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Published in: BMC Psychiatry 1/2012

Open Access 01-12-2012 | Research article

In-depth study of personality disorders in first-admission patients with substance use disorders

Authors: Anne-Marit Langås, Ulrik Fredrik Malt, Stein Opjordsmoen

Published in: BMC Psychiatry | Issue 1/2012

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Abstract

Background

Assessment of comorbid personality disorders (PDs) in patients with substance use disorders (SUDs) is challenging due to symptom overlap, additional mental and physical disorders, and limitations of the assessment methods. Our in-depth study applied methods to overcome these difficulties.

Method

A complete catchment area sample of 61 consecutively admitted patients with SUDs, with no previous history of specialized treatment (addiction clinics, psychiatry) were studied, addressing PDs and associated clinical and demographic variables. The thorough assessments included the Psychiatric Research Interview for Substance and Mental Disorders and the Structured Clinical Interview for DSM-IV Axis II Personality Disorders.

Results

Forty-six percent of the SUD patients had at least one PD (16% antisocial [males only]; 13% borderline; and 8% paranoid, avoidant, and obsessive-compulsive, respectively). Cluster C disorders were as prevalent as Cluster B disorders. SUD patients with PDs were younger at the onset of their first SUD and at admission; used more illicit drugs; had more anxiety disorders, particularly social phobia; had more severe depressive symptoms; were more distressed; and less often attended work or school.

Conclusion

The psychiatric comorbidity and symptom load of SUD patients with PDs differed from those of SUD patients without PDs, suggesting different treatment needs, and stressing the value of the assessment of PDs in SUD patients.
Literature
1.
go back to reference Nurnberg HG, Rifkin A, Doddi S: A systematic assessment of the comorbidity of DSM-III-R personality disorders in alcoholic outpatients. Compr Psychiatry. 1993, 34: 447-454. 10.1016/0010-440X(93)90073-D.CrossRefPubMed Nurnberg HG, Rifkin A, Doddi S: A systematic assessment of the comorbidity of DSM-III-R personality disorders in alcoholic outpatients. Compr Psychiatry. 1993, 34: 447-454. 10.1016/0010-440X(93)90073-D.CrossRefPubMed
2.
go back to reference Echeburua E, De Medina RB, Aizpiri J: Alcoholism and personality disorders: an exploratory study. Alcohol Alcohol. 2005, 40: 323-326.CrossRefPubMed Echeburua E, De Medina RB, Aizpiri J: Alcoholism and personality disorders: an exploratory study. Alcohol Alcohol. 2005, 40: 323-326.CrossRefPubMed
3.
go back to reference Echeburua E, De Medina RB, Aizpiri J: Comorbidity of alcohol dependence and personality disorders: a comparative study. Alcohol Alcohol. 2007, 42: 618-622.CrossRefPubMed Echeburua E, De Medina RB, Aizpiri J: Comorbidity of alcohol dependence and personality disorders: a comparative study. Alcohol Alcohol. 2007, 42: 618-622.CrossRefPubMed
4.
go back to reference Zikos E, Gill KJ, Charney DA: Personality disorders among alcoholic outpatients: prevalence and course in treatment. Can J Psychiatry. 2010, 55: 65-73.PubMed Zikos E, Gill KJ, Charney DA: Personality disorders among alcoholic outpatients: prevalence and course in treatment. Can J Psychiatry. 2010, 55: 65-73.PubMed
5.
go back to reference Driessen M, Veltrup C, Wetterling T, John U, Dilling H: Axis I and axis II comorbidity in alcohol dependence and the two types of alcoholism. Alcohol Clin Exp Res. 1998, 22: 77-86. 10.1111/j.1530-0277.1998.tb03619.x.CrossRefPubMed Driessen M, Veltrup C, Wetterling T, John U, Dilling H: Axis I and axis II comorbidity in alcohol dependence and the two types of alcoholism. Alcohol Clin Exp Res. 1998, 22: 77-86. 10.1111/j.1530-0277.1998.tb03619.x.CrossRefPubMed
6.
