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Published in: BMC Psychiatry 1/2010

Open Access 01-12-2010 | Study protocol

The ANU WellBeing study: a protocol for a quasi-factorial randomised controlled trial of the effectiveness of an Internet support group and an automated Internet intervention for depression

Authors: Kathleen M Griffiths, Dimity Crisp, Helen Christensen, Andrew J Mackinnon, Kylie Bennett

Published in: BMC Psychiatry | Issue 1/2010

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Abstract

Background

Recent projections suggest that by the year 2030 depression will be the primary cause of disease burden among developed countries. Delivery of accessible consumer-focused evidenced-based services may be an important element in reducing this burden. Many consumers report a preference for self-help modes of delivery. The Internet offers a promising modality for delivering such services and there is now evidence that automated professionally developed self-help psychological interventions can be effective. By contrast, despite their popularity, there is little evidence as to the effectiveness of Internet support groups which provide peer-to-peer mutual support.

Methods/Design

Members of the community with elevated psychological distress were randomised to receive one of the following: (1) Internet Support Group (ISG) intervention, (2) a multi-module automated psychoeducational and skills Internet Training Program (ITP), (3) a combination of the ISG and ITP, or (4) an Internet Attention Control website (IAC) comprising health and wellbeing information and question and answer modules. Each intervention was 12 weeks long. Assessments were conducted at baseline, post-intervention, 6 and 12 months to examine depressive symptoms, social support, self-esteem, quality of life, depression literacy, stigma and help-seeking for depression. Participants were recruited through a screening postal survey sent to 70,000 Australians aged 18 to 65 years randomly selected from four rural and four metropolitan regions in Australia.

Discussion

To our knowledge this study is the first randomised controlled trial of the effectiveness of a depression ISG.

