihyperlipidemic medications in an HMO population. Am J Managed Care. 1998, 4: 1421-1430.

28.

Carballo E, Cadarso-Surez C, Carrera I, Fraga J, De la Fuente J, Ocampo A, Ojea R, Prieto A: Assessing relationships between health-related quality of life and adherence to antiretroviral therapy. Qual Life Res. 2004, 13: 587-599.CrossRefPubMed

29.

Takemura M, Kobayashi M, Kimura K, Mitsui K, Masui H, Koyama M, Itotani R, Ishitoko M, Suzuki S, Aihara K: Repeated instruction on inhalation technique improves adherence to the therapeutic regimen in asthma. J Asthma. 2010, 47: 202-208. 10.3109/02770900903581692.CrossRefPubMed

30.

Bandura A: The Primacy of Self-Regulation in Health Promotion. Appl Psychol. 2005, 54: 245-254. 10.1111/j.1464-0597.2005.00208.x.CrossRef

31.

Osterberg L, Blaschke T: Adherence to medication. N Engl J Med. 2005, 353: 487-497. 10.1056/NEJMra050100.CrossRefPubMed

32.

Saarni SI, Härkänen T, Sintonen H, Suvisaari J, Koskinen S, Aromaa A, Lönnqvist J: The impact of 29 chronic conditions on health-related quality of life: a general population survey in Finland using 15D and EQ-5D. Qual Life Res. 2006, 15: 1403-1414. 10.1007/s11136-006-0020-1.CrossRefPubMed

33.

Croog SH, Levine S, Testa MA, Brown B, Bulpitt CJ, Jenkins CD, Klerman GL, Williams GH: The effects of antihypertensive therapy on the quality of life. N Engl J Med. 1986, 314: 1657-1664. 10.1056/NEJM198606263142602.CrossRefPubMed

34.

Jacob S, Rett K, Henriksen EJ: Antihypertensive therapy and insulin sensitivity: Do we have to redefine the role of -blocking agents?. Am J Hypertens. 1998, 11: 1258-1265. 10.1016/S0895-7061(98)00141-1.CrossRefPubMed

35.

Testa MA, Anderson RB, Nackley JF, Hollenberg NK: Quality of life and antihypertensive therapy in men-a comparison of captopril with enalapril. N Engl J Med. 1993, 328: 907-913. 10.1056/NEJM199304013281302.CrossRefPubMed

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/12/318/prepub

Title: Does treatment adherence correlates with health related quality of life? findings from a cross sectional study
Authors: Fahad Saleem
Mohamed Azmi Hassali
Asrul Akmal Shafie
George A Awad
Muhammad Atif
Noman ul Haq
Hisham Aljadhey
Maryam Farooqui
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2012
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/1471-2458-12-318

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Does treatment adherence correlates with health related quality of life? findings from a cross sectional study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2012

The DRUID study: racism and self-assessed health status in an indigenous population

Knowledge, attitudes and practices among people with chronic hepatitis B attending a hepatology clinic in Malaysia: A cross sectional study

Does the effect of gender modify the relationship between deprivation and mortality?

Sexual life and fertility desire in long-term HIV serodiscordant couples in Addis Ababa, Ethiopia: a grounded theory study

Understanding how adherence goals promote adherence behaviours: a repeated measure observational study with HIV seropositive patients

Acceptance patterns and decision-making for human papillomavirus vaccination among parents in Vietnam: an in-depth qualitative study post-vaccination