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Published in: BMC Public Health 1/2010

Open Access 01-12-2010 | Research article

Examining appropriate diagnosis and treatment of malaria: availability and use of rapid diagnostic tests and artemisinin-based combination therapy in public and private health facilities in south east Nigeria

Authors: Benjamin SC Uzochukwu, Lausdeus O Chiegboka, Chibuike Enwereuzo, Usonwanne Nwosu, David Okorafor, Obinna E Onwujekwe, Nkoli P Uguru, Florence T Sibeudu, Ogochukwu P Ezeoke

Published in: BMC Public Health | Issue 1/2010

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Abstract

Background

Rapid diagnostic tests (RDTs) and Artemisinin-based combination therapy (ACT) have been widely advocated by government and the international community as cost-effective tools for diagnosis and treatment of malaria. ACTs are now the first line treatment drug for malaria in Nigeria and RDTs have been introduced by the government to bridge the existing gaps in proper diagnosis. However, it is not known how readily available these RDTs and ACTs are in public and private health facilities and whether health workers are actually using them. Hence, this study investigated the levels of availability and use of RDTs and ACTs in these facilities.

Methods

The study was undertaken in Enugu state, southeast Nigeria in March 2009. Data was collected from heads of 74 public and private health facilities on the availability and use of RDTs and ACTs. Also, the availability of RDTs and the types of ACTs that were available in the facilities were documented.

Results

Only 31.1% of the health facilities used RDTs to diagnose malaria. The majority used the syndromic approach. However, 61.1% of healthcare providers were aware of RDTs. RDTs were available in 53.3% of the facilities. Public health facilities and health facilities in the urban areas were using RDTs more and these were mainly bought from pharmacy shops and supplied by NGOs. The main reasons given for non use are unreliability of RDTs, supply issues, costs, preference for other methods of diagnosis and providers' ignorance. ACTs were the drug of choice for most public health facilities and the drugs were readily available in these facilities.

