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BMC Cancer
Published in: BMC Cancer 1/2009

Open Access 01-12-2009 | Research article

Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma

Authors: Zhihua Yin, Baosen Zhou, Qincheng He, Mingchuan Li, Peng Guan, Xuelian Li, Zeshi Cui, Xiaoxia Xue, Meng Su, Rui Ma, Weijun Bai, Shuyue Xia, Yanduo Jiang, Shun Xu, Yi Lv, Xun Li

Published in: BMC Cancer | Issue 1/2009

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Abstract

Background

Excision repair cross-complementing group 1 (ERCC1) and group 2 (ERCC2), and X-ray repair cross-complementing group 1 (XRCC1) proteins play important roles in the repair of DNA damage and adducts. Single nucleotide polymorphisms (SNPs) of DNA repair genes are suspected to influence treatment effect and survival of cancer patients. This study aimed to investigate the relationship between polymorphisms in ERCC2, ERCC1 and XRCC1 genes and survival of non-smoking female patients with lung adenocarcinoma.

Methods

We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method to evaluate SNPs in ERCC2, ERCC1 and XRCC1 genes among 257 patients.

Results

The overall median survival time (MST) was 13.07 months. Increasing numbers of either ERCC1 118 or XRCC1 399 variant alleles were associated with shorter survival of non-smoking female lung adenocarcinoma patients (Log-rank P < 0.001). The adjusted hazard ratios (HRs) for individuals with CT or TT genotype at ERCC1 Asn118Asn were 1.48 and 2.67 compared with those with CC genotype. For polymorphism of XRCC1 399, the HRs were 1.28 and 2.68 for GA and AA genotype. When variant alleles across both polymorphisms were combined to analysis, the increasing number of variant alleles was associated with decreasing overall survival. Using the stepwise Cox regression analysis, we found that the polymorphisms in ERCC1 and XRCC1, tumor stage and chemotherapy or radiotherapy status independently predicted overall survival of non-smoking female patients with lung adenocarcinoma.

Conclusions

Genetic polymorphisms in ERCC1 and XRCC1 genes might be prognostic factors in non-smoking female patients with lung adenocarcinoma.
Appendix
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Metadata
Title
Association between polymorphisms in DNA repair genes and survival of non-smoking female patients with lung adenocarcinoma
Authors
Zhihua Yin
Baosen Zhou
Qincheng He
Mingchuan Li
Peng Guan
Xuelian Li
Zeshi Cui
Xiaoxia Xue
Meng Su
Rui Ma
Weijun Bai
Shuyue Xia
Yanduo Jiang
Shun Xu
Yi Lv
Xun Li
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2009
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-9-439

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