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BMC Cancer
Published in: BMC Cancer 1/2008

Open Access 01-12-2008 | Research article

Characterization of three new serous epithelial ovarian cancer cell lines

Authors: Véronique Ouellet, Magdalena Zietarska, Lise Portelance, Julie Lafontaine, Jason Madore, Marie-Line Puiffe, Suzanna L Arcand, Zhen Shen, Josée Hébert, Patricia N Tonin, Diane M Provencher, Anne-Marie Mes-Masson

Published in: BMC Cancer | Issue 1/2008

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Abstract

Background

Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G), as well as the matched ascites for one case (OV-1946).

Methods

In addition to growth parameters, the cell lines were characterized for anchorage independent growth, migration and invasion potential, ability to form spheroids and xenografts in SCID mice.

Results

While all cell lines were capable of anchorage independent growth, only the TOV-1946 and OV-1946 cell lines were able to form spheroid and produce tumors. Profiling of keratins, p53 and Her2 protein expression was assessed by immunohistochemistry and western blot analyses. Somatic TP53 mutations were found in all cell lines, with TOV-1946 and OV-1946 harboring the same mutation, and none harbored the commonly observed somatic mutations in BRAF, KRAS or germline BRCA1/2 mutations found to recur in the French Canadian population. Conventional cytogenetics and spectral karyotype (SKY) analyses revealed complex karyotypes often observed in ovarian disease.