Conclusion

Although many providers were knowledgeable about RDTs, not many facilities used it. ACTS were readily available and used in public but not private health facilities. However, the reported use of ACTs with limited proper diagnosis implies that there could be high incidence of inappropriate case management of malaria which can also increase the economic burden of illnesses. Government and donors should ensure constant availability of RDTs in both public and private facilities, so that every treatment with ACTs is accompanied with proper diagnosis.
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Literature
1.
go back to reference World Health Organization: The Africa Malaria Report 2006. 2006, World Health Organization, Geneva World Health Organization: The Africa Malaria Report 2006. 2006, World Health Organization, Geneva
2.
go back to reference Federal Ministry of Health (FMOH): Report of the malaria situation analysis survey conducted in the six zones of Nigeria. 2000, FMOH, Abuja, Nigeria Federal Ministry of Health (FMOH): Report of the malaria situation analysis survey conducted in the six zones of Nigeria. 2000, FMOH, Abuja, Nigeria
3.
go back to reference Federal Ministry of Health (FMOH): National Antimalarial Treatment Guidelines. 2005, National Malaria and Vector Control Division Abuja, Nigeria Federal Ministry of Health (FMOH): National Antimalarial Treatment Guidelines. 2005, National Malaria and Vector Control Division Abuja, Nigeria
4.
go back to reference World Health Organization: World Malaria Report 2008. 2008, World Health Organization, GenevaCrossRef World Health Organization: World Malaria Report 2008. 2008, World Health Organization, GenevaCrossRef
5.
go back to reference Jimoh A, Sofola O, Petu A, Okorosobo T: Quantifying the Economic Burden of Malaria in Nigeria Using the Willingness to Pay Approach. Cost Effectiveness and Resource Allocation. 2007, 5: 6-10.1186/1478-7547-5-6.CrossRefPubMedPubMedCentral Jimoh A, Sofola O, Petu A, Okorosobo T: Quantifying the Economic Burden of Malaria in Nigeria Using the Willingness to Pay Approach. Cost Effectiveness and Resource Allocation. 2007, 5: 6-10.1186/1478-7547-5-6.CrossRefPubMedPubMedCentral
6.
go back to reference Amexo M, Tolhurst R, Barnish G, Bates I: Malaria misdiagnosis: effects on the poor and vulnerable. Lancet. 2004, 364: 1896-8. 10.1016/S0140-6736(04)17446-1.CrossRefPubMed Amexo M, Tolhurst R, Barnish G, Bates I: Malaria misdiagnosis: effects on the poor and vulnerable. Lancet. 2004, 364: 1896-8. 10.1016/S0140-6736(04)17446-1.CrossRefPubMed
7.
go back to reference Zurovac D, Midia B, Ochola SA, English M, Snow RW: Microscopy and outpatient malaria case management among older children and adults in Kenya. Trop Med Int Health. 2006, 11: 432-440. 10.1111/j.1365-3156.2006.01587.x.CrossRefPubMed Zurovac D, Midia B, Ochola SA, English M, Snow RW: Microscopy and outpatient malaria case management among older children and adults in Kenya. Trop Med Int Health. 2006, 11: 432-440. 10.1111/j.1365-3156.2006.01587.x.CrossRefPubMed
8.
go back to reference Uneke CJ: Concurrent malaria and typhoid fever in the tropics: the diagnostic challenges and public health implications. Journal of Vector Borne Diseases. 2008, 45: 133-142.PubMed Uneke CJ: Concurrent malaria and typhoid fever in the tropics: the diagnostic challenges and public health implications. Journal of Vector Borne Diseases. 2008, 45: 133-142.PubMed
9.
go back to reference Nwachukwu C, Meremikwu M, Oringanje C: Evaluation of BID® Plasmodium Lactate Dehydrogenase (Pldh) Rapid Diagnostic Test (RDT) For Detection Of Malaria Parasite In Calabar, Nigeria. 2008, Publication of the Institute of Tropical Diseases Research and Prevention, Calabar, Nigeria Nwachukwu C, Meremikwu M, Oringanje C: Evaluation of BID® Plasmodium Lactate Dehydrogenase (Pldh) Rapid Diagnostic Test (RDT) For Detection Of Malaria Parasite In Calabar, Nigeria. 2008, Publication of the Institute of Tropical Diseases Research and Prevention, Calabar, Nigeria
10.
go back to reference Oguonu T, Okafor HU: Comparison of clinical, microscopic and rapid diagnostic test methods in the diagnosis of Plasmodium falciparum malaria in Enugu, Nigeria. Niger Postgrad Med J. 2007, 14 (4): 285-9. Oguonu T, Okafor HU: Comparison of clinical, microscopic and rapid diagnostic test methods in the diagnosis of Plasmodium falciparum malaria in Enugu, Nigeria. Niger Postgrad Med J. 2007, 14 (4): 285-9.