go back to reference Preuss UW, Johann M, Fehr C, Koller G, Wodarz N, Hesselbrock V, Wong WM, Soyka M: Personality disorders in alcohol-dependent individuals: relationship with alcohol dependence severity. Eur Addict Res. 2009, 15: 188-195. 10.1159/000228929.CrossRefPubMedPubMedCentral Preuss UW, Johann M, Fehr C, Koller G, Wodarz N, Hesselbrock V, Wong WM, Soyka M: Personality disorders in alcohol-dependent individuals: relationship with alcohol dependence severity. Eur Addict Res. 2009, 15: 188-195. 10.1159/000228929.CrossRefPubMedPubMedCentral
7.
go back to reference DeJong CA, van den Brink W, Harteveld FM, van der Wielen EG: Personality disorders in alcoholics and drug addicts. Compr Psychiatry. 1993, 34: 87-94. 10.1016/0010-440X(93)90052-6.CrossRefPubMed DeJong CA, van den Brink W, Harteveld FM, van der Wielen EG: Personality disorders in alcoholics and drug addicts. Compr Psychiatry. 1993, 34: 87-94. 10.1016/0010-440X(93)90052-6.CrossRefPubMed
8.
go back to reference Morgenstern J, Langenbucher J, Labouvie E, Miller KJ: The comorbidity of alcoholism and personality disorders in a clinical population: prevalence rates and relation to alcohol typology variables. J Abnorm Psychol. 1997, 106: 74-84.CrossRefPubMed Morgenstern J, Langenbucher J, Labouvie E, Miller KJ: The comorbidity of alcoholism and personality disorders in a clinical population: prevalence rates and relation to alcohol typology variables. J Abnorm Psychol. 1997, 106: 74-84.CrossRefPubMed
9.
go back to reference Rounsaville BJ, Kranzler HR, Ball S, Tennen H, Poling J, Triffleman E: Personality disorders in substance abusers: relation to substance use. J Nerv Ment Dis. 1998, 186: 87-95. 10.1097/00005053-199802000-00004.CrossRefPubMed Rounsaville BJ, Kranzler HR, Ball S, Tennen H, Poling J, Triffleman E: Personality disorders in substance abusers: relation to substance use. J Nerv Ment Dis. 1998, 186: 87-95. 10.1097/00005053-199802000-00004.CrossRefPubMed
10.
go back to reference Kranzler HR, Satel S, Apter A: Personality disorders and associated features in cocaine-dependent inpatients. Compr Psychiatry. 1994, 35: 335-340. 10.1016/0010-440X(94)90272-0.CrossRefPubMed Kranzler HR, Satel S, Apter A: Personality disorders and associated features in cocaine-dependent inpatients. Compr Psychiatry. 1994, 35: 335-340. 10.1016/0010-440X(94)90272-0.CrossRefPubMed
11.
go back to reference Brooner RK, King VL, Kidorf M, Schmidt CW, Bigelow GE: Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. Arch Gen Psychiatry. 1997, 54: 71-80. 10.1001/archpsyc.1997.01830130077015.CrossRefPubMed Brooner RK, King VL, Kidorf M, Schmidt CW, Bigelow GE: Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. Arch Gen Psychiatry. 1997, 54: 71-80. 10.1001/archpsyc.1997.01830130077015.CrossRefPubMed
12.
go back to reference Van Horn DH, Frank AF: Substance-use situations and abstinence predictions in substance abusers with and without personality disorders. Am J Drug Alcohol Abuse. 1998, 24: 395-404. 10.3109/00952999809016905.CrossRefPubMed Van Horn DH, Frank AF: Substance-use situations and abstinence predictions in substance abusers with and without personality disorders. Am J Drug Alcohol Abuse. 1998, 24: 395-404. 10.3109/00952999809016905.CrossRefPubMed
13.