Conclusion

This is the first report of the establishment of matched EOC cell lines derived from both solid tumor and ascites of the same patient.
Appendix
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Literature
1.
Colombo N, Van Gorp T, Parma G, Amant F, Gatta G, Sessa C, Vergote I: Ovarian cancer. Crit Rev Oncol Hematol. 2006, 60: 159-179. 10.1016/j.critrevonc.2006.03.004.CrossRefPubMed
2.
Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC: Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev. 2001, 22: 255-288. 10.1210/er.22.2.255.PubMed
3.
Heintz AP, Odicino F, Maisonneuve P, Beller U, Benedet JL, Creasman WT, Ngan HY, Pecorelli S: Carcinoma of the ovary. Int J Gynaecol Obstet. 2003, 83 Suppl 1: 135-166. 10.1016/S0020-7292(03)90118-4.CrossRefPubMed
4.
Provencher DM, Lounis H, Champoux L, Tetrault M, Manderson EN, Wang JC, Eydoux P, Savoie R, Tonin PN, Mes-Masson AM: Characterization of four novel epithelial ovarian cancer cell lines. In Vitro Cell Dev Biol Anim. 2000, 36: 357-361. 10.1290/1071-2690(2000)036<0357:COFNEO>2.0.CO;2.CrossRefPubMed
5.
DiSaia PJ, Morrow M, Kanabus J, Piechal W, Townsend DE: Two new tissue culture lines from ovarian cancer. Gynecol Oncol. 1975, 3: 215-219. 10.1016/S0090-8258(75)80006-0.CrossRefPubMed
6.
Fogh J, Trempe G: New human tumor cell lines. Human tumor cell lines in vitro. Edited by: Fogh J. 1975, New York, Plenum PressCrossRef
7.
Sinna GA, Beckman G, Lundgren E, Nordenson I, Roos G: Characterization of two human ovarian carcinoma cell lines. Gynecol Oncol. 1979, 7: 267-280. 10.1016/0090-8258(79)90104-5.CrossRefPubMed
8.
Bast RC, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC: Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest. 1981, 68: 1331-1337. 10.1172/JCI110380.CrossRefPubMedPubMedCentral
9.
Hamilton TC, Young RC, McKoy WM, Grotzinger KR, Green JA, Chu EW, Whang-Peng J, Rogan AM, Green WR, Ozols RF: Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors. Cancer Res. 1983, 43: 5379-5389.PubMed
10.
Buick RN, Pullano R, Trent JM: Comparative properties of five human ovarian adenocarcinoma cell lines. Cancer Res. 1985, 45: 3668-3676.PubMed
11.
Hill BT, Whelan RD, Gibby EM, Sheer D, Hosking LK, Shellard SA, Rupniak HT: Establishment and characterisation of three new human ovarian carcinoma cell lines and initial evaluation of their potential in experimental chemotherapy studies. Int J Cancer. 1987, 39: 219-225. 10.1002/ijc.2910390216.CrossRefPubMed
12.
Langdon SP, Lawrie SS, Hay FG, Hawkes MM, McDonald A, Hayward IP, Schol DJ, Hilgers J, Leonard RC, Smyth JF: Characterization and properties of nine human ovarian adenocarcinoma cell lines. Cancer Res. 1988, 48: 6166-6172.PubMed
13.
Briers TW, Stroobants P, Vandeputte TM, Nouwen EJ, Conraads MV, Eestermans G, Van Bockstaele D, De Broe ME: Establishment and characterization of a human ovarian neoplastic cell line, DO-s. Cancer Res. 1989, 49: 5153-5161.PubMed
14.
Golombick T, Dansey R, Bezwoda WR, Rosendorff J: Establishment and characterization of two new human ovarian cancer cell lines UWOV1 and UWOV2 and a subline UWOV2 (Sf) growing in serum-free conditions: growth characteristics, biochemical, and cytogenetic studies. In Vitro Cell Dev Biol. 1990, 26: 447-454. 10.1007/BF02624086.CrossRefPubMed
15.
Wong WS, Wong YF, Ng YT, Huang PD, Chew EC, Ho TH, Chang MZ: Establishment and characterization of a new human cell line derived from ovarian clear cell carcinoma. Gynecol Oncol. 1990, 38: 37-45. 10.1016/0090-8258(90)90008-9.CrossRefPubMed
16.
Golombick T, Bezwoda WR: In vitro maintenance of a new ovarian cancer cell line in protein-free media: a potential model for autonomous growth and tumor progression. Eur J Cell Biol. 1991, 56: 459-463.PubMed
17.
Yamada T, Ueda M, Otsuki Y, Ueki M, Sugimoto O: Establishment and characterization of a cell line (OMC-3) originating from a human mucinous cystadenocarcinoma of the ovary. Gynecol Oncol. 1991, 40: 118-128. 10.1016/0090-8258(91)90102-B.CrossRefPubMed
18.
Mobus V, Gerharz CD, Press U, Moll R, Beck T, Mellin W, Pollow K, Knapstein PG, Kreienberg R: Morphological, immunohistochemical and biochemical characterization of 6 newly established human ovarian carcinoma cell lines. Int J Cancer. 1992, 52: 76-84. 10.1002/ijc.2910520115.CrossRefPubMed
19.