11.
go back to reference Zaccheaus AJ, Ukoh KE, Buseri FI, Awortu TJ: Field Evaluation of SD Biolin Rapid Malaria Diagnostic Test Among asymptomatic Malaria Infected Children in Port Harcourt, Nigeria. Research Journal of Parasitology. 2007, 2: 39-44. 10.3923/jp.2007.39.44.CrossRef Zaccheaus AJ, Ukoh KE, Buseri FI, Awortu TJ: Field Evaluation of SD Biolin Rapid Malaria Diagnostic Test Among asymptomatic Malaria Infected Children in Port Harcourt, Nigeria. Research Journal of Parasitology. 2007, 2: 39-44. 10.3923/jp.2007.39.44.CrossRef
12.
go back to reference Uzochukwu BS, Obikeze EN, Onwujekwe OE, Onoka CA, Griffiths UK: Cost-effectiveness analysis of rapid diagnostic test, microscopy and syndromic approach in the diagnosis of malaria in Nigeria: implications for scaling-up deployment of ACT. Malar J. 2009, 8 (1): 265-10.1186/1475-2875-8-265.CrossRefPubMedPubMedCentral Uzochukwu BS, Obikeze EN, Onwujekwe OE, Onoka CA, Griffiths UK: Cost-effectiveness analysis of rapid diagnostic test, microscopy and syndromic approach in the diagnosis of malaria in Nigeria: implications for scaling-up deployment of ACT. Malar J. 2009, 8 (1): 265-10.1186/1475-2875-8-265.CrossRefPubMedPubMedCentral
13.
go back to reference UNICEF-UNDP-WORLD BANK-WHO: Towards Quality Testing of Malaria Rapid Diagnostic Tests: Evidence and Methods. Report of the UNICEF-UNDP-WORLD BANK-WHO Special Programme for Research and Training in Tropical Diseases, Manila, Philippines. 2006, 4-22. UNICEF-UNDP-WORLD BANK-WHO: Towards Quality Testing of Malaria Rapid Diagnostic Tests: Evidence and Methods. Report of the UNICEF-UNDP-WORLD BANK-WHO Special Programme for Research and Training in Tropical Diseases, Manila, Philippines. 2006, 4-22.
14.
go back to reference Chiodini PL, Bowers K, Jorgensen P, Barnwell JW, Grady KK, Luchavez J, Moody AH, Cenizal A, Bell D: The heat stability of Plasmodium lactate dehydrogenasebased and histidine-rich protein 2-based malaria rapid diagnostic tests. Trans R Soc Trop Med Hyg. 2007, 101: 331-337. 10.1016/j.trstmh.2006.09.007.CrossRefPubMed Chiodini PL, Bowers K, Jorgensen P, Barnwell JW, Grady KK, Luchavez J, Moody AH, Cenizal A, Bell D: The heat stability of Plasmodium lactate dehydrogenasebased and histidine-rich protein 2-based malaria rapid diagnostic tests. Trans R Soc Trop Med Hyg. 2007, 101: 331-337. 10.1016/j.trstmh.2006.09.007.CrossRefPubMed
15.
go back to reference Whitty CJM, Armstrong M, Behrens RH: Self -testing for falciparum malaria with antigencapture cards by travelers with symptoms of malaria. Am J Trop Med Hyg. 2000, 63 (5-6): 295-7.PubMed Whitty CJM, Armstrong M, Behrens RH: Self -testing for falciparum malaria with antigencapture cards by travelers with symptoms of malaria. Am J Trop Med Hyg. 2000, 63 (5-6): 295-7.PubMed
16.
go back to reference Jelinek T, Grobusch MP, Nothdurft HD: Use of dipstick tests for the rapid diagnosis of malaria in nonimmune travelers. J Travel Med. 2000, 7 (4): 175-9. 10.2310/7060.2000.00055.CrossRefPubMed Jelinek T, Grobusch MP, Nothdurft HD: Use of dipstick tests for the rapid diagnosis of malaria in nonimmune travelers. J Travel Med. 2000, 7 (4): 175-9. 10.2310/7060.2000.00055.CrossRefPubMed
18.
go back to reference World Health Organization: 2010, WHO guidelines for the treatment of malaria, WHO World Health Organization: 2010, WHO guidelines for the treatment of malaria, WHO
19.
go back to reference Enugu State Ministry of Health: Health Sector Reform: Implementing the District Health System. 2006, SMOH, Enugu Enugu State Ministry of Health: Health Sector Reform: Implementing the District Health System. 2006, SMOH, Enugu
20.
go back to reference Meremikwu M, Okomo U, Nwachukwu C, Oyo-Ita A, Eke-Njoku J, Okebe J, Oyo-Ita E, Garner P: Anti-malarial drug prescribing practice in private and public facilities in south-east Nigeria: a descriptive study. Malar J. 2007, 6: 55-10.1186/1475-2875-6-55.CrossRefPubMedPubMedCentral Meremikwu M, Okomo U, Nwachukwu C, Oyo-Ita A, Eke-Njoku J, Okebe J, Oyo-Ita E, Garner P: Anti-malarial drug prescribing practice in private and public facilities in south-east Nigeria: a descriptive study. Malar J. 2007, 6: 55-10.1186/1475-2875-6-55.CrossRefPubMedPubMedCentral
21.