go back to reference Kokkevi A, Stefanis N, Anastasopoulou E, Kostogianni C: Personality disorders in drug abusers: prevalence and their association with Axis I disorders as predictors of treatment retention. Addict Behav. 1998, 23: 841-853. 10.1016/S0306-4603(98)00071-9.CrossRefPubMed Kokkevi A, Stefanis N, Anastasopoulou E, Kostogianni C: Personality disorders in drug abusers: prevalence and their association with Axis I disorders as predictors of treatment retention. Addict Behav. 1998, 23: 841-853. 10.1016/S0306-4603(98)00071-9.CrossRefPubMed
14.
go back to reference American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders; 4th edn. Text revision. 2000, Washington DC: American Psychiatric Association American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders; 4th edn. Text revision. 2000, Washington DC: American Psychiatric Association
15.
go back to reference WHO: The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. 1993, Geneva: World Health Organization WHO: The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. 1993, Geneva: World Health Organization
16.
go back to reference Verheul R, Kranzler HR, Poling J, Tennen H, Ball S, Rounsaville BJ: Axis I and Axis II disorders in alcoholics and drug addicts: fact or artifact?. J Stud Alcohol. 2000, 61: 101-110.CrossRefPubMed Verheul R, Kranzler HR, Poling J, Tennen H, Ball S, Rounsaville BJ: Axis I and Axis II disorders in alcoholics and drug addicts: fact or artifact?. J Stud Alcohol. 2000, 61: 101-110.CrossRefPubMed
17.
go back to reference Skodol AE, Oldham JM, Gallaher PE: Axis II comorbidity of substance use disorders among patients referred for treatment of personality disorders. Am J Psychiatry. 1999, 156: 733-738.PubMed Skodol AE, Oldham JM, Gallaher PE: Axis II comorbidity of substance use disorders among patients referred for treatment of personality disorders. Am J Psychiatry. 1999, 156: 733-738.PubMed
18.
go back to reference Nace EP, Davis CW, Gaspari JP: Axis II comorbidity in substance abusers. Am J Psychiatry. 1991, 148: 118-120.CrossRefPubMed Nace EP, Davis CW, Gaspari JP: Axis II comorbidity in substance abusers. Am J Psychiatry. 1991, 148: 118-120.CrossRefPubMed
19.
go back to reference Saunders JB, Aasland OG, Babor TF, De La Fuente JR, Grant M: Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption–II. Addiction. 1993, 88: 791-804. 10.1111/j.1360-0443.1993.tb02093.x.CrossRefPubMed Saunders JB, Aasland OG, Babor TF, De La Fuente JR, Grant M: Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption–II. Addiction. 1993, 88: 791-804. 10.1111/j.1360-0443.1993.tb02093.x.CrossRefPubMed
20.
go back to reference Berman AH, Bergman H, Palmstierna T, Schlyter F: Evaluation of the drug use disorders identification test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample. Eur Addict Res. 2005, 11: 22-31. 10.1159/000081413.CrossRefPubMed Berman AH, Bergman H, Palmstierna T, Schlyter F: Evaluation of the drug use disorders identification test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample. Eur Addict Res. 2005, 11: 22-31. 10.1159/000081413.CrossRefPubMed
21.
go back to reference Suppes T, Leverich GS, Keck PE, Nolen WA, Denicoff KD, Altshuler LL, McElroy SL, Rush AJ, Kupka R, Frye MA, Bickel M, Post RM: The stanley foundation bipolar treatment outcome network. II. demographics and illness characteristics of the first 261 patients. J Affect Disord. 2001, 67: 45-59. 10.1016/S0165-0327(01)00432-3.CrossRefPubMed Suppes T, Leverich GS, Keck PE, Nolen WA, Denicoff KD, Altshuler LL, McElroy SL, Rush AJ, Kupka R, Frye MA, Bickel M, Post RM: The stanley foundation bipolar treatment outcome network. II. demographics and illness characteristics of the first 261 patients. J Affect Disord. 2001, 67: 45-59. 10.1016/S0165-0327(01)00432-3.CrossRefPubMed
22.