Trial registration

Current Controlled Trials ISRCTN65657330.
Appendix
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Literature
1.
go back to reference World Health Organization: The global burden of disease: 2004 update. 2008, Geneva: World Health Organization World Health Organization: The global burden of disease: 2004 update. 2008, Geneva: World Health Organization
2.
go back to reference Malhi G, Adams D, Porter R, Wignall A, Lape L, O'Connor N, Paton M, Newton L, Walter G, Taylor A, et al: Clinical overview: Clinical practice recommendations for depression. Acta Psychiatrica Scandinavica. 2009, 119 (Suppl 439): 8-26. 10.1111/j.1600-0447.2009.01382.x.CrossRef Malhi G, Adams D, Porter R, Wignall A, Lape L, O'Connor N, Paton M, Newton L, Walter G, Taylor A, et al: Clinical overview: Clinical practice recommendations for depression. Acta Psychiatrica Scandinavica. 2009, 119 (Suppl 439): 8-26. 10.1111/j.1600-0447.2009.01382.x.CrossRef
3.
go back to reference National Institute for Clinical Excellence (NICE): Depression: Management of depression primary and secondary care. 2004, National Collaborating Centre for Mental Health, National Institute for Clinical Excellence National Institute for Clinical Excellence (NICE): Depression: Management of depression primary and secondary care. 2004, National Collaborating Centre for Mental Health, National Institute for Clinical Excellence
4.
go back to reference Andrews G, Sanderson K, Slade T, Issakidis C: Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment. Bulletin of the World Health Organization. 2000, 78: 446-454.PubMedPubMedCentral Andrews G, Sanderson K, Slade T, Issakidis C: Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment. Bulletin of the World Health Organization. 2000, 78: 446-454.PubMedPubMedCentral
5.
go back to reference Australian Institute of Health and Welfare: Rural, regional and remote health: Indicators of health. Rural Health Series. 2005, Canberra: Australian Institute of Health and Welfare Australian Institute of Health and Welfare: Rural, regional and remote health: Indicators of health. Rural Health Series. 2005, Canberra: Australian Institute of Health and Welfare
6.
go back to reference Barney LJ, Griffiths KM, Jorm AF, Christensen H: Stigma about depression and its impact on help-seeking intentions. Australian and New Zealand Journal of Psychiatry. 2006, 40: 51-54.CrossRefPubMed Barney LJ, Griffiths KM, Jorm AF, Christensen H: Stigma about depression and its impact on help-seeking intentions. Australian and New Zealand Journal of Psychiatry. 2006, 40: 51-54.CrossRefPubMed
7.
go back to reference Griffiths K, Farrer L, Christensen H: The efficacy of Internet interventions for depression and anxiety disorders: A review of randomised controlled trials. Med J Aust. Griffiths K, Farrer L, Christensen H: The efficacy of Internet interventions for depression and anxiety disorders: A review of randomised controlled trials. Med J Aust.
8.
go back to reference Christensen H, Griffiths K, Jorm A: Delivering interventions for depression by using the internet: Randomised controlled trial. British Medical Journal. 2004, 328: 265-270. 10.1136/bmj.37945.566632.EE.CrossRefPubMedPubMedCentral Christensen H, Griffiths K, Jorm A: Delivering interventions for depression by using the internet: Randomised controlled trial. British Medical Journal. 2004, 328: 265-270. 10.1136/bmj.37945.566632.EE.CrossRefPubMedPubMedCentral
9.
go back to reference Mackinnon A, Griffiths KM, Christensen H: Comparative randomised trial of online cognitive-behavioural therapy and an information website for depression: 12-month outcomes. British Journal of Psychiatry. 2008, 192: 130-134. 10.1192/bjp.bp.106.032078.CrossRefPubMed Mackinnon A, Griffiths KM, Christensen H: Comparative randomised trial of online cognitive-behavioural therapy and an information website for depression: 12-month outcomes. British Journal of Psychiatry. 2008, 192: 130-134. 10.1192/bjp.bp.106.032078.CrossRefPubMed
10.
go back to reference Christensen H, Griffiths K, Mackinnon A, Brittliffe K: Online randomized controlled trial of brief and full cognitive behaviour therapy for depression. Psychological Medicine. 2006, 36: 1737-1746. 10.1017/S0033291706008695.CrossRefPubMed Christensen H, Griffiths K, Mackinnon A, Brittliffe K: Online randomized controlled trial of brief and full cognitive behaviour therapy for depression. Psychological Medicine. 2006, 36: 1737-1746. 10.1017/S0033291706008695.CrossRefPubMed
