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BMC Cancer

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Open Access 01-12-2011 | Research article

Overexpression of members of the microRNA-183 family is a risk factor for lung cancer: A case control study

Authors: Wangyu Zhu, XiaoGuang Liu, JianYing He, DongDong Chen, YanYan Hunag, Yong Kui Zhang

Published in: BMC Cancer | Issue 1/2011

Abstract

Background

Lung cancer is the leading cause of cancer-related deaths worldwide. Early detection is considered critical for lung cancer treatment. MicroRNAs (miRNAs) have shown promise as diagnostic and prognostic indicators. This study was to identify specific miRNAs with diagnostic and prognostic value for patients with lung cancer, and to explore the correlation between expression profiles of miRNAs and patient survival.

Methods

Gene expression of members of the miR-183 family (miR-96, miR-182, and miR-183) were examined in 70 paired samples from lung cancer patients (primary cancer and non-cancerous tissues and sera), as well as 44 serum samples from normal volunteers and lung cancer cell lines by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR). The correlation between the expression of miRNAs in tissues, sera, and patient overall survival were also examined by log-rank and Cox regression analysis.

Results

Expression levels of members of the miR-183 family in lung cancer tumor and sera were higher than that of their normal counterparts. The miR-96 expression in tumors was positively associated with its expression in sera. Log-rank and Cox regression analyses demonstrated that high expression of tumor and serum miRNAs of the miR-183 family were associated with overall poor survival in patients with lung cancer.

Conclusions

Our results suggest that the expressions of miR-96, miR-182, and miR-183 in tumor and sera may be considered potential novel biomarkers for the diagnosis and prognosis of lung cancer.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/11/393/prepub

Title: Overexpression of members of the microRNA-183 family is a risk factor for lung cancer: A case control study
Authors: Wangyu Zhu
XiaoGuang Liu
JianYing He
DongDong Chen
YanYan Hunag
Yong Kui Zhang
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2011
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-11-393

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