go back to reference Hasin D, Samet S, Nunes E, Meydan J, Matseoane K, Waxman R: Diagnosis of comorbid psychiatric disorders in substance users assessed with the Psychiatric Research Interview for Substance and Mental Disorders for DSM-IV. Am J Psychiatry. 2006, 163: 689-696. 10.1176/appi.ajp.163.4.689.CrossRefPubMed Hasin D, Samet S, Nunes E, Meydan J, Matseoane K, Waxman R: Diagnosis of comorbid psychiatric disorders in substance users assessed with the Psychiatric Research Interview for Substance and Mental Disorders for DSM-IV. Am J Psychiatry. 2006, 163: 689-696. 10.1176/appi.ajp.163.4.689.CrossRefPubMed
23.
go back to reference Hasin DS, Trautman KD, Miele GM, Samet S, Smith M, Endicott J: Psychiatric research interview for substance and mental disorders (PRISM): reliability for substance abusers. Am J Psychiatry. 1996, 153: 1195-1201.CrossRefPubMed Hasin DS, Trautman KD, Miele GM, Samet S, Smith M, Endicott J: Psychiatric research interview for substance and mental disorders (PRISM): reliability for substance abusers. Am J Psychiatry. 1996, 153: 1195-1201.CrossRefPubMed
24.
go back to reference Maffei C, Fossati A, Agostoni I, Barraco A, Bagnato M, Deborah D, Namia C, Novella L, Petrachi M: Interrater reliability and internal consistency of the structured clinical interview for DSM-IV axis II personality disorders (SCID-II), version 2.0. J Pers Disord. 1997, 11: 279-284. 10.1521/pedi.1997.11.3.279.CrossRefPubMed Maffei C, Fossati A, Agostoni I, Barraco A, Bagnato M, Deborah D, Namia C, Novella L, Petrachi M: Interrater reliability and internal consistency of the structured clinical interview for DSM-IV axis II personality disorders (SCID-II), version 2.0. J Pers Disord. 1997, 11: 279-284. 10.1521/pedi.1997.11.3.279.CrossRefPubMed
26.
go back to reference Vatnaland T, Vatnaland J, Friis S, Opjordsmoen S: Are GAF scores reliable in routine clinical use?. Acta Psychiatr Scand. 2007, 115: 326-330. 10.1111/j.1600-0447.2006.00925.x.CrossRefPubMed Vatnaland T, Vatnaland J, Friis S, Opjordsmoen S: Are GAF scores reliable in routine clinical use?. Acta Psychiatr Scand. 2007, 115: 326-330. 10.1111/j.1600-0447.2006.00925.x.CrossRefPubMed
27.
go back to reference Pedersen G, Hagtvet KA, Karterud S: Generalizability studies of the global assessment of functioning-split version. Compr Psychiatry. 2007, 48: 88-94. 10.1016/j.comppsych.2006.03.008.CrossRefPubMed Pedersen G, Hagtvet KA, Karterud S: Generalizability studies of the global assessment of functioning-split version. Compr Psychiatry. 2007, 48: 88-94. 10.1016/j.comppsych.2006.03.008.CrossRefPubMed
28.
go back to reference Derogatis LR, Rickels K, Rock AF: The SCL-90 and the MMPI: a step in the validation of a new self-report scale. Br J Psychiatry. 1976, 128: 280-289. 10.1192/bjp.128.3.280.CrossRefPubMed Derogatis LR, Rickels K, Rock AF: The SCL-90 and the MMPI: a step in the validation of a new self-report scale. Br J Psychiatry. 1976, 128: 280-289. 10.1192/bjp.128.3.280.CrossRefPubMed
29.
go back to reference Haver B: Screening for psychiatric comorbidity among female alcoholics: the use of a questionnaire (SCL-90) among women early in their treatment programme. Alcohol Alcohol. 1997, 32: 725-730.CrossRefPubMed Haver B: Screening for psychiatric comorbidity among female alcoholics: the use of a questionnaire (SCL-90) among women early in their treatment programme. Alcohol Alcohol. 1997, 32: 725-730.CrossRefPubMed
30.