11.
go back to reference Spek V, Cuijpers P, Nyklicek I, Smits N, Riper H, Keyzer J, Pop V: One-year follow-up results of a randomized controlled clinical trial on internet-based cognitive behavioural therapy for subthreshold depression in people over 50 years. Psychological Medicine. 2008, 38: 635-639. 10.1017/S0033291707002590.CrossRefPubMed Spek V, Cuijpers P, Nyklicek I, Smits N, Riper H, Keyzer J, Pop V: One-year follow-up results of a randomized controlled clinical trial on internet-based cognitive behavioural therapy for subthreshold depression in people over 50 years. Psychological Medicine. 2008, 38: 635-639. 10.1017/S0033291707002590.CrossRefPubMed
12.
go back to reference Spek V, Nyklicek I, Smits N, Cuijpers PIM, Riper H, Keyzer J, Pop V: Internet-based cognitive behavioural therapy for subthreshold depression in people over 50 years old: a randomized controlled clinical trial. Psychological Medicine. 2007, 37: 1797-1806.PubMed Spek V, Nyklicek I, Smits N, Cuijpers PIM, Riper H, Keyzer J, Pop V: Internet-based cognitive behavioural therapy for subthreshold depression in people over 50 years old: a randomized controlled clinical trial. Psychological Medicine. 2007, 37: 1797-1806.PubMed
13.
go back to reference Clarke G, Eubanks D, Reid E, Kelleher C, O'Connor E, DeBar L, Lynch F, Nunley S, Gullion C: Overcoming Depression on the Internet (ODIN) (2): A randomised trial of a self-help depression skills program with reminders. Journal of Medical Internet Research. 2005, 7: e16-10.2196/jmir.7.2.e16.CrossRefPubMedPubMedCentral Clarke G, Eubanks D, Reid E, Kelleher C, O'Connor E, DeBar L, Lynch F, Nunley S, Gullion C: Overcoming Depression on the Internet (ODIN) (2): A randomised trial of a self-help depression skills program with reminders. Journal of Medical Internet Research. 2005, 7: e16-10.2196/jmir.7.2.e16.CrossRefPubMedPubMedCentral
14.
go back to reference Meyer B, Berger T, Caspar F, Beevers C, Andersson G, Weiss M: Effectiveness of a novel integrative online treatment for depression (Deprexis): Randomized controlled trial. Journal of Medical Internet Research. 2009, 11: e15-10.2196/jmir.1151.CrossRefPubMedPubMedCentral Meyer B, Berger T, Caspar F, Beevers C, Andersson G, Weiss M: Effectiveness of a novel integrative online treatment for depression (Deprexis): Randomized controlled trial. Journal of Medical Internet Research. 2009, 11: e15-10.2196/jmir.1151.CrossRefPubMedPubMedCentral
15.
go back to reference Griffiths KM, Christensen H, Jorm AF, Evans K, Groves C: Effect of web-based depression literacy and cognitive-behavioural therapy interventions on stigmatizing attitudes to depression: Randomised controlled trail. British Journal of Psychiatry. 2004, 185: Griffiths KM, Christensen H, Jorm AF, Evans K, Groves C: Effect of web-based depression literacy and cognitive-behavioural therapy interventions on stigmatizing attitudes to depression: Randomised controlled trail. British Journal of Psychiatry. 2004, 185:
16.
go back to reference Finkelstein J, Lapshin O: Reducing depression stigma using a web-based program. International Journal of Medical Informatics. 2007, 76: 726-734. 10.1016/j.ijmedinf.2006.07.004.CrossRefPubMed Finkelstein J, Lapshin O: Reducing depression stigma using a web-based program. International Journal of Medical Informatics. 2007, 76: 726-734. 10.1016/j.ijmedinf.2006.07.004.CrossRefPubMed
17.
go back to reference Griffiths KM, Christensen H: Internet-based mental health care programs: A powerful tool in the rural medical kit. Australian Journal of Rural Health. 2007, 15: 81-87. 10.1111/j.1440-1584.2007.00859.x.CrossRefPubMed Griffiths KM, Christensen H: Internet-based mental health care programs: A powerful tool in the rural medical kit. Australian Journal of Rural Health. 2007, 15: 81-87. 10.1111/j.1440-1584.2007.00859.x.CrossRefPubMed
18.
go back to reference Eysenbach G, Powell J, Englesakis M, Rizo C, Stern A: Health related virtual communities and electronic support groups: A systematic review of the effects of online peer to peer interactions. British Medical Journal. 2004, 328: 1166-10.1136/bmj.328.7449.1166.CrossRefPubMedPubMedCentral Eysenbach G, Powell J, Englesakis M, Rizo C, Stern A: Health related virtual communities and electronic support groups: A systematic review of the effects of online peer to peer interactions. British Medical Journal. 2004, 328: 1166-10.1136/bmj.328.7449.1166.CrossRefPubMedPubMedCentral
19.
