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Open Access 01-12-2006 | Research article

Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity

Authors: Thomas Fillies, Richard Werkmeister, Jens Packeisen, Burkhard Brandt, Philippe Morin, Dieter Weingart, Ulrich Joos, Horst Buerger

Published in: BMC Cancer | Issue 1/2006

Abstract

Background

Intermediary filaments are involved in cell motility and cancer progression. In a variety of organs, the expression of distinct intermediary filaments are associated with patient prognosis. In this study, we seeked to define the prognostic potential of cytokeratin and vimentin expression patterns in squamous cell carcinomas (SCC's) of the oral cavity.

Methods

308 patients with histologically proven and surgically treated squamous cell carcinomas of the oral cavity were investigated for the immunohistochemical expression of a variety of intermediary filaments including high- and low-molecular weight cytokeratins (Ck's), such as Ck 5/6, Ck 8/18, Ck 1, CK 10, Ck 14, Ck 19 and vimentin, using the tissue microarray technique. Correlations between clinical features and the expression of Cytokeratins and vimentin were evaluated statistically by Kaplan-Meier curves and multivariate Cox regression analysis.

Results

The expression of Ck 8/18 and Ck 19 were overall significantly correlated with a poor clinical prognosis (Ck 8/18 p = 0.04; Ck19 p < 0.01). These findings could also be reproduced for Ck 8/18 in primary nodal-negative SCC's and held true in multivariate-analysis. No significant correlation with patient prognosis could be found for the expression of the other cytokeratins and for vimentin.

Conclusion

The expression of Ck 8/18 in SCC's of the oral cavity is an independent prognostic marker and indicates a decreased overall and progression free survival. These results provide an extended knowledge about the role of intermediary filament expression patterns in SCC's.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/6/10/prepub

Title: Cytokeratin 8/18 expression indicates a poor prognosis in squamous cell carcinomas of the oral cavity
Authors: Thomas Fillies
Richard Werkmeister
Jens Packeisen
Burkhard Brandt
Philippe Morin
Dieter Weingart
Ulrich Joos
Horst Buerger
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2006
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-6-10

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Abstract

Background

Methods

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