go back to reference Benjamin AB, Mossman D, Graves NS, Sanders RD: Tests of a symptom checklist to screen for comorbid psychiatric disorders in alcoholism. Compr Psychiatry. 2006, 47: 227-233. 10.1016/j.comppsych.2005.08.003.CrossRefPubMed Benjamin AB, Mossman D, Graves NS, Sanders RD: Tests of a symptom checklist to screen for comorbid psychiatric disorders in alcoholism. Compr Psychiatry. 2006, 47: 227-233. 10.1016/j.comppsych.2005.08.003.CrossRefPubMed
31.
go back to reference Vassend O, Skrondal A: The problem of structural indeterminacy in multidimensional symptom report instruments. The case of SCL-90-R. Behav Res Ther. 1999, 37: 685-701. 10.1016/S0005-7967(98)00182-X.CrossRefPubMed Vassend O, Skrondal A: The problem of structural indeterminacy in multidimensional symptom report instruments. The case of SCL-90-R. Behav Res Ther. 1999, 37: 685-701. 10.1016/S0005-7967(98)00182-X.CrossRefPubMed
32.
go back to reference Trivedi MH, Rush AJ, Ibrahim HM, Carmody TJ, Biggs MM, Suppes T, Crismon ML, Shores-Wilson K, Toprac MG, Dennehy EB, Witte B, Kashner TM: The Inventory of depressive symptomatology, clinician rating (IDS-C) and self-report (IDS-SR), and the quick inventory of depressive symptomatology, clinician rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders: a psychometric evaluation. Psychol Med. 2004, 34: 73-82. 10.1017/S0033291703001107.CrossRefPubMed Trivedi MH, Rush AJ, Ibrahim HM, Carmody TJ, Biggs MM, Suppes T, Crismon ML, Shores-Wilson K, Toprac MG, Dennehy EB, Witte B, Kashner TM: The Inventory of depressive symptomatology, clinician rating (IDS-C) and self-report (IDS-SR), and the quick inventory of depressive symptomatology, clinician rating (QIDS-C) and Self-Report (QIDS-SR) in public sector patients with mood disorders: a psychometric evaluation. Psychol Med. 2004, 34: 73-82. 10.1017/S0033291703001107.CrossRefPubMed
33.
go back to reference Langas AM, Malt UF, Opjordsmoen S: Comorbid mental disorders in substance users from a single catchment area - a clinical study. BMC Psychiatry. 2011, 11: 25-10.1186/1471-244X-11-25.CrossRefPubMedPubMedCentral Langas AM, Malt UF, Opjordsmoen S: Comorbid mental disorders in substance users from a single catchment area - a clinical study. BMC Psychiatry. 2011, 11: 25-10.1186/1471-244X-11-25.CrossRefPubMedPubMedCentral
34.
go back to reference Landheim AS, Bakken K, Vaglum P: Gender differences in the prevalence of symptom disorders and personality disorders among poly-substance abusers and pure alcoholics. Substance abusers treated in two counties in Norway. Eur Addict Res. 2003, 9: 8-17. 10.1159/000067732.CrossRefPubMed Landheim AS, Bakken K, Vaglum P: Gender differences in the prevalence of symptom disorders and personality disorders among poly-substance abusers and pure alcoholics. Substance abusers treated in two counties in Norway. Eur Addict Res. 2003, 9: 8-17. 10.1159/000067732.CrossRefPubMed
35.
go back to reference Ravndal E, Vaglum P: The millon clinical multiaxial inventory II: stability over time? A seven-year follow-up study of substance abusers in treatment. Eur Addict Res. 2010, 16: 146-151. 10.1159/000313337.CrossRefPubMed Ravndal E, Vaglum P: The millon clinical multiaxial inventory II: stability over time? A seven-year follow-up study of substance abusers in treatment. Eur Addict Res. 2010, 16: 146-151. 10.1159/000313337.CrossRefPubMed
36.
