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BMC Cancer
Published in: BMC Cancer 1/2011

Open Access 01-12-2011 | Research article

Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8

Authors: Giovanna E Carpagnano, Grazia P Palladino, Donato Lacedonia, Anna Koutelou, Silvio Orlando, Maria P Foschino-Barbaro

Published in: BMC Cancer | Issue 1/2011

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Abstract

Background

Recent advances in lung cancer biology presuppose its inflammatory origin. In this regard, LTB-4 and IL-8 are recognized to play a crucial role in neutrophil recruitment into airways during lung cancer.
Notwithstanding the intriguing hypothesis, the exact role of neutrophilic inflammation in tumour biology remains complex and not completely known.
The aim of this study was to give our contribution in this field by investigating LTB-4 and IL-8 in the breath condensate of NSCLC patients and verifying their role in cancer development and progression.

Method

We enrolled 50 NSCLC patients and 35 controls. LTB-4 and IL-8 concentrations were measured in the breath condensate and the blood of all the subjects under study using EIA kits. Thirty NSCLC patients and ten controls underwent induced sputum collection and analysis.

Results

LTB-4 and IL-8 resulted higher in breath condensate and the blood of NSCLC patients compared to controls. Significantly higher concentrations were found as the cancer stages progressed. A positive correlation was observed between exhaled IL-8 and LTB-4 and the percentage of neutrophils in the induced sputum.

Conclusion

The high concentrations of exhaled LTB-4 and IL-8 showed the presence of a neutrophilic inflammation in the airways of NSCLC patients and gave a further support to the inflammatory signalling in lung cancer. These exhaled proteins could represent a suitable non-invasive marker in the diagnosis and monitoring of lung cancer.
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Metadata
Title
Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8
Authors
Giovanna E Carpagnano
Grazia P Palladino
Donato Lacedonia
Anna Koutelou
Silvio Orlando
Maria P Foschino-Barbaro
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2011
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-11-226

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