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BMC Cancer

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Open Access 01-12-2003 | Research article

Tamoxifen stimulates arachidonic acid release from rat liver cells by an estrogen receptor-independent, non-genomic mechanism

Author: Lawrence Levine

Published in: BMC Cancer | Issue 1/2003

Abstract

Background

Tamoxifen is widely prescribed for the treatment of breast cancer. Its success has been attributed to the modulation of the estrogen receptor. I have previously proposed that the release of arachidonic acid from cells may also mediate cancer prevention.

Methods

Rat liver cells were radiolabelled with arachidonic acid. The release of [³H] arachidonic acid after various times of incubation of the cells with tamoxifen was measured.

Results

Tamoxifen, at micromolar concentrations, stimulates arachidonic acid release. The stimulation is rapid and is not affected by pre-incubation of the cells with actinomycin or the estrogen antagonist ICI-182,780.

Conclusions

The stimulation of AA release by tamoxifen is not mediated by estrogen receptor occupancy and is non-genomic.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/3/24/prepub

Title: Tamoxifen stimulates arachidonic acid release from rat liver cells by an estrogen receptor-independent, non-genomic mechanism
Author: Lawrence Levine
Publication date: 01-12-2003
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2003
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-3-24

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Abstract

Background

Methods

Results

Conclusions

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