go back to reference Davison K: Who talks? The social psychology of illness support groups. American Psychologist. 2000, 55: 205-217. 10.1037/0003-066X.55.2.205.CrossRefPubMed Davison K: Who talks? The social psychology of illness support groups. American Psychologist. 2000, 55: 205-217. 10.1037/0003-066X.55.2.205.CrossRefPubMed
20.
go back to reference Griffiths KM, Calear AL, Banfield M, Tam A: Systematic review on Internet Support Groups (ISGs) and depression (2): What is known about depression ISGs?. Journal of Medical Internet Research. 2009, 11: Griffiths KM, Calear AL, Banfield M, Tam A: Systematic review on Internet Support Groups (ISGs) and depression (2): What is known about depression ISGs?. Journal of Medical Internet Research. 2009, 11:
21.
go back to reference Houston TK, Cooper LA, Ford DE: Internet support groups for depression: A 1-year prospective cohort study. American Journal of Psychiatry. 2002, 159: 2062-2068. 10.1176/appi.ajp.159.12.2062.CrossRefPubMed Houston TK, Cooper LA, Ford DE: Internet support groups for depression: A 1-year prospective cohort study. American Journal of Psychiatry. 2002, 159: 2062-2068. 10.1176/appi.ajp.159.12.2062.CrossRefPubMed
22.
go back to reference Winzelberg AJ, Classen C, Alperts GW, Roberts H, Koopman C, Adams RE, Ernst H, Dev P, Barr Taylor C: Evaluation of an Internet support group for women with primary breast cancer. Cancer. 2003, 97: 1164-1173. 10.1002/cncr.11174.CrossRefPubMed Winzelberg AJ, Classen C, Alperts GW, Roberts H, Koopman C, Adams RE, Ernst H, Dev P, Barr Taylor C: Evaluation of an Internet support group for women with primary breast cancer. Cancer. 2003, 97: 1164-1173. 10.1002/cncr.11174.CrossRefPubMed
23.
go back to reference Barak A, Boniel-Nissim M, Suler J: Fostering empowerment in online support groups. Computers in Human Behaviour. 2008, 24: 1867-1883. 10.1016/j.chb.2008.02.004.CrossRef Barak A, Boniel-Nissim M, Suler J: Fostering empowerment in online support groups. Computers in Human Behaviour. 2008, 24: 1867-1883. 10.1016/j.chb.2008.02.004.CrossRef
24.
go back to reference van Uden-Kraan CF, Drossaert CHC, Taal E, Shaw BR, Seydel ER, Laar van de MAFJ: Empowering processes and outcomes of participation in Online Support Groups for patients with breast cancer, arthritis, or fibromyalgia. Qualitative Health Research. 2008, 18: 10.1177/1049732307313429. van Uden-Kraan CF, Drossaert CHC, Taal E, Shaw BR, Seydel ER, Laar van de MAFJ: Empowering processes and outcomes of participation in Online Support Groups for patients with breast cancer, arthritis, or fibromyalgia. Qualitative Health Research. 2008, 18: 10.1177/1049732307313429.
26.
go back to reference Christensen H, Griffiths KM, Farrer L: Adherence in Internet interventions for anxiety and depression: Systematic review. Journal of Medical Internet Research. 2009, 11: 10.2196/jmir.1194. Christensen H, Griffiths KM, Farrer L: Adherence in Internet interventions for anxiety and depression: Systematic review. Journal of Medical Internet Research. 2009, 11: 10.2196/jmir.1194.
27.
go back to reference Griffiths KM, Farrer L, Christensen H: The efficacy of Internet interventions for depression and anxiety disorders: A review of randomised controlled trials. Medical Journal of Australia. Griffiths KM, Farrer L, Christensen H: The efficacy of Internet interventions for depression and anxiety disorders: A review of randomised controlled trials. Medical Journal of Australia.
28.
go back to reference Patten SB: Prevention of depressive symptoms through the use of distance technologies. Psychiatric Services. 2003, 54: 396-398. 10.1176/appi.ps.54.3.396.CrossRefPubMed Patten SB: Prevention of depressive symptoms through the use of distance technologies. Psychiatric Services. 2003, 54: 396-398. 10.1176/appi.ps.54.3.396.CrossRefPubMed
29.
go back to reference Klein B, Richards J, Austin D: Efficacy of Internet therapy for panic disorder. Journal of Behavior Therapy & Experimental Psychiatry. 2006, 37: 213-238. 10.1016/j.jbtep.2005.07.001.CrossRef Klein B, Richards J, Austin D: Efficacy of Internet therapy for panic disorder. Journal of Behavior Therapy & Experimental Psychiatry. 2006, 37: 213-238. 10.1016/j.jbtep.2005.07.001.CrossRef
30.
go back to reference Richards J, Klein B, Austin D: Internet cognitive behavioural therapy for panic disorder: Does the inclusion of stress management information improve end-state functioning?. Clinical Psychologist. 2006, 10: 2-15. 10.1080/13284200500378795.CrossRef Richards J, Klein B, Austin D: Internet cognitive behavioural therapy for panic disorder: Does the inclusion of stress management information improve end-state functioning?. Clinical Psychologist. 2006, 10: 2-15. 10.1080/13284200500378795.CrossRef