Grunt TW, Oeller H, Somay C, Dittrich C: Different propensity for spontaneous differentiation of cell clones isolated from the human ovarian surface epithelial cell line HOC-7. Differentiation. 1993, 53: 45-50. 10.1111/j.1432-0436.1993.tb00644.x.CrossRefPubMed
20.
Provencher DM, Finstad CL, Saigo PE, Rubin SC, Hoskins WJ, Federici MG, Stockert E, Lloyd KO, Lewis JL: Comparison of antigen expression on fresh and cultured ascites cells and on solid tumors of patients with epithelial ovarian cancer. Gynecol Oncol. 1993, 50: 78-83. 10.1006/gyno.1993.1167.CrossRefPubMed
21.
Hirte HW, Kaiser JS, Bacchetti S: Establishment and characterization of four human epithelial ovarian carcinoma cell lines. Cancer. 1994, 74: 900-906. 10.1002/1097-0142(19940801)74:3<900::AID-CNCR2820740317>3.0.CO;2-N.CrossRefPubMed
22.
Buller RE, Niemann T, Connor JP, Squatrito RC, Skilling JS, Anderson B: Isolation and preliminary characterization of an ovarian carcinoma cell line from a patient with familial ovarian cancer. Gynecol Oncol. 1995, 56: 39-44. 10.1006/gyno.1995.1007.CrossRefPubMed
23.
Alama A, Barbieri F, Favre A, Cagnoli M, Noviello E, Pedulla F, Viale M, Foglia G, Ragni N: Establishment and characterization of three new cell lines derived from the ascites of human ovarian carcinomas. Gynecol Oncol. 1996, 62: 82-88. 10.1006/gyno.1996.0194.CrossRefPubMed
24.
Kim JW, Lee CG, Lyu MS, Kim HK, Rha JG, Kim DH, Kim SJ, Namkoong SE: A new cell line from human undifferentiated carcinoma of the ovary: establishment and characterization. J Cancer Res Clin Oncol. 1997, 123: 82-90. 10.1007/BF01269885.CrossRefPubMed
25.
Mancini A, Borrelli A, Formisano S, Masucci MT, Maffeo A, Perla G, De Martino L, Bevilacqua N, Botti G, Maggino T: Establishment and growth regulation of a novel ovarian cancer cell line from a poorly-differentiated adenocarcinoma: proposal for a new treatment. Eur J Gynaecol Oncol. 1999, 20: 45-52.PubMed
26.
Bar JK, Harlozinska A: Morphological and phenotypic characterization of a new established ovarian carcinoma cell line (OvBH-1). Anticancer Res. 2000, 20: 2975-2980.PubMed
27.
Sato S, Kobayashi Y, Okuma Y, Kondo H, Kanishi Y, Saito K, Kiguchi K: Establishment and characterization of a cell-line originated from human mucinous cystadenocarcinoma of the ovary. Hum Cell. 2002, 15: 171-177.CrossRefPubMed
28.
Saga Y, Suzuki M, Machida S, Ohwada M, Sato I: Establishment of a new cell line (TAYA) of clear cell adenocarcinoma of the ovary and its radiosensitivity. Oncology. 2002, 62: 180-184. 10.1159/000048265.CrossRefPubMed
29.
Nishikawa Y, Yoshida Y, Kawahara K, Kurokawa T, Tajima K, Kotsuji F: Establishment of a novel human ovarian cancer cell line with high anchorage-independent growth ability. Int J Oncol. 2003, 23: 1679-1686.PubMed
30.
Woods LK, Morgan RT, Quinn LA, Moore GE, Semple TU, Stedman KE: Comparison of four new cell lines from patients with adenocarcinoma of the ovary. Cancer Res. 1979, 39: 4449-4459.PubMed
31.
Crickard K, Niedbala MJ, Crickard U, Yoonessi M, Sandberg AA, Okuyama K, Bernacki RJ, Satchidanand SK: Characterization of human ovarian and endometrial carcinoma cell lines established on extracellular matrix. Gynecol Oncol. 1989, 32: 163-173. 10.1016/S0090-8258(89)80028-9.CrossRefPubMed
32.
Imai S, Kiyozuka Y, Maeda H, Noda T, Hosick HL: Establishment and characterization of a human ovarian serous cystadenocarcinoma cell line that produces the tumor markers CA-125 and tissue polypeptide antigen. Oncology. 1990, 47: 177-184.CrossRefPubMed
33.
van den Berg-Bakker CA, Hagemeijer A, Franken-Postma EM, Smit VT, Kuppen PJ, van Ravenswaay Claasen HH, Cornelisse CJ, Schrier PI: Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics. Int J Cancer. 1993, 53: 613-620. 10.1002/ijc.2910530415.CrossRefPubMed
34.
Yonamine K, Hayashi K, Iida T: Establishment and characterization of human ovarian clear cell adenocarcinoma cell line (SMOV-2), and its cytotoxity by anticancer agents. Hum Cell. 1999, 12: 139-148.PubMed
35.
Emoto M, Oshima K, Ishiguro M, Iwasaki H, Kawarabayashi T, Kikuchi M: Establishment and characterization of a serous papillary adenocarcinoma cell line of the human ovary in a serum-free culture. Pathol Res Pract. 1999, 195: 237-242.CrossRefPubMed
36.