go back to reference Torgersen S, Kringlen E, Cramer V: The prevalence of personality disorders in a community sample. Arch Gen Psychiatry. 2001, 58: 590-596. 10.1001/archpsyc.58.6.590.CrossRefPubMed Torgersen S, Kringlen E, Cramer V: The prevalence of personality disorders in a community sample. Arch Gen Psychiatry. 2001, 58: 590-596. 10.1001/archpsyc.58.6.590.CrossRefPubMed
37.
go back to reference Huang Y, Kotov R, de Girolamo G, Preti A, Angermeyer M, Benjet C, Demyttenaere K, de Graaf R, Gureje O, Karam AN, Lee S, Lepine JP, Matschinger H, Posada-Villa J, Suliman S, Vilagut G, Kessler RC: DSM-IV personality disorders in the WHO world mental health surveys. Br J Psychiatry. 2009, 195: 46-53. 10.1192/bjp.bp.108.058552.CrossRefPubMedPubMedCentral Huang Y, Kotov R, de Girolamo G, Preti A, Angermeyer M, Benjet C, Demyttenaere K, de Graaf R, Gureje O, Karam AN, Lee S, Lepine JP, Matschinger H, Posada-Villa J, Suliman S, Vilagut G, Kessler RC: DSM-IV personality disorders in the WHO world mental health surveys. Br J Psychiatry. 2009, 195: 46-53. 10.1192/bjp.bp.108.058552.CrossRefPubMedPubMedCentral
38.
go back to reference Trull TJ, Jahng S, Tomko RL, Wood PK, Sher KJ: Revised NESARC personality disorder diagnoses: gender, prevalence, and comorbidity with substance dependence disorders. J Pers Disord. 2010, 24: 412-426. 10.1521/pedi.2010.24.4.412.CrossRefPubMedPubMedCentral Trull TJ, Jahng S, Tomko RL, Wood PK, Sher KJ: Revised NESARC personality disorder diagnoses: gender, prevalence, and comorbidity with substance dependence disorders. J Pers Disord. 2010, 24: 412-426. 10.1521/pedi.2010.24.4.412.CrossRefPubMedPubMedCentral
39.
go back to reference Berkson J: Limitations of the application of fourfold table analysis to hospital data. Biometrics Bulletin. 1946, 2: 47-53. 10.2307/3002000.CrossRefPubMed Berkson J: Limitations of the application of fourfold table analysis to hospital data. Biometrics Bulletin. 1946, 2: 47-53. 10.2307/3002000.CrossRefPubMed
40.
go back to reference Grant BF, Hasin DS, Stinson FS, Dawson DA, Patricia CS, June RW, Huang B: Co-occurrence of 12-month mood and anxiety disorders and personality disorders in the US: results from the national epidemiologic survey on alcohol and related conditions. J Psychiatr Res. 2005, 39: 1-9. 10.1016/j.jpsychires.2004.05.004.CrossRefPubMed Grant BF, Hasin DS, Stinson FS, Dawson DA, Patricia CS, June RW, Huang B: Co-occurrence of 12-month mood and anxiety disorders and personality disorders in the US: results from the national epidemiologic survey on alcohol and related conditions. J Psychiatr Res. 2005, 39: 1-9. 10.1016/j.jpsychires.2004.05.004.CrossRefPubMed
41.
go back to reference Malt U, Myhrer T, Blikra G, Hoivik B: Psychopathology and accidental injuries. [Erratum appears in Acta Psychiatr Scand 1988, 77:240]. Acta Psychiatr Scand. 1987, 76: 261-271. 10.1111/j.1600-0447.1987.tb02894.x.CrossRefPubMed Malt U, Myhrer T, Blikra G, Hoivik B: Psychopathology and accidental injuries. [Erratum appears in Acta Psychiatr Scand 1988, 77:240]. Acta Psychiatr Scand. 1987, 76: 261-271. 10.1111/j.1600-0447.1987.tb02894.x.CrossRefPubMed
42.