31.
go back to reference Donker T, Griffiths KM, Cuijpers P, Christensen H: Psychoeducation for depression, anxiety and psychological distress: A meta-analysis. BMC Medicine. 2009, 7: 79-10.1186/1741-7015-7-79.CrossRefPubMedPubMedCentral Donker T, Griffiths KM, Cuijpers P, Christensen H: Psychoeducation for depression, anxiety and psychological distress: A meta-analysis. BMC Medicine. 2009, 7: 79-10.1186/1741-7015-7-79.CrossRefPubMedPubMedCentral
32.
go back to reference Australian Bureau of Statistics: Patterns of Internet access in Australia. 2006, Canberra, A.C.T.: Author Australian Bureau of Statistics: Patterns of Internet access in Australia. 2006, Canberra, A.C.T.: Author
33.
go back to reference Christensen H, Griffiths KM, Jorm AF: Delivering interventions for depression by using the internet: Randomised controlled trial. British Medical Journal. 2004, 328: Christensen H, Griffiths KM, Jorm AF: Delivering interventions for depression by using the internet: Randomised controlled trial. British Medical Journal. 2004, 328:
34.
go back to reference ICH E9 Expert Working Group: Statistical principles for clinical trials: ICH harmonized tripartite guideline. Statistics in Medicine. 1999, 18: 1905-1942. ICH E9 Expert Working Group: Statistical principles for clinical trials: ICH harmonized tripartite guideline. Statistics in Medicine. 1999, 18: 1905-1942.
35.
go back to reference Radloff LS: The CES-D scale: A self report depression scale for research in the general population. Applied Psychological Measurement. 1977, 1: 385-401. 10.1177/014662167700100306.CrossRef Radloff LS: The CES-D scale: A self report depression scale for research in the general population. Applied Psychological Measurement. 1977, 1: 385-401. 10.1177/014662167700100306.CrossRef
36.
go back to reference Meyers T, Miller M, Metzger R, Borkovec T: Development and validation of the Penn State Worry Questionnaire. Behaviour Research and Therapy. 1990, 28: 487-495. 10.1016/0005-7967(90)90135-6.CrossRef Meyers T, Miller M, Metzger R, Borkovec T: Development and validation of the Penn State Worry Questionnaire. Behaviour Research and Therapy. 1990, 28: 487-495. 10.1016/0005-7967(90)90135-6.CrossRef
37.
go back to reference Schmidt S, Mühlan H, Power M: The EUROHIS-QOL 8-item index: Psychometric results of a cross-cultural field study. European Journal of Public Health. 2005, 16: 420-428. 10.1093/eurpub/cki155.CrossRefPubMed Schmidt S, Mühlan H, Power M: The EUROHIS-QOL 8-item index: Psychometric results of a cross-cultural field study. European Journal of Public Health. 2005, 16: 420-428. 10.1093/eurpub/cki155.CrossRefPubMed
38.
go back to reference Kessler R, Frank G: The impact of psychiatric disorders on work loss days. Psychological Medicine. 1997, 27: 861-873. 10.1017/S0033291797004807.CrossRefPubMed Kessler R, Frank G: The impact of psychiatric disorders on work loss days. Psychological Medicine. 1997, 27: 861-873. 10.1017/S0033291797004807.CrossRefPubMed
39.
go back to reference Rosenberg M: Society and the adolescent self-image. Revised edn. 1989, Middletown, CT: Wesleyan University Press Rosenberg M: Society and the adolescent self-image. Revised edn. 1989, Middletown, CT: Wesleyan University Press
40.
go back to reference Sherbourne CD, Stewart AL: The MOS Social Support Survey. Social Science Medicine. 1991, 32: 705-714. 10.1016/0277-9536(91)90150-B.CrossRefPubMed Sherbourne CD, Stewart AL: The MOS Social Support Survey. Social Science Medicine. 1991, 32: 705-714. 10.1016/0277-9536(91)90150-B.CrossRefPubMed
41.
go back to reference Russell DW: UCLA Loneliness Scale (Version 3): Reliability, Validity, and Factor Structure. Journal of Personality Assessment. 1996, 66: 20-40. 10.1207/s15327752jpa6601_2.CrossRefPubMed Russell DW: UCLA Loneliness Scale (Version 3): Reliability, Validity, and Factor Structure. Journal of Personality Assessment. 1996, 66: 20-40. 10.1207/s15327752jpa6601_2.CrossRefPubMed
43.
go back to reference Jorm AF, Korten AE, Jacomb PA, Christensen H, Rodgers B, Pollitt P: "Mental health literacy": A survey of the public's ability to recognise mental disorders and their beliefs about the effectiveness of treatment. Medical Journal of Australia. 1997, 166: 182-PubMed Jorm AF, Korten AE, Jacomb PA, Christensen H, Rodgers B, Pollitt P: "Mental health literacy": A survey of the public's ability to recognise mental disorders and their beliefs about the effectiveness of treatment. Medical Journal of Australia. 1997, 166: 182-PubMed