Aoki D, Suzuki N, Susumu N, Noda T, Suzuki A, Tamada Y, Higashiguchi A, Oie S, Nozawa S: Establishment and characterization of the RMG-V cell line from human ovarian clear cell adenocarcinoma. Hum Cell. 2005, 18: 143-146.CrossRefPubMed
37.
Scoles DR, Pavelka J, Cass I, Tran H, Baldwin RL, Armstrong K, Karlan BY: Characterization of CSOC 882, a novel immortalized ovarian cancer cell line expressing EGFR, HER2, and activated AKT. Gynecol Oncol. 2007, 104: 120-128. 10.1016/j.ygyno.2006.07.023.CrossRefPubMed
38.
Auersperg N, Maines-Bandiera SL, Dyck HG, Kruk PA: Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes. Lab Invest. 1994, 71: 510-518.PubMed
39.
Nitta M, Katabuchi H, Ohtake H, Tashiro H, Yamaizumi M, Okamura H: Characterization and tumorigenicity of human ovarian surface epithelial cells immortalized by SV40 large T antigen. Gynecol Oncol. 2001, 81: 10-17. 10.1006/gyno.2000.6084.CrossRefPubMed
40.
Shenhua X, Lijuan Q, Hanzhou N, Xinghao N, Chihong Z, Gu Z, Weifang D, Yongliang G: Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization. J Exp Clin Cancer Res. 1999, 18: 233-239.PubMed
41.
Yabushita H, Ueno N, Sawaguchi K, Higuchi K, Noguchi M, Ishihara M: Establishment and characterization of a new human cell-line (AMOC-2) derived from a serous adenocarcinoma of ovary. Nippon Sanka Fujinka Gakkai Zasshi. 1989, 41: 888-894.PubMed
42.
Kruk PA, Maines-Bandiera SL, Auersperg N: A simplified method to culture human ovarian surface epithelium. Lab Invest. 1990, 63: 132-136.PubMed
43.
Lounis H, Provencher D, Godbout C, Fink D, Milot MJ, Mes-Masson AM: Primary cultures of normal and tumoral human ovarian epithelium: a powerful tool for basic molecular studies. Exp Cell Res. 1994, 215: 303-309. 10.1006/excr.1994.1346.CrossRefPubMed
44.
Keller GM: In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol. 1995, 7: 862-869. 10.1016/0955-0674(95)80071-9.CrossRefPubMed
45.
Zietarska M, Maugard CM, Filali-Mouhim A, Alam-Fahmy M, Tonin PN, Provencher D, Mes-Masson AM: Molecular description of a 3-D in vitro model for the study of epithelial ovarian cancer. Mol Carcinog. 2007, In Press:
46.
Bossolasco M, Veillette F, Bertrand R, Mes-Masson AM: Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. Oncogene. 2006, 25: 4549-4558. 10.1038/sj.onc.1209488.CrossRefPubMed
47.
Shigeta M, Sanzen N, Ozawa M, Gu J, Hasegawa H, Sekiguchi K: CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization. J Cell Biol. 2003, 163: 165-176. 10.1083/jcb.200301075.CrossRefPubMedPubMedCentral
48.
Ronot X, Doisy A, Tracqui P: Quantitative study of dynamic behavior of cell monolayers during in vitro wound healing by optical flow analysis. Cytometry. 2000, 41: 19-30. 10.1002/1097-0320(20000901)41:1<19::AID-CYTO3>3.0.CO;2-X.CrossRefPubMed
49.
Arcand SL, Provencher D, Mes-Masson AM, Tonin PN: OGG1 Cys326 variant, allelic imbalance of chromosome band 3p25.3 and TP53 mutations in ovarian cancer. Int J Oncol. 2005, 27: 1315-1320.PubMed
50.
Arcand SL, Maugard CM, Ghadirian P, Robidoux A, Perret C, Zhang P, Fafard E, Mes-Masson AM, Foulkes WD, Provencher D, Narod SA, Tonin PN: Germline TP53 mutations in BRCA1 and BRCA2 mutation-negative French Canadian breast cancer families. Breast Cancer Res Treat. 2007
51.
Samouelian V, Maugard CM, Jolicoeur M, Bertrand R, Arcand SL, Tonin PN, Provencher DM, Mes-Masson AM: Chemosensitivity and radiosensitivity profiles of four new human epithelial ovarian cancer cell lines exhibiting genetic alterations in BRCA2, TGFbeta-RII, KRAS2, TP53 and/or CDNK2A. Cancer Chemother Pharmacol. 2004, 54: 497-504. 10.1007/s00280-004-0843-9.CrossRefPubMed
52.
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA: Mutations of the BRAF gene in human cancer. Nature. 2002, 417: 949-954. 10.1038/nature00766.CrossRefPubMed
53.
Oros KK, Ghadirian P, Greenwood CM, Perret C, Shen Z, Paredes Y, Arcand SL, Mes-Masson AM, Narod SA, Foulkes WD, Provencher D, Tonin PN: Significant proportion of breast and/or ovarian cancer families of French Canadian descent harbor 1 of 5 BRCA1 and BRCA2 mutations. Int J Cancer. 2004, 112: 411-419. 10.1002/ijc.20406.CrossRefPubMed
54.
Tonin PN, Mes-Masson AM, Futreal PA, Morgan K, Mahon M, Foulkes WD, Cole DE, Provencher D, Ghadirian P, Narod SA: Founder BRCA1 and BRCA2 mutations in French Canadian breast and ovarian cancer families. Am J Hum Genet. 1998, 63: 1341-1351. 10.1086/302099.CrossRefPubMedPubMedCentral