go back to reference Langas AM, Malt UF, Opjordsmoen S: Substance use disorders and comorbid mental disorders in first-time admitted patients from a catchment area. Eur Addict Res. 2012, 18: 16-25. 10.1159/000332234.CrossRefPubMed Langas AM, Malt UF, Opjordsmoen S: Substance use disorders and comorbid mental disorders in first-time admitted patients from a catchment area. Eur Addict Res. 2012, 18: 16-25. 10.1159/000332234.CrossRefPubMed
43.
go back to reference Merikangas KR, Angst J: Comorbidity and social phobia: evidence from clinical, epidemiologic, and genetic studies. Eur Arch Psychiatry Clin Neurosci. 1995, 244: 297-303. 10.1007/BF02190407.CrossRefPubMed Merikangas KR, Angst J: Comorbidity and social phobia: evidence from clinical, epidemiologic, and genetic studies. Eur Arch Psychiatry Clin Neurosci. 1995, 244: 297-303. 10.1007/BF02190407.CrossRefPubMed
44.
go back to reference Grekin ER, Sher KJ, Wood PK: Personality and substance dependence symptoms: modeling substance-specific traits. Psychol Addict Behav. 2006, 20: 415-424.CrossRefPubMed Grekin ER, Sher KJ, Wood PK: Personality and substance dependence symptoms: modeling substance-specific traits. Psychol Addict Behav. 2006, 20: 415-424.CrossRefPubMed
45.
go back to reference Kessler RC, Amminger GP, Aguilar-Gaxiola S, Alonso J, Lee S, Ustun TB: Age of onset of mental disorders: a review of recent literature. Curr Opin Psychiatry. 2007, 20: 359-364. 10.1097/YCO.0b013e32816ebc8c.CrossRefPubMedPubMedCentral Kessler RC, Amminger GP, Aguilar-Gaxiola S, Alonso J, Lee S, Ustun TB: Age of onset of mental disorders: a review of recent literature. Curr Opin Psychiatry. 2007, 20: 359-364. 10.1097/YCO.0b013e32816ebc8c.CrossRefPubMedPubMedCentral
46.
go back to reference Douglas KR, Chan G, Gelernter J, Arias AJ, Anton RF, Weiss RD, Brady K, Poling J, Farrer L, Kranzler HR: Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders. Addict Behav. 2010, 35: 7-13. 10.1016/j.addbeh.2009.07.004.CrossRefPubMed Douglas KR, Chan G, Gelernter J, Arias AJ, Anton RF, Weiss RD, Brady K, Poling J, Farrer L, Kranzler HR: Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders. Addict Behav. 2010, 35: 7-13. 10.1016/j.addbeh.2009.07.004.CrossRefPubMed
47.
go back to reference Volkow ND, Li TK: Drug addiction: the neurobiology of behaviour gone awry. Nat Rev Neurosci. 2004, 5: 963-970. 10.1038/nrn1539.CrossRefPubMed Volkow ND, Li TK: Drug addiction: the neurobiology of behaviour gone awry. Nat Rev Neurosci. 2004, 5: 963-970. 10.1038/nrn1539.CrossRefPubMed
48.
go back to reference Conrod PJ, Castellanos N, Mackie C: Personality-targeted interventions delay the growth of adolescent drinking and binge drinking. J Child Psychol Psychiatry. 2008, 49: 181-190.PubMed Conrod PJ, Castellanos N, Mackie C: Personality-targeted interventions delay the growth of adolescent drinking and binge drinking. J Child Psychol Psychiatry. 2008, 49: 181-190.PubMed
49.