44.
go back to reference Rodgers ES, Chamberlin J, Ellison MLE, Crean T: A consumer-constructed scale to measure empowerment among users of mental health services. Psychiatric Services. 1997, 48: 1042-1047.CrossRef Rodgers ES, Chamberlin J, Ellison MLE, Crean T: A consumer-constructed scale to measure empowerment among users of mental health services. Psychiatric Services. 1997, 48: 1042-1047.CrossRef
45.
go back to reference Powell J, McCarthy N, Eysenbach G: Cross-sectional survey of users of Internet depression communities. BMC Psychiatry. 2003, 3: 19-10.1186/1471-244X-3-19.CrossRefPubMedPubMedCentral Powell J, McCarthy N, Eysenbach G: Cross-sectional survey of users of Internet depression communities. BMC Psychiatry. 2003, 3: 19-10.1186/1471-244X-3-19.CrossRefPubMedPubMedCentral
46.
go back to reference Seligman MEP: The effectiveness of psychotherapy: The Consumer Reports Study. American Psychologist. 1995, 50: 965-974. 10.1037/0003-066X.50.12.965.CrossRefPubMed Seligman MEP: The effectiveness of psychotherapy: The Consumer Reports Study. American Psychologist. 1995, 50: 965-974. 10.1037/0003-066X.50.12.965.CrossRefPubMed
47.
go back to reference Nielsen SL, Smart DW, Isakson RL, Worthen VE, Gregersen AT, Lambert MJ: The consumer reports effectiveness score: What did consumers report?. Journal of Counseling Psychology. 2004, 51: 25-37. 10.1037/0022-0167.51.1.25.CrossRef Nielsen SL, Smart DW, Isakson RL, Worthen VE, Gregersen AT, Lambert MJ: The consumer reports effectiveness score: What did consumers report?. Journal of Counseling Psychology. 2004, 51: 25-37. 10.1037/0022-0167.51.1.25.CrossRef
48.
go back to reference Gustafson DH, Hawkins R, Boberg E, Pingree S, Serline RE, Graziano F, Lung Chan C: Impact of a patient-centered, computer-based health information/support system. American Journal of Preventive Medicine. 1999, 16: 1-9. 10.1016/S0749-3797(98)00108-1.CrossRefPubMed Gustafson DH, Hawkins R, Boberg E, Pingree S, Serline RE, Graziano F, Lung Chan C: Impact of a patient-centered, computer-based health information/support system. American Journal of Preventive Medicine. 1999, 16: 1-9. 10.1016/S0749-3797(98)00108-1.CrossRefPubMed
49.
go back to reference Henry JD, Crawford JR: The short-form version of the Depression Anxiety Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical sample. British Journal of Clinical Psychology. 2005, 44: 227-239. 10.1348/014466505X29657.CrossRefPubMed Henry JD, Crawford JR: The short-form version of the Depression Anxiety Stress Scales (DASS-21): Construct validity and normative data in a large non-clinical sample. British Journal of Clinical Psychology. 2005, 44: 227-239. 10.1348/014466505X29657.CrossRefPubMed
50.
go back to reference Davidson JRT, Potts NLS, Richichi EA, Ford SM, Krishnan KRR, Smith RD, Wilson W: The brief social phobia scale. Journal of Clinical Psychiatry. 1991, 52: 48-51.PubMed Davidson JRT, Potts NLS, Richichi EA, Ford SM, Krishnan KRR, Smith RD, Wilson W: The brief social phobia scale. Journal of Clinical Psychiatry. 1991, 52: 48-51.PubMed
51.
go back to reference Spitzer RL, Kroenke K, Williams JBW: Patient Health Questionnaire Study Group. Validity and utility of a self-report version of PRIME-MD: The PHQ Primary Care Study. Journal of the American Medical Association. 1999, 282: 1737-1744. 10.1001/jama.282.18.1737.CrossRefPubMed Spitzer RL, Kroenke K, Williams JBW: Patient Health Questionnaire Study Group. Validity and utility of a self-report version of PRIME-MD: The PHQ Primary Care Study. Journal of the American Medical Association. 1999, 282: 1737-1744. 10.1001/jama.282.18.1737.CrossRefPubMed
52.
go back to reference Verbeke G, Molenberghs G: Linear mixed models for longitudinal data. 2000, New York: Springer-Verlag Verbeke G, Molenberghs G: Linear mixed models for longitudinal data. 2000, New York: Springer-Verlag
Metadata
Title
The ANU WellBeing study: a protocol for a quasi-factorial randomised controlled trial of the effectiveness of an Internet support group and an automated Internet intervention for depression
Authors
Kathleen M Griffiths
Dimity Crisp
Helen Christensen
Andrew J Mackinnon
Kylie Bennett
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2010
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-10-20

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