55.
Shaffer LG, Tommerup N: ISCN, An International System for Human Cytogenetic Nomenclature. 2005, Basel, S. Karger AG
56.
57.
Petitjean A, Mathe E, Kato S, Ishioka C, Tavtigian SV, Hainaut P, Olivier M: Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat. 2007, 28: 622-629. 10.1002/humu.20495.CrossRefPubMed
58.
59.
Puiffe ML, Le Page C, Filali-Mouhim A, Zietarska M, Ouellet V, Tonin PN, Chevrette M, Provencher DM, Mes-Masson AM: Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer. Neoplasia. 2007, 9: 820-829. 10.1593/neo.07472.CrossRefPubMedPubMedCentral
60.
Prat J: Ovarian carcinomas, including secondary tumors: diagnostically challenging areas. Mod Pathol. 2005, 18 Suppl 2: S99-111. 10.1038/modpathol.3800312.CrossRefPubMed
61.
Boente MP, Hurteau J, Rodriguez GC, Bast RC, Berchuck A: The biology of ovarian cancer. Curr Opin Oncol. 1993, 5: 900-907. 10.1097/00001622-199309000-00020.CrossRefPubMed
62.
Berchuck A, Elbendary A, Havrilesky L, Rodriguez GC, Bast RC: Pathogenesis of ovarian cancers. J Soc Gynecol Investig. 1994, 1: 181-190. 10.1159/000097159.PubMed
63.
Aunoble B, Sanches R, Didier E, Bignon YJ: Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review). Int J Oncol. 2000, 16: 567-576.PubMed
64.
Meden H, Kuhn W: Overexpression of the oncogene c-erbB-2 (HER2/neu) in ovarian cancer: a new prognostic factor. [Review] [36 refs]. Eur J Obstet Gynecol Rep Biol. 1997, 71: 173-179. 10.1016/S0301-2115(96)02630-9.CrossRef
65.
Meden H, Marx D, Schauer A, Wuttke W, Kuhn W: Prognostic significance of p105 (c-erbB-2 HER2/neu) serum levels in patients with ovarian cancer. Anticancer Res. 1997, 17: 757-760.PubMed
66.
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987, 235: 177-182. 10.1126/science.3798106.CrossRefPubMed
67.
Calvo BF, Levine AM, Marcos M, Collins QF, Iacocca MV, Caskey LS, Gregory CW, Lin Y, Whang YE, Earp HS, Mohler JL: Human epidermal receptor-2 expression in prostate cancer. Clin Cancer Res. 2003, 9: 1087-1097.PubMed
68.
Burleson KM, Boente MP, Pambuccian SE, Skubitz AP: Disaggregation and invasion of ovarian carcinoma ascites spheroids. J Transl Med. 2006, 4: 6-10.1186/1479-5876-4-6.CrossRefPubMedPubMedCentral
69.
Freedman VH, Shin SI: Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium. Cell. 1974, 3: 355-359. 10.1016/0092-8674(74)90050-6.CrossRefPubMed
70.
Cody NA, Ouellet V, Manderson EN, Quinn MC, Filali-Mouhim A, Tellis P, Zietarska M, Provencher DM, Mes-Masson AM, Chevrette M, Tonin PN: Transfer of chromosome 3 fragments suppresses tumorigenicity of an ovarian cancer cell line monoallelic for chromosome 3p. Oncogene. 2007, 26: 618-632. 10.1038/sj.onc.1209821.CrossRefPubMed
71.
Taetle R, Aickin M, Yang JM, Panda L, Emerson J, Roe D, Adair L, Thompson F, Liu Y, Wisner L, Davis JR, Trent J, Alberts DS: Chromosome abnormalities in ovarian adenocarcinoma: I. Nonrandom chromosome abnormalities from 244 cases. Genes Chromosomes Cancer. 1999, 25: 290-300. 10.1002/(SICI)1098-2264(199907)25:3<290::AID-GCC12>3.0.CO;2-G.CrossRefPubMed
72.
Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, Yu J, Wang L, Montie JE, Rubin MA, Pienta KJ, Roulston D, Shah RB, Varambally S, Mehra R, Chinnaiyan AM: Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature. 2007, 448: 595-599. 10.1038/nature06024.CrossRefPubMed
73.
Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005, 310: 644-648. 10.1126/science.1117679.CrossRefPubMed
74.
Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA: Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res. 2007, 67: 10736-10743. 10.1158/0008-5472.CAN-07-2742.CrossRefPubMed
75.
Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M: Characterizing the cancer genome in lung adenocarcinoma. Nature. 2007
Metadata
Title
Characterization of three new serous epithelial ovarian cancer cell lines
Authors
Véronique Ouellet
Magdalena Zietarska
Lise Portelance
Julie Lafontaine
Jason Madore
Marie-Line Puiffe
Suzanna L Arcand
Zhen Shen
Josée Hébert
Patricia N Tonin
Diane M Provencher
Anne-Marie Mes-Masson
Publication date
01-12-2008
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2008
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-8-152

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