go back to reference Krampe H, Wagner T, Stawicki S, Bartels C, Aust C, Kroener-Herwig B, Kuefner H, Ehrenreich H: Personality disorder and chronicity of addiction as independent outcome predictors in alcoholism treatment. Psychiatr Serv. 2006, 57: 708-712. 10.1176/appi.ps.57.5.708.CrossRefPubMed Krampe H, Wagner T, Stawicki S, Bartels C, Aust C, Kroener-Herwig B, Kuefner H, Ehrenreich H: Personality disorder and chronicity of addiction as independent outcome predictors in alcoholism treatment. Psychiatr Serv. 2006, 57: 708-712. 10.1176/appi.ps.57.5.708.CrossRefPubMed
50.
go back to reference Haro G, Mateu C, Martinez-Raga J, Valderrama JC, Castellano M, Cervera G: The role of personality disorders on drug dependence treatment outcomes following inpatient detoxification. Eur Psychiatry. 2004, 19: 187-192. 10.1016/j.eurpsy.2004.04.004.CrossRefPubMed Haro G, Mateu C, Martinez-Raga J, Valderrama JC, Castellano M, Cervera G: The role of personality disorders on drug dependence treatment outcomes following inpatient detoxification. Eur Psychiatry. 2004, 19: 187-192. 10.1016/j.eurpsy.2004.04.004.CrossRefPubMed
51.
go back to reference Verheul R, van den Brink W, Hartgers C: Personality disorders predict relapse in alcoholic patients. Addict Behav. 1998, 23: 869-882. 10.1016/S0306-4603(98)00065-3.CrossRefPubMed Verheul R, van den Brink W, Hartgers C: Personality disorders predict relapse in alcoholic patients. Addict Behav. 1998, 23: 869-882. 10.1016/S0306-4603(98)00065-3.CrossRefPubMed
52.
go back to reference Grayson CE, Nolen-Hoeksema S: Motives to drink as mediators between childhood sexual assault and alcohol problems in adult women. J Trauma Stress. 2005, 18: 137-145. 10.1002/jts.20021.CrossRefPubMed Grayson CE, Nolen-Hoeksema S: Motives to drink as mediators between childhood sexual assault and alcohol problems in adult women. J Trauma Stress. 2005, 18: 137-145. 10.1002/jts.20021.CrossRefPubMed
53.
go back to reference Crawford TN, Cohen P, First MB, Skodol AE, Johnson JG, Kasen S: Comorbid Axis I and Axis II disorders in early adolescence: outcomes 20 years later. Arch Gen Psychiatry. 2008, 65: 641-648. 10.1001/archpsyc.65.6.641.CrossRefPubMed Crawford TN, Cohen P, First MB, Skodol AE, Johnson JG, Kasen S: Comorbid Axis I and Axis II disorders in early adolescence: outcomes 20 years later. Arch Gen Psychiatry. 2008, 65: 641-648. 10.1001/archpsyc.65.6.641.CrossRefPubMed
54.
go back to reference Pettinati HM, Pierce JD, Belden PP, Meyers K: The relationship of Axis II personality disorders to other known predictors of addiction treatment outcome. Am J Addict. 1999, 8: 136-147. 10.1080/105504999305947.CrossRefPubMed Pettinati HM, Pierce JD, Belden PP, Meyers K: The relationship of Axis II personality disorders to other known predictors of addiction treatment outcome. Am J Addict. 1999, 8: 136-147. 10.1080/105504999305947.CrossRefPubMed
55.
go back to reference Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR: Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission. Am J Psychiatry. 2004, 161: 2108-2114. 10.1176/appi.ajp.161.11.2108.CrossRefPubMed Zanarini MC, Frankenburg FR, Hennen J, Reich DB, Silk KR: Axis I comorbidity in patients with borderline personality disorder: 6-year follow-up and prediction of time to remission. Am J Psychiatry. 2004, 161: 2108-2114. 10.1176/appi.ajp.161.11.2108.CrossRefPubMed
Metadata
Title
In-depth study of personality disorders in first-admission patients with substance use disorders
Authors
Anne-Marit Langås
Ulrik Fredrik Malt
Stein Opjordsmoen
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2012
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-12-180

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