go back to reference Chitaka R, Khare AK, Brickling C: Prescribing policy for antimalarials. Afr Health. 1998, 20: 2-5. Chitaka R, Khare AK, Brickling C: Prescribing policy for antimalarials. Afr Health. 1998, 20: 2-5.
22.
go back to reference Msellem ML, Martensson A, Rottlant G, Bhattarai A, et al: Influence of rapid malaria Diagnosis tests on treatment and health outcome in fever patients, Zanzibar- A crossover validation study. Plos Med. 2009, 6 (4): 10.1371/journal.pmed.1000070. Msellem ML, Martensson A, Rottlant G, Bhattarai A, et al: Influence of rapid malaria Diagnosis tests on treatment and health outcome in fever patients, Zanzibar- A crossover validation study. Plos Med. 2009, 6 (4): 10.1371/journal.pmed.1000070.
23.
go back to reference Rennie W, Phetsouvanh R, Lupisan S, Vanisaveth V, Hongvanthong B, Phompida S, Alday P, Fulache M, Lumagui R, Jorgensen P, Bell D, Harvey S: Minimising human error in malaria rapid diagnosis: clarity of written instructions and health worker performance. Trans R Soc Trop Med Hyg. 2007, 101: 9-18. 10.1016/j.trstmh.2006.03.011.CrossRefPubMed Rennie W, Phetsouvanh R, Lupisan S, Vanisaveth V, Hongvanthong B, Phompida S, Alday P, Fulache M, Lumagui R, Jorgensen P, Bell D, Harvey S: Minimising human error in malaria rapid diagnosis: clarity of written instructions and health worker performance. Trans R Soc Trop Med Hyg. 2007, 101: 9-18. 10.1016/j.trstmh.2006.03.011.CrossRefPubMed
24.
go back to reference Luchavez J, Lintag ME, Coll-Black M, Baik F, Bell D: An assessment of various blood collection and transfer methods used for malaria rapid diagnostic tests. Malar J. 2007, 6: 149-10.1186/1475-2875-6-149.CrossRefPubMedPubMedCentral Luchavez J, Lintag ME, Coll-Black M, Baik F, Bell D: An assessment of various blood collection and transfer methods used for malaria rapid diagnostic tests. Malar J. 2007, 6: 149-10.1186/1475-2875-6-149.CrossRefPubMedPubMedCentral
25.
go back to reference Erhun OO, Babalola MO, Erhun WO: Drug regulation and control in Nigeria: The challenge of counterfeit drugs. Journal of Health & Population in Developing Countries. 2001, 4: 23-34. Erhun OO, Babalola MO, Erhun WO: Drug regulation and control in Nigeria: The challenge of counterfeit drugs. Journal of Health & Population in Developing Countries. 2001, 4: 23-34.
26.
go back to reference Onwujekwe O, Kaur H, Dike N, Shu E, Uzochukwu BSC, Hanson K, Okoye V, Okonkwo P: Quality of Anti-malarial drugs provided by public and private health care providers in South-East Nigeria. Malaria Journal. 2009, Accessed June 28 2009, [http://www.pubmedcentral.nih.gov] Onwujekwe O, Kaur H, Dike N, Shu E, Uzochukwu BSC, Hanson K, Okoye V, Okonkwo P: Quality of Anti-malarial drugs provided by public and private health care providers in South-East Nigeria. Malaria Journal. 2009, Accessed June 28 2009, [http://​www.​pubmedcentral.​nih.​gov]
27.
go back to reference Enugu State Ministry of Health: Malaria control activities Report. 2007 Enugu State Ministry of Health: Malaria control activities Report. 2007
28.
go back to reference World Health Organization: WHO Expert Committee on Malaria: twentieth report Geneva, Switzerland. 1998 World Health Organization: WHO Expert Committee on Malaria: twentieth report Geneva, Switzerland. 1998
29.
go back to reference Redd SC, Bloland PB, Kazembe PN, Patrick E, Tembenu R, Campbell CC: Usefulness of clinical case-definitions in guiding therapy for African children with malaria or pneumonia. Lancet. 1992, 340: 1140-1143. 10.1016/0140-6736(92)93160-O.CrossRefPubMed Redd SC, Bloland PB, Kazembe PN, Patrick E, Tembenu R, Campbell CC: Usefulness of clinical case-definitions in guiding therapy for African children with malaria or pneumonia. Lancet. 1992, 340: 1140-1143. 10.1016/0140-6736(92)93160-O.CrossRefPubMed
Metadata
Title
Examining appropriate diagnosis and treatment of malaria: availability and use of rapid diagnostic tests and artemisinin-based combination therapy in public and private health facilities in south east Nigeria
Authors
Benjamin SC Uzochukwu
Lausdeus O Chiegboka
Chibuike Enwereuzo
Usonwanne Nwosu
David Okorafor
Obinna E Onwujekwe
Nkoli P Uguru
Florence T Sibeudu
Ogochukwu P Ezeoke
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2010
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-10-486

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