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BMC Psychiatry
Published in: BMC Psychiatry 1/2011

Open Access 01-12-2011 | Research article

Reduced antioxidant defense in early onset first-episode psychosis: a case-control study

Authors: Juan Antonio Micó, Maria Olga Rojas-Corrales, Juan Gibert-Rahola, Mara Parellada, Dolores Moreno, David Fraguas, Montserrat Graell, Javier Gil, Jon Irazusta, Josefina Castro-Fornieles, Cesar Soutullo, Celso Arango, Soraya Otero, Ana Navarro, Inmaculada Baeza, Mónica Martínez-Cengotitabengoa, Ana González-Pinto

Published in: BMC Psychiatry | Issue 1/2011

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Abstract

Background

Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group.

Methods

Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls.

Results

A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients.

Conclusions

Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.
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Metadata
Title
Reduced antioxidant defense in early onset first-episode psychosis: a case-control study
Authors
Juan Antonio Micó
Maria Olga Rojas-Corrales
Juan Gibert-Rahola
Mara Parellada
Dolores Moreno
David Fraguas
Montserrat Graell
Javier Gil
Jon Irazusta
Josefina Castro-Fornieles
Cesar Soutullo
Celso Arango
Soraya Otero
Ana Navarro
Inmaculada Baeza
Mónica Martínez-Cengotitabengoa
Ana González-Pinto
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2011
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-11-26

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