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Open Access 01-12-2005 | Research article

Family history of colorectal cancer in Iran

Authors: Mahboobeh Mahdavinia, Faraz Bishehsari, Reza Ansari, Nasim Norouzbeigi, Ahmad Khaleghinejad, Mahshid Hormazdi, Naser Rakhshani, Reza Malekzadeh

Published in: BMC Cancer | Issue 1/2005

Abstract

Background

Previous reports show a high proportion of young CRC patients in Iran. In this study we aim to look for the clustering of colorectal cancer in families of a series of CRC patients from Iran.

Methods

The family history of cancer is traced in 449 CRC patients of which 112 were 45 yrs or younger and 337 were older than 45 yrs at time of diagnosis. The patients were admitted in two hospitals in Tehran, during a 4-year period.

Results

Clinical diagnosis of HNPCC was established in 21 (4.7%) probands. Family history of CRC was more frequently reported by early-onset than by late-onset patients (29.5% vs. 12.8%, p < 0.001).

Distribution of tumor site differed significantly between those with and without family history of CRC. Right colon cancer was the most frequent site (23/45, 35.4%) observed in patients with positive family history of colorectal cancer.

Conclusion

The relatively high frequency of CRC clustering along with HNPCC in our patients should be further confirmed with larger sample size population-based and genetic studies to establish a cost effective molecular screening for the future.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/5/112/prepub

Title: Family history of colorectal cancer in Iran
Authors: Mahboobeh Mahdavinia
Faraz Bishehsari
Reza Ansari
Nasim Norouzbeigi
Ahmad Khaleghinejad
Mahshid Hormazdi
Naser Rakhshani
Reza Malekzadeh
Publication date: 01-12-2005
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2005
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-5-112

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