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BMC Psychiatry
Published in: BMC Psychiatry 1/2012

Open Access 01-12-2012 | Study protocol

Internet-based self-help treatment for depression in multiple sclerosis: study protocol of a randomized controlled trial

Authors: Rosa E Boeschoten, Joost Dekker, Bernard MJ Uitdehaag, Chris H Polman, Emma H Collette, Pim Cuijpers, Aartjan TF Beekman, Patricia van Oppen

Published in: BMC Psychiatry | Issue 1/2012

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Abstract

Background

Depression in MS patients is frequent but often not treated adequately. An important underlying factor may be physical limitations that preclude face-to-face contact. Internet-based treatment showed to be effective for depressive symptoms in general and could thus be a promising tool for treatment in MS.

Methods/design

Here, we present a study protocol to investigate the effectiveness of a 5 week Internet-based self-help problem solving treatment (PST) for depressive symptoms in MS patients in a randomized controlled trial. We aim to include 166 MS patients with moderate to severe depressive symptoms who will be randomly assigned to an Internet-based intervention (with or without supportive text-messages) or waiting list control group. The primary outcome is the change in depressive symptoms defined by a change in the sum score on the Beck Depression Inventory (BDI-II). Secondary outcomes will include measures of anxiety, fatigue, cognitive functioning, physical and psychological impact of MS, quality of life, problem solving skills, social support, mastery, satisfaction and compliance rate. Assessments will take place at baseline (T0), within a week after the intervention (T1), at four months (T2) and at ten months follow-up (T3: only the intervention group). The control group will be measured at the same moments in time. Analysis will be based on the intention-to-treat principle.

Discussion

If shown to be effective, Internet-based PST will offer new possibilities to reach and treat MS patients with depressive symptoms and to improve the quality of care.

Trial Registration

The Dutch Cochrane Center, NTR2772
Appendix
Available only for authorised users
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Metadata
Title
Internet-based self-help treatment for depression in multiple sclerosis: study protocol of a randomized controlled trial
Authors
Rosa E Boeschoten
Joost Dekker
Bernard MJ Uitdehaag
Chris H Polman
Emma H Collette
Pim Cuijpers
Aartjan TF Beekman
Patricia van Oppen
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2012
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-12-137

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